Results 101 to 110 of about 811,037 (204)

FUNCTIONAL KIR2 AND KATP CHANNELS IN HUMAN PULMONARY VASCULAR SMOOTH MUSCLE AND ENDOTHELIUM MODULATE ARTERIAL TONE

Open Respiratory Archives
Introduction: The resting membrane potential (VM) of vascular cells is a major determinant of arterial tone, integrating the activity of multiple ionic conductances.
Bianca Barreira, Daniel Morales-Cano, Laura Moreno, Beatriz de Olaiz, Rui Adão, Ángel Cogolludo, Francisco Pérez-Vizcaíno, María Sancho   +7 more
doaj   +1 more source

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

Nature Communications
ATP-sensitive potassium (KATP) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells.
Camden M. Driggers, Yi-Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show-Ling Shyng   +4 more
doaj   +1 more source

A Cantú syndrome mutation produces dual effects on KATP channels by disrupting ankyrin B regulation. [PDF]

J Gen Physiol, 2023
Crespo-García T, Rubio-Alarcón M, Cámara-Checa A, Dago M, Rapún J, Nieto-Marín P, Marín M, Cebrián J, Tamargo J, Delpón E, Caballero R.   +10 more
europepmc   +1 more source

KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture. [PDF]

Diabetes, 2023
Ashcroft FM.
europepmc   +1 more source

[Retracted] Morphine‑induced delayed pre‑conditioning against anoxia/reoxygenation injury in pulmonary artery endothelial cells: The role of mitochondrial KATP channels. [PDF]

Mol Med Rep, 2023
Ding W, Guo Y, Cui X, Zhang B, Li D, Li W.   +5 more
europepmc   +1 more source

The high-affinity sulphonylurea receptor regulates KATP channels in nerve terminals of the rat motor cortex

, 1996
The coexpression of sulphonylurea binding sites and ATP-sensitive K+(KATP) channels was examined in the rat motor cortex, an area of the CNS exhibiting a high density of sulphonylurea binding. These channels were not detected on neuronal cell bodies, but
Lee, Kevin, Dixon, Alistair K., Ashford, M L; id_orcid, Richardson, P J, Rowe, I C, Richardson, Peter J., Rowe, Iain C.M., Ashford, Michael L. J.   +7 more
core   +1 more source

Acute Metabolic Stress Induces Lymphatic Dysfunction Through KATP Channel Activation

Function
Lymphatic dysfunction is an underlying component of multiple metabolic diseases, including diabetes, obesity, and metabolic syndrome. We investigated the roles of KATP channels in lymphatic contractile dysfunction in response to acute metabolic stress ...
Hae Jin Kim, Charles E Norton, Scott D Zawieja, Jorge A Castorena-Gonzalez, Michael J Davis   +4 more
doaj   +1 more source

Phentolamine block of KATP channels is mediated by Kir6.2.

, 1997
The ATP-sensitive K+-channel (KATP channel) plays a key role in insulin secretion from pancreatic beta cells. It is closed both by glucose metabolism and the sulfonylurea drugs that are used in the treatment of noninsulin-dependent diabetes mellitus ...
Proks, P, Ashcroft, FM, Ashcroft, Frances   +2 more
core   +1 more source

Gating Mechanism of KATP Channels [PDF]

The Journal of General Physiology, 2003
Enkvetchakul, Decha, NIchols, Colin G
openaire   +3 more sources

ATP-sensitive potassium channels (Katp) in fish cardiac muscle during anoxia and recovery

, 2001
Cardiac muscle from anoxia tolerant and intolerant fishes was used to investigate the importance of ATP-sensitive potassium channels (KATP) in the control of anaerobic cardiac function.
MacCormack, Tyson
core   +1 more source