Results 91 to 100 of about 19,031 (203)

Dissolution test for glibenclamide tablets

, 2007
The aim of this work is to develop and validate a dissolution test for glibenclamide tablets. Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and ...
Maurilio José Lara-Filho, Marlene Maria Fregonezi-Nery, Elisabeth Aparecida dos Santos Gianotto, Renata Pires Arantes, Alexandre Cezar Saraiva Casimiro Filho   +4 more
core   +1 more source

Intranasal Mucoadhesive In Situ Gel of Glibenclamide-Loaded Bilosomes for Enhanced Therapeutic Drug Delivery to the Brain

Pharmaceutics
Background: The neuroprotective efficacy of glibenclamide (GLIB) has been demonstrated in multiple rodent models of ischemia, hemorrhagic stroke, traumatic brain damage, spinal cord injury, and metastatic brain tumors.
Meenakshi Tripathi, Laxmi Gharti, Amit Bansal, Hemlata Kaurav, Sandeep Sheth   +4 more
doaj   +1 more source

Engineered Glibenclamide-Loaded Nanovectors Hamper Inflammasome Activation in an Ex Vivo Alzheimer’s Disease Model—A Novel Potential Therapy for Neuroinflammation: A Pilot Study

Biomolecules
Background: Inflammasomes regulate the activation of caspases resulting in inflammation; inflammasome activation is dysregulated in Alzheimer’s disease (AD) and plays a role in the pathogenesis of this condition. Glibenclamide, an anti-inflammatory drug,
Francesca La Rosa, Simone Agostini, Elisabetta Bolognesi, Ivana Marventano, Roberta Mancuso, Franca Rosa Guerini, Ambra Hernis, Lorenzo Agostino Citterio, Federica Piancone, Pietro Davide Trimarchi, Jorge Navarro, Federica Rossetto, Arianna Amenta, Pierfausto Seneci, Silvia Sesana, Francesca Re, Mario Clerici, Marina Saresella   +17 more
doaj   +1 more source

Sensitivity of oocyte-expressed epithelial Na+ channel to glibenclamide

, 2003
The effect of glibenclamide on heterologously expressed amiloride-sensitive sodium channels (ENaCs) was investigated in Xenopus oocytes. The ENaC is a heteromer and consists of α-, β- and γ-subunits and the α- and β-subunits have previously been shown to
Schnizler, Mikael, Clauss, Wolfgang, Berk, Andreas   +2 more
core   +1 more source

Comparative Effects of Metformin and Glibenclamide on Aortic Reactivity to Vasodilator and Vasoconstrictor Agents in STZ-Induced Diabetic Rats: Comparative effect of metformin and glibenclamide in diabetic rats

, 2018
Diabetes is an important risk factor for cardiovascular events. Endothelial dysfunction is the main cause of disability and death in diabetic patients.
Mohebbati, Reza, Hayatdavoudi, Parichehr, Abbasnezhad, Abbasali   +2 more
core   +1 more source

Implications of NLRP3 Suppression Using Glibenclamide and miR-223 against Colorectal Cancer

Pharmaceuticals
The NLR family pyrin domain containing 3 (NLRP3) promotes the growth of colorectal cancer (CRC). However, the therapeutic effect of NLRP3 inhibition on CRC cell progression is controversial. This study comparatively investigated the therapeutic effect of
Shaimaa Hamza, Ekaterina E. Garanina, Layaly Shkair, Mohammad Alsaadi, Svetlana F. Khaiboullina, Gulcin Tezcan   +5 more
doaj   +1 more source

Quercetin reduce cardiomyocytes damage in type 2 diabetic rats [PDF]

Universa Medicina, 2014
Background Diabetes mellitus (DM) is a group of metabolic diseases which are characterized by hyperglycemia, resulting in various complications. A major macrovascular complication of DM is cardiac failure due to cardiomyopathy.
Asri Hendrawati, Nadhir
doaj  

Glibenclamide attenuates adenosine-induced bradycardia and coronary vasodilatation

, 1991
The effects of the ATP-sensitive K(+)-channel blocker glibenclamide on the cardiovascular responses to adenosine in dogs were determined. Adenosine (0.01-20 mumol/kg iv) caused coronary vasodilatation, arterial hypotension, and bradycardia in dogs with ...
T. H. Hintze, F. L. Belloni
core   +1 more source

PRENATAL DIAGNOSIS OF ROBERT/SC SYNDROME IN A DIABETIC MOTHER WITH A HISTORY OF MEBENDAZOLE AND GLIBENCLAMIDE INTAKE [PDF]

Acta Medica Iranica, 2003
The Robert/SC (pseudothalidomide) syndrome is a rare autosomal recessive disorder, associated with phocomelia and craniofacial abnormalities. An anomalous fetus with lower limb phocomelia and micromelia, lumbar myeloschisis, upper limb and ribs defects ...
M. Pourissa, S. Refahi N. Garaaghagi
doaj  

A Study of Transdermal Delivery of Glibenclamide Using Iontophoresis

, 2010
Purpose: To assess iontophoretic transdermal delivery of glibenclamide across pigskin for its transdermal development. Methods: In vitro iontophoretic transdermal delivery of glibenclamide across the pigskin was investigated at three different drug ...
Ghosh, B, Nayak, S, Soni, V, A Jain, B Ghosh, S Nayak, V Soni, Jain, A   +7 more
core   +1 more source