Results 91 to 100 of about 21,237 (199)

Glibenclamide treatment prevents the development of diabetes in NOD mice.

, 2016
a) All mice had normal blood glucose levels at week 5. Thereafter, the proportion of untreated animals, which remained normoglycaemic, rapidly dropped with time (open symbols).
Helena Pontes (148291), Chantal Mathieu (93158), Conny Gysemans (411741), Joanna Bou Saab (3599567), Smaragda Lamprianou (3599570), Paolo Meda (134110)   +5 more
core   +1 more source

Dissolution test for glibenclamide tablets

, 2007
The aim of this work is to develop and validate a dissolution test for glibenclamide tablets. Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and ...
Maurilio José Lara-Filho, Marlene Maria Fregonezi-Nery, Elisabeth Aparecida dos Santos Gianotto, Renata Pires Arantes, Alexandre Cezar Saraiva Casimiro Filho   +4 more
core   +1 more source

Intranasal Mucoadhesive In Situ Gel of Glibenclamide-Loaded Bilosomes for Enhanced Therapeutic Drug Delivery to the Brain

Pharmaceutics
Background: The neuroprotective efficacy of glibenclamide (GLIB) has been demonstrated in multiple rodent models of ischemia, hemorrhagic stroke, traumatic brain damage, spinal cord injury, and metastatic brain tumors.
Meenakshi Tripathi, Laxmi Gharti, Amit Bansal, Hemlata Kaurav, Sandeep Sheth   +4 more
doaj   +1 more source

Glibenclamide decelerates the responses of coronary regulation in the goat

, 1994
The role of blocking ATP-sensitive potassium (KATP) channels by glibenclamide on the dynamic responses of coronary resistance to abrupt changes in perfusion pressure and heart rate was investigated.
Dankelman, J., van der Ploeg, C. P., Spaan, J. A.   +2 more
core   +2 more sources

Engineered Glibenclamide-Loaded Nanovectors Hamper Inflammasome Activation in an Ex Vivo Alzheimer’s Disease Model—A Novel Potential Therapy for Neuroinflammation: A Pilot Study

Biomolecules
Background: Inflammasomes regulate the activation of caspases resulting in inflammation; inflammasome activation is dysregulated in Alzheimer’s disease (AD) and plays a role in the pathogenesis of this condition. Glibenclamide, an anti-inflammatory drug,
Francesca La Rosa, Simone Agostini, Elisabetta Bolognesi, Ivana Marventano, Roberta Mancuso, Franca Rosa Guerini, Ambra Hernis, Lorenzo Agostino Citterio, Federica Piancone, Pietro Davide Trimarchi, Jorge Navarro, Federica Rossetto, Arianna Amenta, Pierfausto Seneci, Silvia Sesana, Francesca Re, Mario Clerici, Marina Saresella   +17 more
doaj   +1 more source

Implications of NLRP3 Suppression Using Glibenclamide and miR-223 against Colorectal Cancer

Pharmaceuticals
The NLR family pyrin domain containing 3 (NLRP3) promotes the growth of colorectal cancer (CRC). However, the therapeutic effect of NLRP3 inhibition on CRC cell progression is controversial. This study comparatively investigated the therapeutic effect of
Shaimaa Hamza, Ekaterina E. Garanina, Layaly Shkair, Mohammad Alsaadi, Svetlana F. Khaiboullina, Gulcin Tezcan   +5 more
doaj   +1 more source

Quercetin reduce cardiomyocytes damage in type 2 diabetic rats [PDF]

Universa Medicina, 2014
Background Diabetes mellitus (DM) is a group of metabolic diseases which are characterized by hyperglycemia, resulting in various complications. A major macrovascular complication of DM is cardiac failure due to cardiomyopathy.
Asri Hendrawati, Nadhir
doaj  

PRENATAL DIAGNOSIS OF ROBERT/SC SYNDROME IN A DIABETIC MOTHER WITH A HISTORY OF MEBENDAZOLE AND GLIBENCLAMIDE INTAKE [PDF]

Acta Medica Iranica, 2003
The Robert/SC (pseudothalidomide) syndrome is a rare autosomal recessive disorder, associated with phocomelia and craniofacial abnormalities. An anomalous fetus with lower limb phocomelia and micromelia, lumbar myeloschisis, upper limb and ribs defects ...
M. Pourissa, S. Refahi N. Garaaghagi
doaj  

Comparative Effects of Glibenclamide and Metformin on C-Reactive Protein and Oxidant/Antioxidant Status in Patients with Type II Diabetes Mellitus

Sultan Qaboos University Medical Journal, 2012
Objectives: This study aimed to compare the effects of metformin and glibenclamide on high sensitivity serum C-reactive protein (hs-CRP) and oxidative stress, represented by serum malondialdehyde (MDA) and total antioxidant status (TAS) in newly ...
Alaa A.A. Abdulkadir, Imad A-J. Thanoon
doaj  

Vasorelaxant effects of glibenclamide on rat thoracic aorta

, 2005
The purpose of this study was to investigate the effect of glibenclamide, a selective ATP-sensitive K+ (KATP) channel blocker, on agonist-induced contractions in isolated rat aortic rings.
Ertuna E., Yasa, Mukadder, Ertuna, Elif, Yasa M.   +3 more
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