Results 41 to 50 of about 19,031 (203)

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

THERAPEUTIC EFFICACY OF ZINC OXIDE NANOPARTICLES IN DIABETIC RATS

Slovenian Veterinary Research, 2019
This study attempted to scrutinize the potential efficacy of zinc oxide nanoparticles (ZnONPs) and the standard oral hypoglycemic drug glibenclamide in streptozotocin (STZ) -nicotinamide induced diabetic rats.
Mohamed Kamel, Mohamed Khairy, Nada ELSadek, Mohamed Hussein   +3 more
doaj   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Plasma glibenclamide concentrations.

, 2015
(A) Glibenclamide concentration in plasma from individual female (white bars) and male (grey bars) mice implanted with a 21-day slow release 2.5mg glibenclamide pellet or a vehicle pellet. Data are mean±SEM of triplicate measurements.
Carolina Lahmann (777432), Frances M. Ashcroft (106321), Holger B. Kramer (221354)   +2 more
core   +1 more source

Augmentation of Antidiabetic Activity of Glibenclamide Microspheres Using S-Protected Okra Powered by QbD: Scintigraphy and In Vivo Studies

Pharmaceuticals, 2022
Successful drug delivery by mucoadhesive systems depends on the polymer type, which usually gets adherent on hydration. The intended polymers must sustain the association with biomembranes and preserve or accommodate the drug for an extended time.
Waleed Y. Rizg, N. Raghavendra Naveen, Mallesh Kurakula, Awaji Y. Safhi, Samar S. Murshid, Rayan Y. Mushtaq, Walaa A. Abualsunun, Majed Alharbi, Rana B. Bakhaidar, Alshaimaa M. Almehmady, Ahmad Salawi, Adel Al Fatease, Khaled M. Hosny   +12 more
doaj   +1 more source

The Effects of Glucagon‐Like Peptide‐1 Receptor Agonists and Sodium‐Glucose Co‐Transporter‐2 Inhibitors on Lean Body Mass in Humans: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Aims The use of pharmacotherapies with weight loss properties for the management of obesity and chronic disease are now routinely prescribed. We investigated the evidence from randomised‐controlled trials for the effects on lean body mass of glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) and sodium‐glucose co‐transporter‐2 inhibitors ...
Rishi Jobanputra, Jack A. Sargeant, Tatiana Plekhanova, Emily James, Abdullah Almaqhawi, David R. Webb, Melanie J. Davies, Thomas Yates   +7 more
wiley   +1 more source

Glibenclamide or Metformin Combined with Honey Improves Glycemic Control in Streptozotocin-Induced Diabetic Rats

International Journal of Biological Sciences, 2011
Diabetes mellitus is associated with deterioration of glycemic control and progressive metabolic derangements. This study investigated the effect of honey as an adjunct to glibenclamide or metformin on glycemic control in streptozotocin-induced diabetic ...
Omotayo Owomofoyon Erejuwa, Siti Amrah Sulaiman, Mohd Suhaimi Ab Wahab, Kuttulebbai Nainamohammed Salam Sirajudeen, Md Salzihan Md Salleh, Sunil Gurtu
doaj  

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, Volume 28, Issue 3, Page 855-867, June 2026.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Effects and Mechanisms of Stevioside on Metabolic Dysfunction‐Associated Steatotic Liver Disease

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
SV has the potential to prevent or treat MASLD by improving hepatic lipid metabolism, enhancing anti‐inflammatory and antioxidant capacity, and attenuating hepatic fibrosis. ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects more than 30% of adults globally and has emerged as a significant public health concern ...
Kangjun Li, Changfa Zhang, Lili Kang, Yunping Mu, Zemin Li, Jingyi Zhang, Guowei Li   +6 more
wiley   +1 more source

Mass spectra of glibenclamide and d₁₁-glibenclamide.

, 2015
(A,B) Mass spectra and structural formulae of glibenclamide (A) and d11-glibenclamide (B) in positive ionization mode obtained by direct injection ion trap mass spectrometry. Protonated molecular ions [M+H+] m/z (A) 494.1, (B) 505.1. Fragment ion m/z, (A,
Carolina Lahmann (777432), Frances M. Ashcroft (106321), Holger B. Kramer (221354)   +2 more
core   +1 more source