Results 101 to 110 of about 19,031 (203)

Wet granulation to overcome liquisolid technique issues of poor flowability and compactibility: A study to enhance Glibenclamide dissolution [PDF]

The aim of this study is to apply wet granulation on liquisolid powders to overcome issues of poor powder flowability and compressibility especially with using high viscosity liquid vehicles.
Javaheri, H., Carter, Paul, Elkordy, Amal   +2 more
core  

Uptake of tritiated glibenclamide by endocrine and exocrine pancreas.

, 2000
Tritiated glibenclamide binds to specific receptors and is internalized in pancreatic insulin-producing B-cells. We investigated, therefore, whether tritiated glibenclamide could be used to preferentially label the endocrine, as distinct from exocrine ...
Malaisse, Willy, Malaisse Lagae, Francine, Ladrière, Laurence   +2 more
core   +1 more source

The effect of glibenclamide on the pathogenesis of melioidosis

, 2012
Melioidosis is an important cause of community-acquired sepsis, endemic to Southeast Asia and Northern Australia. Melioidosis is caused by the soil saprophyte, Burkholderia pseudomallei, a motile Gram-negative bacillus, and is associated with a mortality

core   +1 more source

Comparative Effects of Glibenclamide and Metformin on C-Reactive Protein and Oxidant/Antioxidant Status in Patients with Type II Diabetes Mellitus

Sultan Qaboos University Medical Journal, 2012
Objectives: This study aimed to compare the effects of metformin and glibenclamide on high sensitivity serum C-reactive protein (hs-CRP) and oxidative stress, represented by serum malondialdehyde (MDA) and total antioxidant status (TAS) in newly ...
Alaa A.A. Abdulkadir, Imad A-J. Thanoon
doaj  

Vasorelaxant effects of glibenclamide on rat thoracic aorta

, 2005
The purpose of this study was to investigate the effect of glibenclamide, a selective ATP-sensitive K+ (KATP) channel blocker, on agonist-induced contractions in isolated rat aortic rings.
Ertuna E., Yasa, Mukadder, Ertuna, Elif, Yasa M.   +3 more
core  

SOLUBILITY ENHANCEMENT OF GLIBENCLAMIDE USING MESOPOROUS SILICA

, 2019
Glibenclamide is a BCS Class II drug and poses a major problem during formulation development. In the present study, adsorption onto various carriers was used to enhance the solubility of glibenclamide.
AKSHAY SONAWANE, Mittal, Swati, MANGESH KHUNE   +2 more
core  

Pharmaceutical agents targeting K_ATP channel modulate sweet taste sensitivity in mice. [PDF]

J Physiol Sci
Sawai C, Wang K, Horie K, Mitoh Y, Ueda H, Kamioka H, Yoshida R.   +6 more
europepmc   +1 more source

Partial restoration of counterregulatory circulating glucagon by dapagliflozin and low-dose glibenclamide in men with type 1 diabetes: in vitro studies and randomised clinical crossover trial. [PDF]

EBioMedicine
Gao R, Spiliotis I, Dou H, Hill TG, Kothegala L, Miranda C, Abiakam N, Coleman RL, White S, Adler A, Rorsman P.   +10 more
europepmc   +1 more source

Inhibition of SUR1-TRPM4 attenuates astrocyte swelling and reactivity under oxygen-glucose deprivation/reoxygenation. [PDF]

PLoS One
Zhao Y, Pakaprot N, Sutiwisesak R, Vattarakorn U, Tapechum S.   +4 more
europepmc   +1 more source

Discovery of novel quinazoline-sulfonamide derivatives with promising antidiabetic activity. [PDF]

Front Chem
Zayed MF, Muhammad Y, Alqurain AA, Banafa MAA, Omar AM.   +4 more
europepmc   +1 more source