Results 11 to 20 of about 5,030 (211)
Chloroquine Decreased Kir6.2 Immunoreactivity in Chronic Hypoxic Heart
Bezmiâlem Science, 2022 Objective:Experimental and clinical studies indicate that cardiovascular system diseases have the highest mortality rate. One of the major factors underlying this high mortality rate is hypoxia.
Arda Kaan ÜNER +7 more
doaj +7 more sources
CL-705G: a novel chemical Kir6.2-specific KATP channel opener [PDF]
Frontiers in Pharmacology, 2023 Background: KATP channels have diverse roles, including regulation of insulin secretion and blood flow, and protection against biological stress responses and are excellent therapeutic targets.
Ivan Gando +6 more
doaj +4 more sources
An In-Frame Deletion in Kir6.2 (KCNJ11) Causing Neonatal Diabetes Reveals a Site of Interaction between Kir6.2 and SUR1 [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2009 Activating mutations in genes encoding the Kir6.2 (KCNJ11) and SUR1 (ABCC8) subunits of the pancreatic ATP-sensitive K(+) channel are a common cause of permanent neonatal diabetes (PNDM). All Kir6.2 mutations identified to date are missense mutations. We describe here a novel in-frame deletion (residues 28-32) in Kir6.2 in a heterozygous patient with ...
Craig, T +5 more
openaire +6 more sources
Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels [PDF]
Frontiers in Molecular Biosciences, 2021 ATP-sensitive potassium (KATP) channels consist of an inwardly rectifying K+ channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K+ permeation directly to the metabolic state of the cell ...
Michael Bründl +2 more
doaj +4 more sources
Involvement of the N‐terminus of Kir6.2 in coupling to the sulphonylurea receptor
The Journal of Physiology, 1999 1. ATP-sensitive potassium (KATP) channels are composed of pore-forming Kir6.2 and regulatory SUR subunits. ATP inhibits the channel by interacting with Kir6.2, while sulphonylureas block channel activity by interaction with a high-affinity site on SUR1 and a low-affinity site on Kir6.2.
Reimann, F +3 more
openaire +4 more sources
Phentolamine block of K ATP channels is mediated by Kir6.2 [PDF]
Proceedings of the National Academy of Sciences, 1997 The ATP-sensitive K + -channel (K ATP channel) plays a key role in insulin secretion from pancreatic β cells. It is closed both by glucose metabolism and the sulfonylurea drugs that are used in the treatment of noninsulin-dependent diabetes mellitus, thereby initiating a membrane ...
Proks, P, Ashcroft, F
openaire +3 more sources
Activating Mutations in Kir6.2 and Neonatal Diabetes [PDF]
Diabetes, 2005 Closure of ATP-sensitive K+ channels (KATP channels) in response to metabolically generated ATP or binding of sulfonylurea drugs stimulates insulin release from pancreatic β-cells. Heterozygous gain-of-function mutations in the KCJN11 gene encoding the Kir6.2 subunit of this channel are found in ∼47% of patients diagnosed with permanent diabetes at ...
Andrew T. Hattersley +1 more
openaire +2 more sources
Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells [PDF]
International Journal of Photoenergy, 2014 Background and Objective. ATP-sensitive potassium (KATP) channel couples cell metabolism to excitability. To explore role of KATP channels in cellular photobiomodulation, we designed experiment to study effect of low intensity 808 nm laser irradiation on
Fu-qing Zhong, Yang Li, Xian-qiang Mi
doaj +2 more sources
Behavioral phenotyping of mice lacking the KATP channel subunit Kir6.2
Physiology & Behavior, 2006 ATP-sensitive potassium (K(ATP)) channels are expressed in various tissues and cell-types where they act as so-called metabolic sensors that couple metabolic state to cellular excitability. The pore of most K(ATP) channel types is built by Kir6.2 subunits. Analysis of a general Kir6.2 knockout (KO) mouse has identified a variety of different functional
Deacon, R +7 more
openaire +4 more sources
ATP-Sensitive Potassium Channel-Deficient Mice Show Hyperphagia but Are Resistant to Obesity [PDF]
Diabetes & Metabolism Journal, 2011 BackgroundThe hypothalamus, the center for body weight regulation, can sense changes in blood glucose level based on ATP-sensitive potassium (KATP) channels in the hypothalamic neurons.
Yeul Bum Park +7 more
doaj +1 more source