Results 91 to 100 of about 14,064 (215)

Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs

, 1999
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R).
David W. Busija, Perciaccante, J. V., Ferenc Domoki, James V. Perciaccante, Domoki, Ferenc, Bari, Ferenc, Ferenc Bari, Roland Veltkamp, Veltkamp, R.   +8 more
core   +1 more source

Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection

Frontiers in Physiology
IntroductionAdenosine triphosphate (ATP)-sensitive potassium (KATP) channels are octameric structures, comprising a pore-forming homotetramer of Kir6.1 or Kir6.2, with 4 accessory sulphonylurea receptor (SUR) subunits.
Sean Brennan, Samir Makwana, Shen Chen, Lauren R. McGuinness, Moustafa Sweihi, Jacob A. Whitmore, Mahmoud E. Elghayesh, Mahmoud E. Elghayesh, Christopher A. Martin, Noorann Sheikh, Manish Patel, Phoebe Malin, Mark W. Sims, Caroline Dart, Richard D. Rainbow   +14 more
doaj   +1 more source

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

Protein & Cell, 2018
ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level.
Jing-Xiang Wu, Dian Ding, Mengmeng Wang, Yunlu Kang, Xin Zeng, Lei Chen   +5 more
doaj   +1 more source

Mitochondrial KATP Channels: The Facts and the Hypotheses

International Journal of Biochemistry & Physiology, 2022
The discovery of mitochondrial KATP channel (mKATP channel) in 1991 started extensive studies of its biophysical and biochemical properties, as well as cytoprotective mechanisms afforded by mKATP channels opening. However, molecular nature of mKATP channels remained undisclosed for three decades, and several hypotheses were proposed about their ...
openaire   +1 more source

Myocardial Protection and the KATP Channel [PDF]

, 1995
1: The biology of KATP channels N.B. Standon. 2: Vascular pathology and the KATP channel U. Quast, S. Glocker. 3: Activation of the ATP-sensitive potassium channels: A novel pharmacological approach to myocardial protection? D.J. Hearse. 4: The relationship between the KATP channel and Myocardial preconditioning G.J. Gross, D.M. Yellon.
openaire   +1 more source

The distribution and function of the ATP-sensitive potassium channel subunit Kir6.1 in cardiac and skeletal muscle cell lines.

, 2007
ATP-sensitive potassium channels (KAtp) are present in the plasma membrane of a number of tissues but are also present on endomembranes such as the endoplasmic reticulum (ER) and mitochondria.
Ng, K-E.
core  

Metabolically-sensitive (KATP) channels in enteric neurons

, 2007
Metabolically-sensitive (KATP) channels in enteric ...
Hayato Matsuyama (19187950), Trung V Nguyen (19187959), Karina Needham (593727), Louise Pontell (19187956), John Furness (13070439), Billie Hunne (18608647), Kan Tan (2804611), Kulmira Nurgali (799081)   +7 more
core  

The high-affinity sulphonylurea receptor regulates KATP channels in nerve terminals of the rat motor cortex

, 1996
The coexpression of sulphonylurea binding sites and ATP-sensitive K+(KATP) channels was examined in the rat motor cortex, an area of the CNS exhibiting a high density of sulphonylurea binding. These channels were not detected on neuronal cell bodies, but
Lee, Kevin, Dixon, Alistair K., Ashford, M L; id_orcid, Richardson, P J, Rowe, I C, Richardson, Peter J., Rowe, Iain C.M., Ashford, Michael L. J.   +7 more
core   +1 more source

From congenital hyperinsulinism to diabetes mellitus: The role of pancreatic β-cell KATP channels

, 2005
Pancreatic β-cell adenosine triphosphate (ATP)-sensitive potassium (KATP) channels play a pivotal role in linking glucose metabolism to regulated insulin secretion.
Cosgrove, Karen E., Hussain, Khalid
core   +1 more source

Dynamic duo: Kir6 and SUR in KATP channel structure and function

Channels
KATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium channel ...
Bruce L. Patton, Phillip Zhu, Assmaa ElSheikh, Camden M. Driggers, Show-Ling Shyng   +4 more
doaj   +1 more source