Octameric Stoichiometry of the KATP Channel Complex [PDF]
The Journal of General Physiology, 1997 ATP-sensitive potassium (KATP) channels link cellular metabolism to electrical activity in nerve, muscle, and endocrine tissues. They are formed as a functional complex of two unrelated subunits—a member of the Kir inward rectifier potassium channel family, and a sulfonylurea receptor (SUR), a member of the ATP-binding cassette transporter family ...
S, Shyng, C G, Nichols
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Frontiers in Endocrinology, 2023 Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy/childhood and is a serious condition associated with severe recurrent attacks of hypoglycemia due to dysregulated insulin secretion.
Assmaa ElSheikh +2 more
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Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen [PDF]
, 2014 The effects of hypoxia on gene expression have been vigorously studied, but possible effects of small changes in oxygen tension have never been addressed.
Sukhodub, Andriy +9 more
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Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides
Nature Communications, 2022 KATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic KATP in both the closed state and the pre-open state. These structures illuminate the mechanism of KATP channel regulation by the intracellular nucleotides.
Mengmeng Wang +3 more
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The therapeutic agents that target ATP-sensitive potassium channels
Acta Pharmaceutica, 2016 ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Rubaiy Hussein N.
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Do KATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? [PDF]
, 2000 The objective was to investigate whether myocardial adenosine triphosphate-sensitive K<sup>+</sup> (K<sub>ATP</sub>) channels open during the first 10 min of regional ischaemia in Langendorff-perfused rat hearts.
Northover, B.J. +2 more
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Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury. [PDF]
PLoS ONE, 2016 The search for new approaches to treatment and prevention of heart failure is a major challenge in medicine. The adenosine triphosphate-sensitive potassium (KATP) channel has been long associated with the ability to preserve myocardial function and ...
Zhan Gao +8 more
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Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc
eLife, 2020 We investigated targeting mechanisms of Na+ and KATP channels to the intercalated disk (ICD) of cardiomyocytes. Patch clamp and surface biotinylation data show reciprocal downregulation of each other’s surface density.
Hua-Qian Yang +7 more
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Possible New Strategies for the Treatment of Congenital Hyperinsulinism
Frontiers in Endocrinology, 2020 ObjectiveCongenital hyperinsulinism (CHI) is a rare disease characterized by persistent hypoglycemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants.
Jelena Sikimic +10 more
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ATP-gated potassium channels contribute to ketogenic diet-mediated analgesia in mice
Neurobiology of Pain, 2023 Chronic pain is a substantial health burden and options for treating chronic pain remain minimally effective. Ketogenic diets are emerging as well-tolerated, effective therapeutic strategies in preclinical models of chronic pain, especially diabetic ...
Jonathan D. Enders +7 more
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