Results 101 to 110 of about 14,064 (215)

Phentolamine block of KATP channels is mediated by Kir6.2.

, 1997
The ATP-sensitive K+-channel (KATP channel) plays a key role in insulin secretion from pancreatic beta cells. It is closed both by glucose metabolism and the sulfonylurea drugs that are used in the treatment of noninsulin-dependent diabetes mellitus ...
Proks, P, Ashcroft, FM, Ashcroft, Frances   +2 more
core   +1 more source

Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome

JCI Insight, 2020
Cantú syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we ...
Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols   +10 more
doaj   +1 more source

Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels

Frontiers in Physiology, 2013
ATP-sensitive potassium (KATP) channels link cell metabolism to membrane excitability and are involved in a wide range of physiological processes including hormone secretion, control of vascular tone, and protection of cardiac and neuronal cells against ...
Gregory M. Martin, Pei-Chun eChen, Prasanna eDevaraneni, Show-Ling eShyng   +3 more
doaj   +1 more source

Identification of putative potassium channel homologues in pathogenic protozoa [PDF]

, 2012
K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
Prole, D L, Neil V Marrion, Marrion, NV, David L Prole   +3 more
core   +1 more source

Migraine is a dysfunction of neuronal potassium ion channels

Frontiers in Neurology
Migraine is a primary headache disorder characterized by unilateral pain usually with aura, that affects approximately one in six individuals in India.
Girishwaran M., S. Sajitha Lulu
doaj   +1 more source

Leptin increases KATP channels’ surface expression of GT1-7 cells to regulate low glucose response

Egyptian Journal of Neurosurgery
Glucose-sensing neurons in the hypothalamus play a pivotal role in maintaining glucose homeostasis in vivo and in detecting hypoglycemia. Leptin, a key hormone regulating body weight and energy balance, has been shown to modulate these glucose-sensing ...
Yi Wu, Yanyan Zhang, Hui Wang, Huoyan Xu, Fangling Peng   +4 more
doaj   +1 more source

FUNCTIONAL KIR2 AND KATP CHANNELS IN HUMAN PULMONARY VASCULAR SMOOTH MUSCLE AND ENDOTHELIUM MODULATE ARTERIAL TONE

Open Respiratory Archives
Introduction: The resting membrane potential (VM) of vascular cells is a major determinant of arterial tone, integrating the activity of multiple ionic conductances.
Bianca Barreira, Daniel Morales-Cano, Laura Moreno, Beatriz de Olaiz, Rui Adão, Ángel Cogolludo, Francisco Pérez-Vizcaíno, María Sancho   +7 more
doaj   +1 more source

Femoral Vasodilation to Cromakalim is Blocked by U37883A, a Non-sulphonylurea that Selectively Inhibits KATP Channels

, 1995
The purpose of the present study was to determine the effects of U37883A, a non-sulphonylurea inhibitor of KATP channels, in the femoral vascular bed of the anaesthetized dog.
Ernest Franklin, Ella Choe, Tania Grivas, John Ferrara, Howard Lippton, Lewis Flint, Albert Hyman   +6 more
core   +1 more source

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

Nature Communications
ATP-sensitive potassium (KATP) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells.
Camden M. Driggers, Yi-Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show-Ling Shyng   +4 more
doaj   +1 more source

A Cantú syndrome mutation produces dual effects on KATP channels by disrupting ankyrin B regulation. [PDF]

J Gen Physiol, 2023
Crespo-García T, Rubio-Alarcón M, Cámara-Checa A, Dago M, Rapún J, Nieto-Marín P, Marín M, Cebrián J, Tamargo J, Delpón E, Caballero R.   +10 more
europepmc   +1 more source