Results 31 to 40 of about 811,037 (204)

ATP-gated potassium channels contribute to ketogenic diet-mediated analgesia in mice

Neurobiology of Pain, 2023
Chronic pain is a substantial health burden and options for treating chronic pain remain minimally effective. Ketogenic diets are emerging as well-tolerated, effective therapeutic strategies in preclinical models of chronic pain, especially diabetic ...
Jonathan D. Enders, Sarah Thomas, Paige Lynch, Jarrid Jack, Janelle M. Ryals, Patrycja Puchalska, Peter Crawford, Douglas E. Wright   +7 more
doaj   +1 more source

KATP channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons

Frontiers in Cellular Neuroscience, 2014
Medial temporal lobe structures are essential for memory formation which is associated with coherent network oscillations. During ontogenesis, these highly organized patterns develop from distinct, less synchronized forms of network activity.
Maria S. Lemak, Maria S. Lemak, Oksana eVoloshanenko, Andreas eDraguhn, Andreas eDraguhn, Alexei V. Egorov, Alexei V. Egorov   +6 more
doaj   +1 more source

Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells. [PDF]

PLoS ONE, 2014
ATP-sensitive K+ (KATP) channels play a regulatory role in hormone-secreting pancreatic islet α-, β- and δ-cells. Targeted channel deletion would assist analysis and dissection of the intraislet regulatory network.
Yumiko Nakamura, Joseph Bryan
doaj   +1 more source

Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen [PDF]

, 2014
The effects of hypoxia on gene expression have been vigorously studied, but possible effects of small changes in oxygen tension have never been addressed.
Sukhodub, Andriy, Mohammed Abdul, Khaja Shameem, Du, Qingyou, Jovanovic, Aleksandar, Khaja Shameem Mohammed Abdul, Sofija Jovanović, Jovanovic, Sofija, Aleksandar Jovanović, Andriy Sukhodub, Qingyou Du   +9 more
core   +1 more source

β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel

eLife, 2022
Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-stimulated KATP channel closure and insulin secretion. To identify the PK isoforms involved, we generated mice lacking β-cell PKm1, PKm2, and mitochondrial PEP ...
Hannah R Foster, Thuong Ho, Evgeniy Potapenko, Sophia M Sdao, Shih Ming Huang, Sophie L Lewandowski, Halena R VanDeusen, Shawn M Davidson, Rebecca L Cardone, Marc Prentki, Richard G Kibbey, Matthew J Merrins   +11 more
doaj   +1 more source

The Selective Rat Toxicant Norbormide Blocks KATP Channels in Smooth Muscle Cells But Not in Insulin-Secreting Cells

Frontiers in Pharmacology, 2019
Norbormide is a toxicant selective for rats to which it induces a widespread vasoconstriction. In a recent paper, we hypothesized a role of ATP-sensitive potassium (KATP) channels in norbormide-induced vasoconstriction.
Simona Saponara, Fabio Fusi, Ottavia Spiga, Alfonso Trezza, Brian Hopkins, Brian Hopkins, Margaret A. Brimble, David Rennison, Sergio Bova   +8 more
doaj   +1 more source

Systemic Glucose Homeostasis Requires Pancreatic but Not Neuronal ATP-sensitive Potassium Channels

Function
The adenosine triphosphate (ATP)-sensitive potassium (KATP) channels, composed of Kir6.2 and sulfonylurea receptor 1 (SUR1) subunits, are essential for glucose homeostasis.
Athena H Li, Wen-Sheng Tsai, Wen-Hao Tsai, Shi-Bing Yang   +3 more
doaj   +1 more source

Ketones prevent oxidative impairment of hippocampal synaptic integrity through KATP channels.

PLoS ONE, 2015
Dietary and metabolic therapies are increasingly being considered for a variety of neurological disorders, based in part on growing evidence for the neuroprotective properties of the ketogenic diet (KD) and ketones.
Do Young Kim, Mohammed G Abdelwahab, Soo Han Lee, Derek O'Neill, Roger J Thompson, Henry J Duff, Patrick G Sullivan, Jong M Rho   +7 more
doaj   +1 more source

Do K_ATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart? [PDF]

, 2000
The objective was to investigate whether myocardial adenosine triphosphate-sensitive K⁺ (K_ATP) channels open during the first 10 min of regional ischaemia in Langendorff-perfused rat hearts.
Northover, B.J., MacKenzie, I., Workman, A.J.   +2 more
core   +1 more source

AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

eLife
Pancreatic KATP channel trafficking defects underlie congenital hyperinsulinism (CHI) cases unresponsive to the KATP channel opener diazoxide, the mainstay medical therapy for CHI. Current clinically used KATP channel inhibitors have been shown to act as
Assmaa Elsheikh, Camden M Driggers, Ha H Truong, Zhongying Yang, John Allen, Niel M Henriksen, Katarzyna Walczewska-Szewc, Show-Ling Shyng   +7 more
doaj   +1 more source