Results 91 to 100 of about 811,037 (204)

Dynamic duo: Kir6 and SUR in KATP channel structure and function

Channels
KATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium channel ...
Bruce L. Patton, Phillip Zhu, Assmaa ElSheikh, Camden M. Driggers, Show-Ling Shyng   +4 more
doaj   +1 more source

Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels

Frontiers in Physiology, 2013
ATP-sensitive potassium (KATP) channels link cell metabolism to membrane excitability and are involved in a wide range of physiological processes including hormone secretion, control of vascular tone, and protection of cardiac and neuronal cells against ...
Gregory M. Martin, Pei-Chun eChen, Prasanna eDevaraneni, Show-Ling eShyng   +3 more
doaj   +1 more source

Myocardial Protection and the KATP Channel [PDF]

, 1995
1: The biology of KATP channels N.B. Standon. 2: Vascular pathology and the KATP channel U. Quast, S. Glocker. 3: Activation of the ATP-sensitive potassium channels: A novel pharmacological approach to myocardial protection? D.J. Hearse. 4: The relationship between the KATP channel and Myocardial preconditioning G.J. Gross, D.M. Yellon.
openaire   +1 more source

Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome

JCI Insight, 2020
Cantú syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we ...
Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols   +10 more
doaj   +1 more source

Effects of thiol-modifying agents on KATP channels in guinea pig ventricular cells

, 1995
ATP-sensitive K+ (KATP) channels are thought only to open during conditions of metabolic impairment (e.g., myocardial ischemia). However, the regulation of KATP channel opening during ischemia remains poorly understood.
W. A. Coetzee, T. Y. Nakamura, J. F. Faivre   +2 more
core   +1 more source

Probing drug-binding to NBD1 of SUR2A, the regulatory subunit in cardiac KATP channels [PDF]

, 2017
The sulfonylurea receptor 2A (SUR2A) forms the regulatory subunit in ATP-sensitive potassium (KATP) channels in the heart. KATP channels open upon MgATP binding and hydrolysis at the SUR2A nucleotide-binding domains (NBDs).
Park, Miriam Jungeun
core   +2 more sources

PIP2 and PIP as determinants for ATP inhibition of KATP channels.

, 1998
Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels couple electrical activity to cellular metabolism through their inhibition by intracellular ATP.
Tucker, Stephen, Oliver, D, Tucker, SJ, Krauter, T, Schulte, U, Fakler, B, Herlitze, S, Ruppersberg, JP, Baukrowitz, T   +8 more
core   +1 more source

Migraine is a dysfunction of neuronal potassium ion channels

Frontiers in Neurology
Migraine is a primary headache disorder characterized by unilateral pain usually with aura, that affects approximately one in six individuals in India.
Girishwaran M., S. Sajitha Lulu
doaj   +1 more source

Metabolically-sensitive (KATP) channels in enteric neurons

, 2007
Metabolically-sensitive (KATP) channels in enteric ...
Hayato Matsuyama (19187950), Trung V Nguyen (19187959), Karina Needham (593727), Louise Pontell (19187956), John Furness (13070439), Billie Hunne (18608647), Kan Tan (2804611), Kulmira Nurgali (799081)   +7 more
core  

Leptin increases KATP channels’ surface expression of GT1-7 cells to regulate low glucose response

Egyptian Journal of Neurosurgery
Glucose-sensing neurons in the hypothalamus play a pivotal role in maintaining glucose homeostasis in vivo and in detecting hypoglycemia. Leptin, a key hormone regulating body weight and energy balance, has been shown to modulate these glucose-sensing ...
Yi Wu, Yanyan Zhang, Hui Wang, Huoyan Xu, Fangling Peng   +4 more
doaj   +1 more source