Results 61 to 70 of about 5,030 (211)
KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy
Molecular Pain, 2010 Background ATP-sensitive potassium (KATP) channels in neurons mediate neuroprotection, they regulate membrane excitability, and they control neurotransmitter release.
Gemes Geza +8 more
doaj +1 more source
IL-1beta promotes the age-associated decline of beta cell function
iScience, 2021 Summary: Aging is the prime risk factor for the development of type 2 diabetes. We investigated the role of the interleukin-1 (IL-1) system on insulin secretion in aged mice.
Marianne Böni-Schnetzler +7 more
doaj +1 more source
Video2_Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels.MP4
, 2021 ATP-sensitive potassium (KATP) channels consist of an inwardly rectifying K+ channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K+ permeation directly to the metabolic state of the cell ...
Sarala Pellikan (11254941) +2 more
core +1 more source
Pharmaceuticals, 2023 Migraine is a highly disabling pain disorder with huge socioeconomic and personal costs. It is genetically heterogenous leading to variability in response to current treatments and frequent lack of response. Thus, new treatment strategies are needed.
Tino Dyhring +3 more
doaj +1 more source
Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.Genetic variations in T2DM, including key metabolic and insulin‐related genes, influence disease risk, insulin resistance, and drug response. Understanding these polymorphisms enables precision medicine, optimising therapy and improving glycaemic control across diverse populations.
Nokwanda N. Ngcobo, Ntethelelo H. Sibiya
wiley +1 more source
Frontiers in Pharmacology, 2022 Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit of the IKATP potassium channel ...
Marien J. C. Houtman +5 more
doaj +1 more source
Focus on Kir6.2: a key component of the ATP-sensitive potassium channel
Journal of Molecular and Cellular Cardiology, 2005 ATP-sensitive potassium (K(ATP)) channels are found in a wide variety of cell types where they couple cell metabolism to electrical activity. In glucose-sensing tissues, these channels respond to fluctuating changes in blood glucose concentration, but in other tissues they are activated only under ischemic conditions or in response to hormonal ...
Haider, S +4 more
openaire +2 more sources
, 2005 BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M +27 more
core +1 more source
Voltage-dependent gating in a "voltage sensor-less" ion channel.
PLoS Biology, 2010 The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity.
Harley T Kurata +4 more
doaj +1 more source
Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels
Channels, 2022 ATP-sensitive K+ (KATP) channel couples membrane excitability to intracellular energy metabolism. Maintaining KATP channel surface expression is key to normal insulin secretion, blood pressure and cardioprotection.
Bo Yang +6 more
doaj +1 more source