Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence [PDF]
Int J Mol Sci, 2020 Cerebral edema and contusion expansion are major determinants of morbidity and mortality after TBI. Current treatment options are reactive, suboptimal and associated with significant side effects.
R. Jha +9 more
semanticscholar +3 more sources
Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury [PDF]
Crit Care Med, 2017 Objectives: Cerebral edema is a key poor prognosticator in traumatic brain injury. There are no biomarkers identifying patients at-risk, or guiding mechanistically-precise therapies.
R. Jha +11 more
semanticscholar +3 more sources
Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion [PDF]
J Neurotrauma, 2019 In severe traumatic brain injury (TBI), contusions often are worsened by contusion expansion or hemorrhagic progression of contusion (HPC), which may double the original contusion volume and worsen outcome.
V. Gerzanich +10 more
semanticscholar +3 more sources
Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat [PDF]
Br J Pharmacol, 2018 Sulfonylureas (SUs) have been suggested to have an insulin‐independent blood glucose‐decreasing activity due to an extrapancreatic effect. However, a lack of adequate in vivo evidence makes this statement controversial. Here, we aimed to evaluate whether
Xiao-jun Zhou +7 more
semanticscholar +2 more sources
Myocardial protection by adenosine triphosphate−sensitive potassium channel opener diazoxide involves sulfonylurea receptor 2 subunitCentral MessagePerspective [PDF]
JTCVS OpenObjective: Pharmacologic openers of adenosine triphosphate-sensitive potassium (KATP) channels mimic ischemic preconditioning and are cardioprotective.
Jie Wang, MD +6 more
doaj +2 more sources
ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate KATP channels [PDF]
J Biol Chem, 2018 Neuroendocrine-type ATP-sensitive K+ (KATP) channels are metabolite sensors coupling membrane potential with metabolism, thereby linking insulin secretion to plasma glucose levels.
J. Sikimić +7 more
semanticscholar +2 more sources
Archives of Medical Research, 2009 Background ----- The sulfonylureas are hypoglycemic agents used for promotion of insulin secretion in type 2 diabetics. They bind to sulfonylurea receptor-1 (SUR-1), which is a functional subunit of the ATP-sensitive potassium channel (KATP).
Nora Nikolac Gabaj, Ana-Maria Simundic
exaly +3 more sources
Serum Sulfonylurea Receptor-1 Levels After Acute Supratentorial Intracerebral Hemorrhage: Implication for Prognosis [PDF]
Neuropsychiatric Disease and Treatment, 2022 Cheng-Jun Zhuge,1 Cheng-Peng Zhan,2 Ke-Wei Wang,1 Xin-Jiang Yan,2 Guo-Feng Yu2 1The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Department of Neurosurgery, The Quzhou Affiliated Hospital
Zhuge CJ +4 more
doaj +2 more sources
aThe characteristics of glucose metabolism in the sulfonylurea receptor 1 knockout rat model [PDF]
Molecular Medicine, 2019 Background Sulfonylurea receptor 1 (SUR1) is primarily responsible for glucose regulation in normal conditions. Here, we sought to investigate the glucose metabolism characteristics of SUR1 −/− rats.
Xiaojun Zhou +7 more
doaj +2 more sources
Endocrinology, Diabetes & Metabolism Case Reports, 2018 We report a case of a woman with diabetes mellitus caused by a genetic defect in ABCC8-coding sulfonylurea receptor 1 (SUR1), a subunit of the ATP-sensitive potassium (KATP) channel protein. She was diagnosed with diabetes at 7 days after birth.
Akihiko Ando +2 more
doaj +2 more sources