Results 81 to 90 of about 21,237 (199)

Development and validation of simple simultaneous analysis for amlodipine and glibenclamide by nonderivatization high-performance liquid chromatography-fluorescence

Journal of Advanced Pharmaceutical Technology & Research, 2018
Studies have shown that about 65% of diabetics have hypertension. Treatment for diabetic patients with hypertension is usually given a combination of drugs such as amlodipine (AML) and glibenclamide (GLI).
Febrina Amelia Saputri, Anisahtul Alawiyah, Ayu Brilliany Firsty, Sandra Megantara, Arif Satria Wira Kusuma, Taofik Rusdiana, Aliya Nur Hasanah, Mutakin Mutakin, Ingrid S Surono, Rizky Abdulah   +9 more
doaj   +1 more source

Glibenclamide Is Comparable to Target Temperature Management in Improving Survival and Neurological Outcome After Asphyxial Cardiac Arrest in Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundWe previously have shown that glibenclamide (GBC), a sulfonylurea receptor 1–transient receptor potential M4 (SUR1‐TRPM4) channel inhibitor, improves survival and neurological outcome after asphyxial cardiac arrest and cardiopulmonary ...
Kaibin Huang, Ziyue Wang, Yong Gu, Yafang Hu, Zhong Ji, Shengnan Wang, Zhenzhou Lin, Xing Li, Zuoshan Xie, Suyue Pan   +9 more
doaj   +1 more source

Glibenclamide for the Treatment of Acute CNS Injury

Pharmaceuticals, 2013
First introduced into clinical practice in 1969, glibenclamide (US adopted name, glyburide) is known best for its use in the treatment of diabetes mellitus type 2, where it is used to promote the release of insulin by blocking pancreatic KATP ...
J. Marc Simard, Nicholas M. Caffes, Volodymyr Gerzanich, Jason K. Karimy, Adam Pampori, Cigdem Tosun, David B. Kurland   +6 more
doaj   +1 more source

Intravenous glibenclamide for cerebral oedema after large hemispheric stroke (CHARM): a phase 3, double-blind, placebo-controlled, randomised trial

Background No treatment is available to prevent brain oedema, which can occur after a large hemispheric infarction. Glibenclamide has previously been shown to improve functional outcome and reduce neurological or oedema-related death in patients younger ...
Collins, J, Lucas, N, Sheth, KN, Hinson, HE, Steiner, T, Molyneaux, BJ, Simard, JM, Toyoda, K, Albers, GW, Cordonnier, C, Campbell, BCV, Littauer, R, Wintermark, M, Nogueira, RG, Saver, JL, et al.   +15 more
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Trend 1 as depicted by Sandoz Glibenclamide.

, 2019
Trend 1 as depicted by Sandoz Glibenclamide.
Fatima Suleman (4118119), Rajatheran Moodley (7109351)   +1 more
core   +1 more source

Effect of P-glycoprotein inhibition on glibenclamide concentrations.

, 2015
(A) Individual glibenclamide concentrations in plasma of rats injected intraperitoneally with 50mg/kg glibenclamide in the presence of elacridar (n = 11; grey bars) or vehicle (n = 10; black bars).
Carolina Lahmann (777432), Frances M. Ashcroft (106321), Holger B. Kramer (221354)   +2 more
core   +1 more source

SOLUBILITY ENHANCEMENT OF GLIBENCLAMIDE USING MESOPOROUS SILICA [PDF]

, 2019
Glibenclamide is a BCS Class II drug and poses a major problem during formulation development. In the present study, adsorption onto various carriers was used to enhance the solubility of glibenclamide.
AKSHAY SONAWANE, Mittal, Swati, MANGESH KHUNE   +2 more
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The Effect of Glibenclamide on the Functional Activity of К_ATP Channels of Cerebral Arteries in Rats with Streptozotocin Diabetes Mellitus

Сахарный диабет
BACKGROUND: In the treatment of diabetes mellitus (DM) for a persistent reduction in blood glucose levels it was widely used glibenclamide — a KATP channels blocker. However, its effects on cerebral circulation have been studied very little.
I. B. Sokolova, G. I. Lobov
doaj   +1 more source

Sensitivity of oocyte-expressed epithelial Na+ channel to glibenclamide [PDF]

, 2003
The effect of glibenclamide on heterologously expressed amiloride-sensitive sodium channels (ENaCs) was investigated in Xenopus oocytes. The ENaC is a heteromer and consists of α-, β- and γ-subunits and the α- and β-subunits have previously been shown to
Schnizler, Mikael, Clauss, Wolfgang, Berk, Andreas   +2 more
core   +1 more source

Solubility Enhancement of Antidiabetic Drug: Glibenclamide [PDF]

, 2015
INTRODUCTION: As a result of the modern ‘high throughput’ approach to drug discovery, it has been estimated that up to 70% of the new chemical entities(NCEs) entering drug development possess insufficient aqueous solubility to allow adequate and ...
Madhankumar, K
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