Results 11 to 20 of about 14,064 (215)
BAD and KATP channels regulate neuron excitability and epileptiform activity [PDF]
eLife, 2018 Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures ...
Juan Ramón Martínez-François +6 more
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Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells [PDF]
International Journal of Photoenergy, 2014 Background and Objective. ATP-sensitive potassium (KATP) channel couples cell metabolism to excitability. To explore role of KATP channels in cellular photobiomodulation, we designed experiment to study effect of low intensity 808 nm laser irradiation on
Fu-qing Zhong, Yang Li, Xian-qiang Mi
doaj +2 more sources
The Pharmacology of ATP-Sensitive K+ Channels (KATP)
, 2021 ATP-sensitive K+ channels (KATP) are inwardly-rectifying potassium channels, broadly expressed throughout the body. KATP is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels thus playing an important physiological role by coupling cellular metabolism with membrane excitability.
Li, Y, Aziz, Q, Tinker, A
openaire +4 more sources
Ketones prevent oxidative impairment of hippocampal synaptic integrity through KATP channels.
PLoS ONE, 2015 Dietary and metabolic therapies are increasingly being considered for a variety of neurological disorders, based in part on growing evidence for the neuroprotective properties of the ketogenic diet (KD) and ketones.
Do Young Kim +7 more
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American Journal of Physiology-Heart and Circulatory Physiology, 1997 Results from numerous studies have shown that there is an important link between adenosine A1 receptors and ATP-sensitive potassium (KATP) channels in mediating the cardioprotective effects of ischemic preconditioning (PC). The major aim of the present study was to determine whether occupation of A1 receptors and/or the opening of KATP channels is ...
Z, Yao +3 more
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Do KATP channels have a role in immunity? [PDF]
Front ImmunolIon channels, exchangers and pumps are expressed ubiquitously in cells from all phyla of life. In mammals, their role is best described in excitable cells, where they regulate the initiation and propagation of action potentials.
Feske S, Colucci F, Coetzee WA.
europepmc +4 more sources
Role of KATP channels in sepsis [PDF]
Cardiovascular Research, 2006 Sepsis is an infection-induced inflammatory syndrome responsible for approximately 10% of all deaths worldwide. While pathophysiological mechanisms remain to be fully unravelled, new insights and discoveries are yielding significant improvements in outcome, particularly in the high mortality conditions of shock and multi-organ failure.
James F, Buckley +2 more
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Intellectual disability in KATP channel neonatal diabetes [PDF]
Yearbook of Paediatric Endocrinology, 2020 OBJECTIVE Neonatal diabetes has been shown to be associated with high neuropsychiatric morbidity in a genotype-phenotype–dependent manner. However, the specific impact of different mutations on intellectual functioning is still insufficiently characterized.
Pernille Svalastoga +9 more
openaire +2 more sources
Binding of sulphonylureas to plasma proteins - A KATP channel perspective. [PDF]
PLoS ONE, 2018 Sulphonylurea drugs stimulate insulin secretion from pancreatic β-cells primarily by inhibiting ATP sensitive potassium (KATP) channels in the β-cell membrane. The effective sulphonylurea concentration at its site of action is significantly attenuated by
Peter Proks +3 more
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Virology Journal, 2023 Declines in managed honey bee populations are multifactorial but closely associated with reduced virus immunocompetence and thus, mechanisms to enhance immune function are likely to reduce viral infection rates and increase colony viability.
Christopher J. Fellows +3 more
doaj +1 more source