Results 21 to 30 of about 5,030 (211)

Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission

Frontiers in Pharmacology, 2021
Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson’s disease (PD). As the most abundant cells of the brain and active participants in neuroinflammatory responses, astrocytes largely propagate inflammatory signals and ...
Nanshan Song, Hong Zhu, Rong Xu, Jiaqi Liu, Yinquan Fang, Jing Zhang, Jianhua Ding, Gang Hu, Gang Hu, Ming Lu, Ming Lu   +10 more
doaj   +1 more source

Kir6.2 is required for adaptation to stress [PDF]

Proceedings of the National Academy of Sciences, 2002
Reaction to stress requires feedback adaptation of cellular functions to secure a response without distress, but the molecular order of this process is only partially understood. Here, we report a previously unrecognized regulatory element in the general adaptation syndrome.
Leonid V, Zingman, Denice M, Hodgson, Peter H, Bast, Garvan C, Kane, Carmen, Perez-Terzic, Richard J, Gumina, Darko, Pucar, Martin, Bienengraeber, Petras P, Dzeja, Takashi, Miki, Susumu, Seino, Alexey E, Alekseev, Andre, Terzic   +12 more
openaire   +2 more sources

Molecular Basis for Kir6.2 Channel Inhibition by Adenine Nucleotides [PDF]

Biophysical Journal, 2003
K(ATP) channels are comprised of a pore-forming protein, Kir6.x, and the sulfonylurea receptor, SURx. Interaction of adenine nucleotides with Kir6.2 positively charged amino acids such as K185 and R201 on the C-terminus causes channel closure. Substitution of these amino acids with other positively charged residues had small effects on inhibition by ...
Ribalet, Bernard, John, Scott A., Weiss, James N.   +2 more
openaire   +5 more sources

KATP channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapies

Frontiers in Endocrinology, 2023
Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh, Assmaa ElSheikh, Show-Ling Shyng   +2 more
doaj   +1 more source

Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: A mechanistic study [PDF]

Journal of General Physiology, 2014
Sulfonylureas, which stimulate insulin secretion from pancreatic β-cells, are widely used to treat both type 2 diabetes and neonatal diabetes. These drugs mediate their effects by binding to the sulfonylurea receptor subunit (SUR) of the ATP-sensitive K+ (KATP) channel and inducing channel closure.
Peter Proks, Heidi de Wet, Frances M. Ashcroft   +2 more
openaire   +2 more sources

The effect of signal pathways on the neural KATP subunits SUR1/Kir6.2 expression induced by Aβ1-42

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To investigate the potential signal transduction mechanism of β⁃amyloid protein1-42 (Aβ1-42) induced up⁃regulation of ATP sensitive potassium channel KATP subunit SUR1/Kir6.2 proteins expression.
LI Yan⁃ju, ZHANG Ge , WANG Xiao⁃jing, XING Xiao⁃min, MA Guo⁃zhao   +4 more
doaj   +1 more source

Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach [PDF]

Genomics & Informatics, 2014
Among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. Several target proteins have been identified, and the etiology causing diabetes has been reasonably well studied. But, there is still
Manaswini Jagadeb, V Badireenath Konkimalla, Surya Narayan Rath, Rohit Pritam Das   +3 more
doaj   +1 more source

Effects of Sodium Azide, Barium Ion, d-Amphetamine and Procaine on Inward Rectifying Potassium Channel 6.2 Expressed in Xenopus Oocytes

Journal of the Formosan Medical Association, 2008
Background/Purpose: Inward rectifying potassium channel 6.2 (Kir6.2 Δ C26 channel) is closely related to ATP-sensitive potassium channels. Whether sodium azide, barium ion, d-amphetamine or procaine acts directly on the Kir6.2 Δ C26 channel remains ...
Fan-Lu Kung, Jung-Lung Tsai, Chien-Hsing Lee, Kuo-Long Lou, Chih-Yung Tang, Horng-Huei Liou, Kuan-Ling Lu, Yi-Hung Chen, Wun-Jheng Wang, Ming-Cheng Tsai   +9 more
doaj   +1 more source

Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves

iScience, 2022
Summary: Glucose-responsive ATP-sensitive potassium channels (KATP) are expressed in a variety of tissues including nervous systems. The depolarization of the membrane potential induced by glucose may lead to hyperexcitability of neurons and induce ...
Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya   +18 more
doaj   +1 more source

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

eLife, 2020
Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts KATP. Mg-nucleotide binding to SUR1 stimulates KATP. In the absence of Mg2+
Samuel G Usher, Frances M Ashcroft, Michael C Puljung   +2 more
doaj   +1 more source