Results 1 to 10 of about 13,734 (118)

Efficacy and safety of glibenclamide therapy after intracerebral haemorrhage (GATE-ICH): A multicentre, prospective, randomised, controlled, open-label, blinded-endpoint, phase 2 clinical trial

EClinicalMedicine, 2022
Summary: Background: Glibenclamide is a promising agent for treating brain oedema, but whether it improves clinical outcomes in patients with intracerebral haemorrhage (ICH) remains unclear.
Jian Qian
exaly   +3 more sources

A sensitive bioanalytical method for the simultaneous determination of amlodipine and glibenclamide [PDF]

Pharmaceutical Sciences Asia, 2022
Type 2 diabetes mellitus triggers hypertension as a complication. The use of amlodipine and glibenclamide drugs simultaneously results in a synergistic and effective lowering of blood sugar and blood pressure.
Febrina Amelia Saputri, Febrina Amelia Saputri, Aliya Nur Hasanah, Mutakin, Taofik Rusdiana, Ingrid Suryanti Surono, Rizky Abdulah, Rizky Abdulah   +7 more
doaj   +1 more source

Glibenclamide decreases ATP-induced intracellular calcium transient elevation via inhibiting reactive oxygen species and mitochondrial activity in macrophages. [PDF]

PLoS ONE, 2014
Increasing evidence has revealed that glibenclamide has a wide range of anti-inflammatory effects. However, it is unclear whether glibenclamide can affect the resting and adenosine triphosphate (ATP)-induced intracellular calcium ([Ca(2+)]i) handling in ...
Duo-ling Li, Zhi-yong Ma, Zhi-jie Fu, Ming-ying Ling, Chuan-zhu Yan, Yun Zhang   +5 more
doaj   +1 more source

The effects of glibenclamide on thyroid function tests in type 2 diabetic patients [PDF]

المجلة العراقية للصيدلة, 2013
Objective: to determine the long-term effect of glibenclamide on thyroid function tests in type 2 diabetic patients. Materials and methods: A total of 63 diabetic ...
Marwan M. Merkhan
doaj   +1 more source

Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients [PDF]

Pharmacia, 2021
Metformin and glibenclamide may have beneficial effects on the levels of trace elements in diabetic patients. The aim of the current study was to assess the effects of metformin and glibenclamide on the concentrations of copper (Cu), zinc (Zn) and ...
Jehan A. Mohammad, Ammar A. Y. Almulathanon, Fatimah Haitham Fathi   +2 more
doaj   +3 more sources

Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats.

PLoS ONE, 2021
Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH.
Tiffany F C Kung, Cassandra M Wilkinson, Christine A Dirks, Glen C Jickling, Frederick Colbourne   +4 more
doaj   +1 more source

PENGARUH PEMBERIAN EKSTRAK DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP GLIBENKLAMID DALAM MENURUNKAN KADAR GLUKOSA DARAH MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2016
The use of herbal medicines and synthetic drugs simultaneously carried out by diabetics for the maintenance of blood glucose levels, such as the use of glibenclamide and bay leaf.
Nur Hikmah, Yuliet Yuliet, Khildah Khaerati   +2 more
doaj   +1 more source

Formulation and Characterization of Glibenclamide Solid Lipid Submicroparticles Formated by Virgin Coconut Oil and Solid Matrix Surfactant

Science and Technology Indonesia, 2021
Glibenclamide has the biopharmaceutics classification system (BCS) class II which has high permeability and low solubility. The solubility of glibenclamide can be enhanced by forming solid lipid nanoparticles (SLN).
Mardiyanto Mardiyanto, Najma Annuria Fithri, Annisa Amriani, Herlina Herlina, Dwi Purnama Sari   +4 more
doaj   +1 more source

Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents.

PLoS ONE, 2015
Activating mutations in the Kir6.2 (KCNJ11) subunit of the ATP-sensitive potassium channel cause neonatal diabetes (ND). Patients with severe mutations also suffer from neurological complications.
Carolina Lahmann, Holger B Kramer, Frances M Ashcroft   +2 more
doaj   +1 more source

Comparative study between Metformin, Glibenclamide and their combination in newly diagnosed diabetic (type II) patients in Hawler City

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2012
Type 2 diabetes mellitus is a complex progressive disorder characterized by impaired insulin sensitivity, reduced insulin secretion and progressive failure of pancreatic β – cells.
Sazan D. S., Kassim J.S., Ansam N.H.
doaj   +1 more source