Results 51 to 60 of about 21,237 (199)

Genetic and Clinical Determinants of Variation in Drug Response in Type 2 Diabetes: Insights From the Scottish and UK Biobank Cohorts

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
S. Garg, R. Kitchen, R. Gupta, L. Donnelly, E. R. Pearson   +4 more
wiley   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide [PDF]

, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F., Standen, N.B., Yellon, D.M., Lawrence, C.L., Maddock, H.L., Mocanu, M.M.   +5 more
core  

Human placental transfer of xenobiotics in health and disease: New approach methodologies for developmental and reproductive toxicology testing and mathematical modelling

The Journal of Physiology, EarlyView.
Abstract figure legend New approach methodologies (NAMs) to test the pharmaco‐ and chemicokinetics of compound transfer across the human placental barrier in late pregnancy. Abstract This review addresses an important and timely topic at the intersection of placental biology with respect to barrier transfer kinetics, toxicology and mathematical ...
Paul Brownbill, Eleanor Doman
wiley   +1 more source

Mass spectra of glibenclamide and d₁₁-glibenclamide.

, 2015
(A,B) Mass spectra and structural formulae of glibenclamide (A) and d11-glibenclamide (B) in positive ionization mode obtained by direct injection ion trap mass spectrometry. Protonated molecular ions [M+H+] m/z (A) 494.1, (B) 505.1. Fragment ion m/z, (A,
Carolina Lahmann (777432), Frances M. Ashcroft (106321), Holger B. Kramer (221354)   +2 more
core   +1 more source

The antidiabetic drug glibenclamide exerts direct retinal neuroprotection: Glibenclamide exerts retinal neuroprotection

, 2020
International audienceSulfonylureas, widely used as hypoglycemic agents in adults with type 2 diabetes, have neuroprotective effects in preclinical models of central nervous system injury, and in children with neuropsychomotor impairments linked to ...
Picard, Émilie, Naud, Marie-Christine, Guegan, Justine, Polak, Michel, Gozalo, Claire, Daruich, Alejandra, Beltrand, Jacques, Savoldelli, Michèle, Radet, Lolita, Moulin, Alexandre, Djerada, Zoubir, Kermorvant-Duchemin, Elsa, Crisanti, Patricia, Jonet, Laurent, Jeanny, Jean-Claude, Berdugo, Marianne, Behar-Cohen, Francine, Delaunay, Kimberley   +17 more
core   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Glibenclamide quantification after intracranioventricular drug delivery.

, 2015
(A) Representative photograph of Nissl stained coronal section from a chronically ICV implanted rat (Scale bar: 500μm). (B) Glibenclamide concentrations in plasma (black circles) and CSF (grey circles) of rats given vehicle (n = 4) or glibenclamide (n ...
Carolina Lahmann (777432), Frances M. Ashcroft (106321), Holger B. Kramer (221354)   +2 more
core   +1 more source

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

GLIBENCLAMIDE TRANSETHOSOME PATCH FOR TRANSDERMAL DELIVERY: FORMULATION AND EVALUATIONS

, 2023
Objective: The glibenclamide transethosome patch is a patch containing glibenclamide encapsulated in nanoparticle-based vesicles that can improve the penetration of the compound into the skin.
CHAERUNISAA, ANIS YOHANA, ABDASSAH, MARLINE, YUSUF, NURUL ARFIYANTI, MAULUDIN, RACHMAT   +3 more
core   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, Volume 32, Issue 35, 19 September 2026.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source