Results 71 to 80 of about 811,037 (204)
, 2022 Aim/Objective: This study aimed to investigate the effects of Rosa damascena Miller essential oil on rat tracheal smooth muscle contractility and the hypothesis that voltage-gated potassium (KV) channels, ATP-sensitive potassium (KATP) channels, and ...
Demirel, Sadettin
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Health Science Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation,
Nawfal Hasan Siam +8 more
wiley +1 more source
Regulation of KATP channel activity
, 2021 ATP-sensitive potassium (KATP) channels are present in many tissues, most notably pancreatic islets and cardiac cells, where they couple the metabolic state of a cell to its electrical activity by regulating the flow of K+ across the membrane in response to the intracellular ATP/ADP ratio.
openaire +1 more source
Molecular Metabolism, 2020 Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown.
Karolina E. Zaborska +10 more
doaj +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.NHE1 inhibition via HOE‐642 suppresses autophagy through the ROS‐AKT/ERK axis, reversing temozolomide resistance in glioblastoma by disrupting the autophagy‐apoptosis balance and enhancing TMZ sensitivity in vitro and in vivo. ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with temozolomide (TMZ) resistance being a ...
Dan Li +10 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 9, September 2026.ABSTRACT MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β‐cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β‐cell compensation and progressive secretory dysfunction.
Lena Eliasson +3 more
wiley +1 more source
International Journal of Cell Biology, 2011 ATP-sensitive potassium channels (KATP) protect the myocardium from hypertrophy induced by pressure-overloading. In this study, we determined the effects of these channels in volume-overloading.
Zikiar V. Alvin +3 more
doaj +1 more source
Annals of the New York Academy of Sciences, Volume 1563, Issue 1, September 2026.Glucagon, a counterregulatory hormone released from pancreatic α‐cells, maintains glucose homeostasis by acting as a protective barrier against hypoglycemia and an amplifier of insulin release when glucose levels rise with feeding. In the body, glucagon secretion is regulated by circulating glucose levels, with elevations in amino acids and via other ...
Samaneh Fatehi +2 more
wiley +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines. [PDF]
, 2007 ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
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