Results 1 to 10 of about 19,031 (203)

CO2 utilization as a gas antisolvent in the production of glibenclamide nanoparticles, glibenclamide-HPMC, and glibenclamide-PVP composites

Journal of CO2 Utilization
Glibenclamide is an antidiabetic drug that also acts as an anti-inflammatory factor and reduces oxidative stress, medullary edema, and heart attack. Glibenclamide has high permeability and poor solubility in water (BCS class II).
Seyed Ali Sajadian, Nadia Esfandiari, Luis Padrela   +2 more
exaly   +4 more sources

Five‐year follow‐up of incretin‐based therapy in a patient with KCNJ11‐related permanent neonatal diabetes: Achieving insulin discontinuation and sulfonylurea reduction [PDF]

Journal of Diabetes Investigation, Volume 17, Issue 6, Page 1075-1078, June 2026.
In a woman with KCNJ11‐related permanent neonatal diabetes mellitus, incretin‐based therapy enabled insulin discontinuation and maintained glycemic control for more than 5 years, with HbA1c between 6.1% and 6.5% on the lowest semaglutide dose, dose‐dependent improvement in insulin secretion, and an approximately 60% reduction in glibenclamide dose ...
Toshiaki Ohkuma, Ryoichiro Aotani, Wakako Sakamoto, Ayaka Oshiro, Tetsuro Ago   +4 more
wiley   +2 more sources

Efficacy and safety of glibenclamide therapy after intracerebral haemorrhage (GATE-ICH): A multicentre, prospective, randomised, controlled, open-label, blinded-endpoint, phase 2 clinical trial

EClinicalMedicine, 2022
Summary: Background: Glibenclamide is a promising agent for treating brain oedema, but whether it improves clinical outcomes in patients with intracerebral haemorrhage (ICH) remains unclear.
Jian Qian
exaly   +3 more sources

A sensitive bioanalytical method for the simultaneous determination of amlodipine and glibenclamide [PDF]

Pharmaceutical Sciences Asia, 2022
Type 2 diabetes mellitus triggers hypertension as a complication. The use of amlodipine and glibenclamide drugs simultaneously results in a synergistic and effective lowering of blood sugar and blood pressure.
Febrina Amelia Saputri, Febrina Amelia Saputri, Aliya Nur Hasanah, Mutakin, Taofik Rusdiana, Ingrid Suryanti Surono, Rizky Abdulah, Rizky Abdulah   +7 more
doaj   +1 more source

Glibenclamide decreases ATP-induced intracellular calcium transient elevation via inhibiting reactive oxygen species and mitochondrial activity in macrophages. [PDF]

PLoS ONE, 2014
Increasing evidence has revealed that glibenclamide has a wide range of anti-inflammatory effects. However, it is unclear whether glibenclamide can affect the resting and adenosine triphosphate (ATP)-induced intracellular calcium ([Ca(2+)]i) handling in ...
Duo-ling Li, Zhi-yong Ma, Zhi-jie Fu, Ming-ying Ling, Chuan-zhu Yan, Yun Zhang   +5 more
doaj   +1 more source

Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients [PDF]

Pharmacia, 2021
Metformin and glibenclamide may have beneficial effects on the levels of trace elements in diabetic patients. The aim of the current study was to assess the effects of metformin and glibenclamide on the concentrations of copper (Cu), zinc (Zn) and ...
Jehan A. Mohammad, Ammar A. Y. Almulathanon, Fatimah Haitham Fathi   +2 more
doaj   +3 more sources

Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats.

PLoS ONE, 2021
Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH.
Tiffany F C Kung, Cassandra M Wilkinson, Christine A Dirks, Glen C Jickling, Frederick Colbourne   +4 more
doaj   +1 more source

PENGARUH PEMBERIAN EKSTRAK DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP GLIBENKLAMID DALAM MENURUNKAN KADAR GLUKOSA DARAH MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2016
The use of herbal medicines and synthetic drugs simultaneously carried out by diabetics for the maintenance of blood glucose levels, such as the use of glibenclamide and bay leaf.
Nur Hikmah, Yuliet Yuliet, Khildah Khaerati   +2 more
doaj   +1 more source

Comparative study between Metformin, Glibenclamide and their combination in newly diagnosed diabetic (type II) patients in Hawler City

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2012
Type 2 diabetes mellitus is a complex progressive disorder characterized by impaired insulin sensitivity, reduced insulin secretion and progressive failure of pancreatic β – cells.
Sazan D. S., Kassim J.S., Ansam N.H.
doaj   +1 more source

The Effect of KATP Channel Blocker Glibenclamide on CGRP-Induced Headache and Hemodynamic in Healthy Volunteers

Frontiers in Physiology, 2021
BackgroundCalcitonin gene-related peptide (CGRP) dilates cranial arteries and triggers headache. The CGRP signaling pathway is partly dependent on activation of ATP-sensitive potassium (KATP) channels. Here, we investigated the effect of the KATP channel
Hande Coskun, Fatima Azzahra Elbahi, Fatima Azzahra Elbahi, Mohammad Al-Mahdi Al-Karagholi, Hashmat Ghanizada, Majid Sheykhzade, Messoud Ashina, Messoud Ashina   +7 more
doaj   +1 more source