Results 41 to 50 of about 5,030 (211)
Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrests Growth of Gynecologic Cancers
Frontiers in Pharmacology, 2020 Gynecologic cancers are among the most lethal cancers found in women, and, advanced stage cancers are still a treatment challenge. Ion channels are known to contribute to cellular homeostasis in all cells and mounting evidence indicates that ion channels
Daniela Fukushiro-Lopes +11 more
doaj +1 more source
Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM
eLife, 2019 ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis.
Gregory M Martin +7 more
doaj +1 more source
Control of Rectification and Gating of Cloned KATP Channels by the Kir6.2 Subunit [PDF]
The Journal of General Physiology, 1997 KATP channels are a functional complex of sulphonylurea receptor (SUR1, SUR2) and inward rectifier K+ (Kir6.1, Kir6.2) channel subunits. We have studied the role of the putative pore forming subunit (Kir6.2) in regulation of rectification and gating of KATP channels generated by transfection of SUR1 and Kir6.2 cDNAs in COSm6 cells.
S, Shyng, T, Ferrigni, C G, Nichols
openaire +2 more sources
Biochemistry and Biophysics Reports, 2018 Some recent studies associated insulin therapy with negative cardiovascular events and shorter lifespan. SUR2A, a KATP channel subunit, regulate cardioprotection and cardiac ageing.
Qingyou Du +6 more
doaj +1 more source
iNew Medicine, Volume 2, Issue 2, June 2026.ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen +6 more
wiley +1 more source
Cytoplasmic Vestibule of the Weak Inward Rectifier Kir6.2 Potassium Channel [PDF]
Journal of Biological Chemistry, 2002 Intracellular application of certain charged methanethiosulfonate (MTS) reagents modified and irreversibly inhibited Kir6.2 channels when cysteine substitutions were introduced at positions Ile-210, Ile-211, or Ser-212 within the putative cytoplasmic region. Inhibition depends on the spatial dimensions of the MTS reagents.
Yijun, Cui, Wenxia, Wang, Zheng, Fan
openaire +2 more sources
Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade. [PDF]
PLoS ONE, 2011 Cyclic GMP (cGMP)-dependent protein kinase (PKG) is recognized as an important signaling component in diverse cell types. PKG may influence the function of cardiac ATP-sensitive potassium (K(ATP)) channels, an ion channel critical for stress adaptation ...
Yongping Chai +2 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud +9 more
wiley +1 more source
Age-dependent changes in the exocytotic efficacy in Kir6.2 ablated mouse pancreatic beta cells [PDF]
, 2014 ATP-sensitive K+ channels (K channels) regulate cellular energy metabolism in control of membrane excitability. The KATP channel of pancreatic β-cells is composed of SUR1 and Kir6.2 subunits. Kir6.2-/- mice have a defective KATP channel and can mimic the
Tsiaze, Ernest Beaudelaire
core +1 more source
DataSheet1_Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels.PDF
, 2021 ATP-sensitive potassium (KATP) channels consist of an inwardly rectifying K+ channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K+ permeation directly to the metabolic state of the cell ...
Sarala Pellikan (11254941) +2 more
core +1 more source