Results 21 to 30 of about 19,031 (203)

Do K_ATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? [PDF]

, 2000
The objective was to investigate whether myocardial adenosine triphosphate-sensitive K⁺ (K_ATP) channels open during the first 10 min of regional ischaemia in Langendorff-perfused rat hearts.
Northover, B.J., MacKenzie, I., Workman, A.J.   +2 more
core   +1 more source

Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells

International Journal of Endocrinology, 2019
Diabetes is a metabolic disease, partly due to hypoinsulinism, which affects ∼8% of the world’s adult population. Glibenclamide is known to promote insulin secretion by targeting β cells.
Jiali Zhou, Xincong Kang, Yushuang Luo, Yuju Yuan, Yanyang Wu, Meijun Wang, Dongbo Liu   +6 more
doaj   +1 more source

Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model

Natural Product Communications, 2015
Glibenclamide and thymoquinone plasma concentrations were analysed using a sensitive RP-HPLC method, and non-compartmental model pharmacokinetic parameters were calculated.
Ajaz Ahmad, Rao Muzaffar A. Khan, Khalid M. Alkharfy, Mohammad Raish, Fahad I. Al-Jenoobi, Abdullah M. Al-Mohizea   +5 more
doaj   +1 more source

Glibenclamide Alleviates LPS-Induced Acute Lung Injury through NLRP3 Inflammasome Signaling Pathway

Mediators of Inflammation, 2022
Glibenclamide displays an anti-inflammatory response in various pulmonary diseases, but its exact role in lipopolysaccharide- (LPS-) induced acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) remains unknown.
Jie Yang, Jiawen Yang, Xiaofang Huang, Huiqing Xiu, Songjie Bai, Jiahui Li, Zhijian Cai, Zhanghui Chen, Shufang Zhang, Gensheng Zhang   +9 more
doaj   +1 more source

Assessment of in vivo and in vitro genotoxicity of glibenclamide in eukaryotic cells. [PDF]

PLoS ONE, 2015
Glibenclamide is an oral hypoglycemic drug commonly prescribed for the treatment of type 2 diabetes mellitus, whose anti-tumor activity has been recently described in several human cancer cells.
Juliane Rocha de Sant'Anna, Claudinéia Conationi da Silva Franco, Paulo Cezar de Freitas Mathias, Marialba Avezum Alves de Castro-Prado   +3 more
doaj   +1 more source

The vascular effect of glibenclamide: A systematic review

Cephalalgia Reports, 2019
Objective: To systematically review the vascular effects of glibenclamide. Background: Infusion of adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channel opener (KCO) levcromakalim dilates cranial arteries and induces headache and migraine ...
Mohammad Al-Mahdi Al-Karagholi, Michael Sode, Aydin Gozalov, Messoud Ashina   +3 more
doaj   +1 more source

Extrapancreatic insulin effect of glibenclamide [PDF]

, 1991
In eight patients with uncomplicated non insulin dependent diabetes mellitus, serum insulin levels, serum C-peptide levels and blood glucose levels were measured before and after oral administration of glibenclamide 0.1 mg/kg body weight and a test meal,
Lely, A-J. (Aart-Jan) van der, Mulder, H.W. (H. W.), Schopman Sr., W.   +2 more
core   +1 more source

RETRACTED ARTICLE: Combined treatment of glibenclamide and CoCl2 decreases MMP9 expression and inhibits growth in highly metastatic breast cancer

Journal of Experimental & Clinical Cancer Research, 2013
Background To observe the influence of combination treatment with glibenclamide and CoCl2 on the growth and invasiveness of TA2 breast cancer, and to detect the protein and mRNA expression of MMP9.
Zhe Rong, Li Li, Fei Fei, Lailong Luo, Yang Qu   +4 more
doaj   +1 more source

Effects of Combination Treatment With Dipeptidyl Peptidase IV Inhibitor and Sulfonylurea on Glucose Levels in Rats

Journal of Pharmacological Sciences, 2004
The effects of orally administered dipeptidyl peptidase IV (DPP-IV) inhibitor on the glucose-lowering effect of glibenclamide are still unknown. We evaluated the effects of combination treatment with a long-lasting DPP-IV inhibitor, K579 ((S)-1-[4-methyl-
Kotaro Takasaki, Takao Nakajima, Kimihisa Ueno, Yuji Nomoto, Katsuya Higo   +4 more
doaj   +1 more source

Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial

BMC Pregnancy and Childbirth, 2017
Background Metformin is widely used to treat gestational diabetes (GDM), but many women remain hyperglycaemic and require additional therapy. We aimed to determine recruitment rate and participant throughput in a randomised trial of glibenclamide ...
Rebecca M. Reynolds, Fiona C. Denison, Ed Juszczak, Jennifer L. Bell, Jessica Penneycard, Mark W. J. Strachan, Robert S. Lindsay, Claire I. Alexander, Corinne D. B. Love, Sonia Whyte, Fiona Mackenzie, Ben Stenson, Jane E. Norman   +12 more
doaj   +1 more source