Results 71 to 80 of about 19,031 (203)

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 953-963, April 2026.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Population pharmacokinetic modeling of glibenclamide in poorly controlled South African type 2 diabetic subjects

, 2016
Virendra Rambiritch,1 Poobalan Naidoo,2 Breminand Maharaj,1 Goonaseelan Pillai3 1University of KwaZulu-Natal, Durban, 2Department of Internal Medicine, RK Khan Regional Hospital, Chatsworth, South Africa; 3Novartis Pharma AG, Basel, Switzerland Aim:
Naidoo P, Rambiritch V, Maharaj B, Pillai G   +3 more
core  

GLIBENCLAMIDE TRANSETHOSOME PATCH FOR TRANSDERMAL DELIVERY: FORMULATION AND EVALUATIONS

, 2023
Objective: The glibenclamide transethosome patch is a patch containing glibenclamide encapsulated in nanoparticle-based vesicles that can improve the penetration of the compound into the skin.
CHAERUNISAA, ANIS YOHANA, ABDASSAH, MARLINE, YUSUF, NURUL ARFIYANTI, MAULUDIN, RACHMAT   +3 more
core  

Glibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3 inflammasome signaling pathway

, 2019
Hong Chen,1,2 Yongjie Ding,1,2 Wei Chen,1,2 Yun Feng,1,2 Guochao Shi1,21Department of Respiration and Critical Care Disease, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 20025, People’s Republic of China; 2Institute ...
Ding Y, Feng Y, Chen W, Shi G, Chen H
core  

Spectrofluorimetric method for the determination of glibenclamide in pharmaceutical formulations

, 2012
A sensitive spectrofluorimetric method for the determination of glibenclamide in its tablet formulations has been proposed. The method is based on the dissolving of glibenclamide in absolute ethanol and measuring the native fluorescence at 354 nm after ...
Baghdad Science Journal
core   +2 more sources

Effects of glibenclamide on memory retention of passive avoidance learning in rats

The Journal of Qazvin University of Medical Sciences, 2017
Background: Glucose increases memory in rats, and inhibit memory impairments produced by morphine. One mechanism by which glucose might act on memory via regulating the ATP-sensitive potassium channel.
MH. Esmaeili, F. Rostapishea, M. Mohammad Khanlo, F. Vadidar, Z. Bamdad   +4 more
doaj  

Development and validation of simple simultaneous analysis for amlodipine and glibenclamide by nonderivatization high-performance liquid chromatography-fluorescence

Journal of Advanced Pharmaceutical Technology & Research, 2018
Studies have shown that about 65% of diabetics have hypertension. Treatment for diabetic patients with hypertension is usually given a combination of drugs such as amlodipine (AML) and glibenclamide (GLI).
Febrina Amelia Saputri, Anisahtul Alawiyah, Ayu Brilliany Firsty, Sandra Megantara, Arif Satria Wira Kusuma, Taofik Rusdiana, Aliya Nur Hasanah, Mutakin Mutakin, Ingrid S Surono, Rizky Abdulah   +9 more
doaj   +1 more source

Glyburide reduces bacterial dissemination in a mouse model of melioidosis [PDF]

, 2013
Background: Burkholderia pseudomallei infection (melioidosis) is an important cause of community-acquired Gram-negative sepsis in Northeast Thailand, where it is associated with a ,40% mortality rate despite antimicrobial chemotherapy. We showed in a
Krause, Kathrin, Ivo Steinmetz (392595), Krause Kathrin, Hanna K de Jong, de Jong, Hanna K., Wiersinga W. Joost, van der Poll Tom, Kathrin Krause (473325), de Jong Hanna K., Koh, Gavin C. K. W., Bast Antje, Katrin Breitbach (473324), Koh Gavin C. K. W., Kager, Liesbeth M., Hanna K. de Jong (304424), W. Joost Wiersinga (33895), Peacock, Sharon J., Hoogendijk, Arjan J., Gavin C K W Koh, Liesbeth M Kager, Wiersinga, W. Joost, Kager, Liesbeth M, Tom van der Poll, Koh, Gavin C K W, W Joost Wiersinga, Antje Bast, Peacock, Sharon J, Gavin C. K. W. Koh (185751), Sharon J. Peacock (35782), Tassili A. Weehuizen (473323), Steinmetz Ivo, Kager Liesbeth M., Sharon J Peacock, Jong, Hanna K. de, Liesbeth M. Kager (367131), Tom van der Poll (33907), Bast, Antje, de Jong, Hanna K, Hoogendijk, Arjan J, Steinmetz, Ivo, Breitbach, Katrin, Breitbach Katrin, Weehuizen Tassili A., Kathrin Krause, Weehuizen, Tassili A., Arjan J. Hoogendijk (473326), Antje Bast (473327), Hoogendijk Arjan J., Wiersinga, W Joost, Peacock Sharon J., Tassili A Weehuizen, van der Poll, Tom, Katrin Breitbach, Arjan J Hoogendijk, Weehuizen, Tassili A, Ivo Steinmetz   +55 more
core   +1 more source

Glibenclamide Is Comparable to Target Temperature Management in Improving Survival and Neurological Outcome After Asphyxial Cardiac Arrest in Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundWe previously have shown that glibenclamide (GBC), a sulfonylurea receptor 1–transient receptor potential M4 (SUR1‐TRPM4) channel inhibitor, improves survival and neurological outcome after asphyxial cardiac arrest and cardiopulmonary ...
Kaibin Huang, Ziyue Wang, Yong Gu, Yafang Hu, Zhong Ji, Shengnan Wang, Zhenzhou Lin, Xing Li, Zuoshan Xie, Suyue Pan   +9 more
doaj   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide

, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F., Standen, N.B., Yellon, D.M., Lawrence, C.L., Maddock, H.L., Mocanu, M.M.   +5 more
core