Results 11 to 20 of about 811,037 (204)

BAD and KATP channels regulate neuron excitability and epileptiform activity [PDF]

eLife, 2018
Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures ...
Juan Ramón Martínez-François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica L Burnham, Nika N Danial, Gary Yellen   +6 more
doaj   +2 more sources

Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells [PDF]

International Journal of Photoenergy, 2014
Background and Objective. ATP-sensitive potassium (KATP) channel couples cell metabolism to excitability. To explore role of KATP channels in cellular photobiomodulation, we designed experiment to study effect of low intensity 808 nm laser irradiation on
Fu-qing Zhong, Yang Li, Xian-qiang Mi
doaj   +2 more sources

Membrane trafficking of ATP-sensitive potassium channels [PDF]

, 2005
ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is ...
Smith, Andrew James
core   +9 more sources

The Pharmacology of ATP-Sensitive K+ Channels (KATP)

, 2021
ATP-sensitive K+ channels (KATP) are inwardly-rectifying potassium channels, broadly expressed throughout the body. KATP is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels thus playing an important physiological role by coupling cellular metabolism with membrane excitability.
Li, Y, Aziz, Q, Tinker, A
openaire   +4 more sources

KATP channels and memory of ischemic preconditioning in dogs: synergism between adenosine and KATP channels

American Journal of Physiology-Heart and Circulatory Physiology, 1997
Results from numerous studies have shown that there is an important link between adenosine A1 receptors and ATP-sensitive potassium (KATP) channels in mediating the cardioprotective effects of ischemic preconditioning (PC). The major aim of the present study was to determine whether occupation of A1 receptors and/or the opening of KATP channels is ...
Z, Yao, T, Mizumura, D A, Mei, G J, Gross   +3 more
openaire   +3 more sources

Do K_ATP channels have a role in immunity? [PDF]

Front Immunol
Ion channels, exchangers and pumps are expressed ubiquitously in cells from all phyla of life. In mammals, their role is best described in excitable cells, where they regulate the initiation and propagation of action potentials.
Feske S, Colucci F, Coetzee WA.
europepmc   +7 more sources

Role of KATP channels in sepsis [PDF]

Cardiovascular Research, 2006
Sepsis is an infection-induced inflammatory syndrome responsible for approximately 10% of all deaths worldwide. While pathophysiological mechanisms remain to be fully unravelled, new insights and discoveries are yielding significant improvements in outcome, particularly in the high mortality conditions of shock and multi-organ failure.
James F, Buckley, Mervyn, Singer, Lucie H, Clapp   +2 more
openaire   +2 more sources

Binding of sulphonylureas to plasma proteins - A KATP channel perspective. [PDF]

PLoS ONE, 2018
Sulphonylurea drugs stimulate insulin secretion from pancreatic β-cells primarily by inhibiting ATP sensitive potassium (KATP) channels in the β-cell membrane. The effective sulphonylurea concentration at its site of action is significantly attenuated by
Peter Proks, Holger Kramer, Elizabeth Haythorne, Frances M Ashcroft   +3 more
doaj   +1 more source

Intellectual disability in KATP channel neonatal diabetes [PDF]

Yearbook of Paediatric Endocrinology, 2020
OBJECTIVE Neonatal diabetes has been shown to be associated with high neuropsychiatric morbidity in a genotype-phenotype–dependent manner. However, the specific impact of different mutations on intellectual functioning is still insufficiently characterized.
Pernille Svalastoga, Åsta Sulen, Jarle R. Fehn, Stein M. Aukland, Henrik Irgens, Eivind Sirnes, Silje K.E. Fevang, Eivind Valen, Irene B. Elgen, Pål R. Njølstad   +9 more
openaire   +2 more sources

Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]

, 2005
BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M, Alison Morrissey, Tomoe Y Nakamura, Yoshida, H, Parachuru, L, Nakamura, TY, Coetzee, WA, Lavanya Parachuru, Hidetada Yoshida, Andrew Tinker, Lanning, J, Gwendolyn Lopez, Morrissey, A, Michael Artman, William A Coetzee, Lopez, G, Tong, X, Dhar Chowdhury, P, XiaoYong Tong, Han, S, Jonathan P Giblin, Sandra Han, Giblin, JP, Erika Rosner, Jennifer Lanning, Piyali Dhar Chowdhury, Tinker, A, Rosner, E   +27 more
core   +1 more source