Results 21 to 30 of about 811,037 (204)
Virology Journal, 2023 Declines in managed honey bee populations are multifactorial but closely associated with reduced virus immunocompetence and thus, mechanisms to enhance immune function are likely to reduce viral infection rates and increase colony viability.
Christopher J. Fellows +3 more
doaj +1 more source
Octameric Stoichiometry of the KATP Channel Complex [PDF]
The Journal of General Physiology, 1997 ATP-sensitive potassium (KATP) channels link cellular metabolism to electrical activity in nerve, muscle, and endocrine tissues. They are formed as a functional complex of two unrelated subunits—a member of the Kir inward rectifier potassium channel family, and a sulfonylurea receptor (SUR), a member of the ATP-binding cassette transporter family ...
S, Shyng, C G, Nichols
openaire +2 more sources
Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides
Nature Communications, 2022 KATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic KATP in both the closed state and the pre-open state. These structures illuminate the mechanism of KATP channel regulation by the intracellular nucleotides.
Mengmeng Wang +3 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh +2 more
doaj +1 more source
The therapeutic agents that target ATP-sensitive potassium channels
Acta Pharmaceutica, 2016 ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Rubaiy Hussein N.
doaj +1 more source
Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury. [PDF]
PLoS ONE, 2016 The search for new approaches to treatment and prevention of heart failure is a major challenge in medicine. The adenosine triphosphate-sensitive potassium (KATP) channel has been long associated with the ability to preserve myocardial function and ...
Zhan Gao +8 more
doaj +1 more source
K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect [PDF]
, 2002 Background— Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.
Hubank, M +27 more
core +1 more source
Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc
eLife, 2020 We investigated targeting mechanisms of Na+ and KATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density.
Hua-Qian Yang +7 more
doaj +1 more source
Possible New Strategies for the Treatment of Congenital Hyperinsulinism
Frontiers in Endocrinology, 2020 ObjectiveCongenital hyperinsulinism (CHI) is a rare disease characterized by persistent hypoglycemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants.
Jelena Sikimic +10 more
doaj +1 more source
Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS
EMBO Molecular Medicine, 2023 ABCC9‐related intellectual disability and myopathy syndrome (AIMS) arises from loss‐of‐function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP‐sensitive potassium (KATP) channels.
Conor McClenaghan +7 more
doaj +1 more source