Results 71 to 80 of about 14,064 (215)

Glucose Recruits KATP Channels via Non-Insulin-Containing Dense-Core Granules

, 2007
Summaryβ cells rely on adenosine triphosphate-sensitive potassium (KATP) channels to initiate and end glucose-stimulated insulin secretion through changes in membrane potential.
Juntti-Berggren, Lisa, Berggren, Per-Olof, Qiu, Hua, Köhler, Martin, Yang, Guang, Yang, Shao-Nian, Wenna, Nancy Dekki, Yu, Lina, Yu, Jia   +8 more
core   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Evidence for functional ATP-sensitive (KATP) potassium channels in human and equine articular chondrocytes

, 2007
SummaryObjectiveChondrocytes are highly sensitive to variations in extracellular glucose and oxygen levels in the extracellular matrix. As such, they must possess a number of mechanisms to detect and respond to alterations in the metabolic state of ...
Womack, M.D, R. Barrett-Jolley, M.D. Womack, Barrett-Jolley, R., Mobasheri, A, Mobasheri, A., C.A. Moskaluk, Nash, A.I, Nash, AI, Gent, T.C., Moskaluk, CA, Moskaluk, C.A., T.C. Gent, Gent, TC, A. Mobasheri, Womack, M.D., A.I. Nash, Gent, T.C, Moskaluk, C.A, Womack, MD, Nash, A.I., Barrett-Jolley, R   +21 more
core   +1 more source

Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry

Molecular Metabolism, 2020
Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown.
Karolina E. Zaborska, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Ariel S. Thorson, Charles M. Schaub, Sarah M. Graff, Jade E. Stanley, Roy S. Kondapavuluru, Jerod S. Denton, David A. Jacobson   +10 more
doaj   +1 more source

Integrative Modular, Network‐Based, and Machine Learning Framework for Predicting Accessory Genome Functions and Virulence in Escherichia coli O157:H7

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
An analysis of the accessory genomes from 77 Escherichia coli O157:H7 strains using network and machine learning techniques uncovers modular communities of plasmid‐related virulence associated with IncF replicons. Accessory markers that are not directly linked to toxin genes can effectively predict the virulence status with an AUC of 0.85, facilitating
Sydney Menzeko Gambushe, Oliver Tendayi Zishiri   +1 more
wiley   +1 more source

Metabolic Seizure Resistance via BAD and KATP Channels

, 2016
On a ketogenic diet, ketone bodies provide an alternative fuel, replacing much of the glucose used ordinarily by the brain. This switch is thought to underlie its anticonvulsant effects.
Gary Yellen, Nika N. Danial, Juan Ramón Martínez-François   +2 more
core   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats

International Journal of Cell Biology, 2011
ATP-sensitive potassium channels (KATP) protect the myocardium from hypertrophy induced by pressure-overloading. In this study, we determined the effects of these channels in volume-overloading.
Zikiar V. Alvin, Richard M. Millis, Wissam Hajj-Mousssa, Georges E. Haddad   +3 more
doaj   +1 more source

Five‐year follow‐up of incretin‐based therapy in a patient with KCNJ11‐related permanent neonatal diabetes: Achieving insulin discontinuation and sulfonylurea reduction

Journal of Diabetes Investigation, Volume 17, Issue 6, Page 1075-1078, June 2026.
In a woman with KCNJ11‐related permanent neonatal diabetes mellitus, incretin‐based therapy enabled insulin discontinuation and maintained glycemic control for more than 5 years, with HbA1c between 6.1% and 6.5% on the lowest semaglutide dose, dose‐dependent improvement in insulin secretion, and an approximately 60% reduction in glibenclamide dose ...
Toshiaki Ohkuma, Ryoichiro Aotani, Wakako Sakamoto, Ayaka Oshiro, Tetsuro Ago   +4 more
wiley   +1 more source

Infarct size limitation by nicorandil Roles of mitochondrial KATP channels, sarcolemmal KATP channels, and protein kinase C

, 2002
ObjectivesThis study aimed to examine: 1) whether nicorandil protects the ischemic myocardium by activating sarcolemmal adenosine triphosphate (ATP)-sensitive K+ (sarcKATP) channels or the mitochondrial KATP (mitoKATP) channels, and 2) whether protein ...
Ichikawa, Yoshihiko, Tsuchida, Akihito, Ohnuma, Yoshito, Shimamoto, Kazuaki, Miki, Takayuki, Tanno, Masaya, Kuno, Atsushi, Miura, Tetsuji, Sakamoto, Jun, Matsumoto, Tomoaki   +9 more
core   +1 more source