Results 61 to 70 of about 21,237 (199)

Nanomedicine for the Treatment of Pediatric Type 2 Diabetes: Progress, Challenges, and Translational Perspectives

open access: yesAdvanced Therapeutics, Volume 9, Issue 9, September 2026.
Overview of pharmaceutical nanocarriers in diabetes, illustrating applications of nanotechnology including enhanced drug and targeted drug delivery and nanosensors for glucose monitoring and diagnosis. ABSTRACT Pediatric type 2 diabetes mellitus (T2DM) is rapidly emerging as a critical global health concern, driven largely by rising childhood obesity ...
Nnamdi Ikemefuna Okafor   +2 more
wiley   +1 more source

PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE [PDF]

open access: yes, 2014
Simple, reliable and reproducible method was used for the preparation of polymeric nanoparticles of Glibenclamide. The formulation was prepared by solvent evaporation method using magnetic stirrer with overnight stirring and the same was then evaluated ...
Naha, Anup   +5 more
core   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

open access: yesAdvanced Science, Volume 13, Issue 54, 28 September 2026.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou   +11 more
wiley   +1 more source

Safety and efficacy of glibenclamide on cerebral oedema following aneurysmal subarachnoid haemorrhage: a randomised, double-blind, placebo-controlled clinical trial

open access: yesStroke and Vascular Neurology
Background Glibenclamide has garnered attention due to its multifaceted neuroprotective effects in cases of acute central nervous system injury.
Hao Zhao   +7 more
doaj   +1 more source

PRENATAL DIAGNOSIS OF ROBERT/SC SYNDROME IN A DIABETIC MOTHER WITH A HISTORY OF MEBENDAZOLE AND GLIBENCLAMIDE INTAKE [PDF]

open access: yes
The Robert/SC (pseudothalidomide) syndrome is a rare autosomal recessive disorder, associated with phocomelia and craniofacial abnormalities. An anomalous fetus with lower limb phocomelia and micromelia, lumbar myeloschisis, upper limb and ribs defects ...
رفاهی, سهیلا   +2 more
core  

Effect of pellet drug dose on plasma glibenclamide concentration.

open access: yes, 2015
(A) Glibenclamide concentration in plasma from individual male mice implanted with a vehicle (n = 15 animals), a 0.25mg glibenclamide (n = 5 animals), a 2.5mg glibenclamide (n = 7 animals) or a 25mg glibenclamide pellet (n = 5 animals). (B) Glibenclamide
Carolina Lahmann (777432)   +2 more
core   +1 more source

Spectrofluorimetric method for the determination of glibenclamide in pharmaceutical formulations [PDF]

open access: yes, 2012
A sensitive spectrofluorimetric method for the determination of glibenclamide in its tablet formulations has been proposed. The method is based on the dissolving of glibenclamide in absolute ethanol and measuring the native fluorescence at 354 nm after ...
Baghdad Science Journal
core   +3 more sources

Haemostasiologic effects of various glucose-lowering medications in type 2 diabetes mellitus

open access: yesКардиоваскулярная терапия и профилактика, 2010
Aim. To evaluate the effects of insulin and other glucose-lowering medications on platelet function and coagulation haemostasis in patients with Type 2 diabetes mellitus (DM-2). Material and methods.
G. G. Petrik, S. A. Pavlishchuk
doaj  

Glibenclamide, a Sur1-Trpm4 antagonist, does not improve outcome after collagenase-induced intracerebral hemorrhage.

open access: yesPLoS ONE, 2019
The sulfonylurea 1 transient receptor potential melastatin 4 (Sur1-Trpm4) receptor is selectively expressed after intracerebral hemorrhage (ICH). This upregulation contributes to increases in intracellular sodium.
Cassandra M Wilkinson   +3 more
doaj   +1 more source

Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization

open access: yesFrontiers in Immunology, 2018
Tuberculosis (TB) is a global public health problem, which is caused by Mycobacterium tuberculosis (Mtb). Type 2 diabetes mellitus (T2DM) is one of the leading predisposing factors for development of TB after HIV/AIDS. Glibenclamide is a widely used anti-
Chidchamai Kewcharoenwong   +9 more
doaj   +1 more source

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