Results 51 to 60 of about 811,037 (204)

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Role of KATP channels in angiogenesis [PDF]

, 2021
Σε πολλά εργαστήρια, σε παγκόσμιο επίπεδο, συντελείται σημαντική ερευνητική προσπάθεια για την ταυτοποίηση νέων μοριακών μηχανισμών στο πεδίο της αγγειογένεσης ως στόχων ανάπτυξης φαρμάκων, καθώς η θεραπευτική ρύθμιση της αγγειογένεσης μπορεί να επηρεάσει σημαντικά την εξέλιξη πολλών ασθενειών.
openaire   +1 more source

Central KATP channels modulate glucose effectiveness in humans and rodents

, 2020
Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this ‘glucose effectiveness’ is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D).
Derek M. Huffman (8614675), Ada Admin (8524211), Eric Lontchi-Yimagou (3919616), William Mitchell (632987), Sylvia Kehlenbrink (8614654), Sudha Koppaka (8614657), Meredith Hawkins (4223689), Sandra Aleksic (8614663), Kehao Zhang (1511314), Sylvan Roger Maginley (8614660), Sarah Reda (8614653), Shobhit Bhansali (4223677), Michelle Carey (836557)   +12 more
core   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Glucose Recruits KATP Channels via Non-Insulin-Containing Dense-Core Granules [PDF]

, 2007
Summaryβ cells rely on adenosine triphosphate-sensitive potassium (KATP) channels to initiate and end glucose-stimulated insulin secretion through changes in membrane potential.
Juntti-Berggren, Lisa, Berggren, Per-Olof, Qiu, Hua, Köhler, Martin, Yang, Guang, Yang, Shao-Nian, Wenna, Nancy Dekki, Yu, Lina, Yu, Jia   +8 more
core   +1 more source

Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs [PDF]

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
Perciaccante, J. V., Domoki, Ferenc, Bari, Ferenc, Veltkamp, R.   +3 more
core   +2 more sources

CL-705G: a novel chemical Kir6.2-specific KATP channel opener

Frontiers in Pharmacology, 2023
Background: KATP channels have diverse roles, including regulation of insulin secretion and blood flow, and protection against biological stress responses and are excellent therapeutic targets.
Ivan Gando, Manuel Becerra Flores, I.-Shan Chen, Hua-Qian Yang, Tomoe Y. Nakamura, Timothy J. Cardozo, William A. Coetzee   +6 more
doaj   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, Volume 13, Issue 54, 28 September 2026.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Evidence for functional ATP-sensitive (KATP) potassium channels in human and equine articular chondrocytes [PDF]

, 2007
SummaryObjectiveChondrocytes are highly sensitive to variations in extracellular glucose and oxygen levels in the extracellular matrix. As such, they must possess a number of mechanisms to detect and respond to alterations in the metabolic state of ...
Womack, M.D, R. Barrett-Jolley, M.D. Womack, Barrett-Jolley, R., Mobasheri, A, Mobasheri, A., C.A. Moskaluk, Nash, A.I, Nash, AI, Gent, T.C., Moskaluk, CA, Moskaluk, C.A., T.C. Gent, Gent, TC, A. Mobasheri, Womack, M.D., A.I. Nash, Gent, T.C, Moskaluk, C.A, Womack, MD, Nash, A.I., Barrett-Jolley, R   +21 more
core   +1 more source