Results 31 to 40 of about 21,237 (199)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial

BMC Pregnancy and Childbirth, 2017
Background Metformin is widely used to treat gestational diabetes (GDM), but many women remain hyperglycaemic and require additional therapy. We aimed to determine recruitment rate and participant throughput in a randomised trial of glibenclamide ...
Rebecca M. Reynolds, Fiona C. Denison, Ed Juszczak, Jennifer L. Bell, Jessica Penneycard, Mark W. J. Strachan, Robert S. Lindsay, Claire I. Alexander, Corinne D. B. Love, Sonia Whyte, Fiona Mackenzie, Ben Stenson, Jane E. Norman   +12 more
doaj   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Glyburide reduces bacterial dissemination in a mouse model of melioidosis [PDF]

, 2013
Background: Burkholderia pseudomallei infection (melioidosis) is an important cause of community-acquired Gram-negative sepsis in Northeast Thailand, where it is associated with a ,40% mortality rate despite antimicrobial chemotherapy. We showed in a
Krause, Kathrin, Ivo Steinmetz (392595), Krause Kathrin, Hanna K de Jong, de Jong, Hanna K., Wiersinga W. Joost, van der Poll Tom, Kathrin Krause (473325), de Jong Hanna K., Koh, Gavin C. K. W., Bast Antje, Katrin Breitbach (473324), Koh Gavin C. K. W., Kager, Liesbeth M., Hanna K. de Jong (304424), W. Joost Wiersinga (33895), Peacock, Sharon J., Hoogendijk, Arjan J., Gavin C K W Koh, Liesbeth M Kager, Wiersinga, W. Joost, Kager, Liesbeth M, Tom van der Poll, Koh, Gavin C K W, W Joost Wiersinga, Antje Bast, Peacock, Sharon J, Gavin C. K. W. Koh (185751), Sharon J. Peacock (35782), Tassili A. Weehuizen (473323), Steinmetz Ivo, Kager Liesbeth M., Sharon J Peacock, Jong, Hanna K. de, Liesbeth M. Kager (367131), Tom van der Poll (33907), Bast, Antje, de Jong, Hanna K, Hoogendijk, Arjan J, Steinmetz, Ivo, Breitbach, Katrin, Breitbach Katrin, Weehuizen Tassili A., Kathrin Krause, Weehuizen, Tassili A., Arjan J. Hoogendijk (473326), Antje Bast (473327), Hoogendijk Arjan J., Wiersinga, W Joost, Peacock Sharon J., Tassili A Weehuizen, van der Poll, Tom, Katrin Breitbach, Arjan J Hoogendijk, Weehuizen, Tassili A, Ivo Steinmetz   +55 more
core   +3 more sources

Effects of Combination Treatment With Dipeptidyl Peptidase IV Inhibitor and Sulfonylurea on Glucose Levels in Rats

Journal of Pharmacological Sciences, 2004
The effects of orally administered dipeptidyl peptidase IV (DPP-IV) inhibitor on the glucose-lowering effect of glibenclamide are still unknown. We evaluated the effects of combination treatment with a long-lasting DPP-IV inhibitor, K579 ((S)-1-[4-methyl-
Kotaro Takasaki, Takao Nakajima, Kimihisa Ueno, Yuji Nomoto, Katsuya Higo   +4 more
doaj   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Nitric Oxide Releasing Multitarget Drugs [PDF]

, 2008
In the last few years, the “one-drug-one-target” paradigm has been shelved and numerous multi-target drugs have been projected and synthesised. Such compounds share two (or more) desired pharmacodynamic properties ensured by the presence of overlapping ...
MARTELLI, ALMA
core  

Exenatide versus glibenclamide in patients with diabetes.

, 2010
BACKGROUND: Incretin-based therapies have provided additional options for the treatment of type 2 diabetes mellitus. The aim of our study was to evaluate the effects of exenatide compared to glibenclamide on body weight, glycemic control, beta-cell ...
Querci F., CICERO, ARRIGO FRANCESCO GIUSEPPE, Ferrari I., Salvadeo S. A., Maffioli P., Franzetti I. G., . Ciccarelli L., Gadaleta G, Piccinni M. N., D'Angelo A., Derosa G., Ragonesi P. D.   +11 more
core   +2 more sources

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels

Epilepsia, EarlyView.
β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi, John Williamson, Jhanvi Patel, Samikksha Kumar, Huayu Sun, Lucy Dang Nguyen, Katarzyna Rękawek, Ifrah Zawar, Jaideep Kapur   +8 more
wiley   +1 more source