Results 81 to 90 of about 811,037 (204)

Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice

Frontiers in Neuroscience, 2019
ATP-sensitive potassium (KATP) channels are found in the nervous system and are downstream targets of opioid receptors. KATP channel activity can effect morphine efficacy and may beneficial for relieving chronic pain in the peripheral and central nervous
Cole Fisher, Kayla Johnson, Travis Okerman, Taylor Jurgenson, Austin Nickell, Erin Salo, Madelyn Moore, Alexis Doucette, James Bjork, Amanda H. Klein   +9 more
doaj   +1 more source

Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader‐Willi syndrome

The Journal of Physiology, Volume 604, Issue 17, Page 7313-7336, 1 September 2026.
Abstract figure legend Prader‐Willi syndrome (PWS) originates from deficiencies in chromosome 15q11‐13 region clustering around a critical region containing multiple‐repeat non‐coding RNA gene Snord116, resulting in metabolic and behavioural abnormalities leading to hyperphagia and obesity.
Volodymyr Rybalchenko, Ryan Butler
wiley   +1 more source

Iptakalim A Vascular Atp-Sensitive Potassium (Katp) Channel Opener Closes Rat Pancreatic β-Cell Katp Channels And Increases Insulin Release

, 2007
Sulfonylureas have been the leading oral antihyperglycemic agents, and they presently continue to be the most popular antidiabetic drugs prescribed for treatment of type 2 diabetes.
Lin, Yu Fung, Chang, Yongchang, Wu, Jie, Misaki, Naoko, Wakui, Makoto, Li, Guo Hui, Suga, Sechiko, Wang, Hai, Liu, Qiang, Mao, Xia   +9 more
core   +1 more source

Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome

Frontiers in Pharmacology, 2020
Cantù syndrome (CS) arises from mutations in ABCC9 and KCNJ8 genes that lead to gain of function (GOF) of ATP-sensitive potassium (KATP) channels containing SUR2A and Kir6.1 subunits, respectively, of KATP channels.
Rosa Scala, Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Giulia Maria Camerino, Francesco Alfredo Zito, Girolamo Ranieri, Conor McClenaghan, Theresa M. Harter, Colin G. Nichols, Domenico Tricarico   +10 more
doaj   +1 more source

Novel Roles of Plasma Membrane KATP Channels in the Heart

, 2015
Plasma membrane ATP-sensitive potassium (KATP) channels are found in many excitable cell types where they couple cellular metabolism and membrane excitability. .
Youssef, Nermeen Hosny Ibrahim
core   +1 more source

Regulation of mitochondrial KATP channel by redox agents

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1999
The ATP-dependent K+ channel (KATP) was purified from the inner mitochondrial membrane and reconstituted into lipid bilayer membranes. KATP activity was inhibited by high concentrations of ATP and ADP, but activated by low concentrations (up to 200 microM) of ADP.
Grigoriev, S.M., Skarga, Yu.Yu., Mironova, G.D., Marinov, B.S.   +3 more
openaire   +2 more sources

Role of Cardiac KATP Channels During Anoxia and Ischemia

, 1997
In isolated heart cells, maintained anoxia causes a transient opening of KATP channels. In the ischemic myocardium, this extra K+ conductance results in a decreased contractility and may be arrhythmogenic.
K Benndorf, H Hirche, C Gebhardt, S Thierfelder, B Doepner   +4 more
core   +1 more source

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

Protein & Cell, 2018
ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level.
Jing-Xiang Wu, Dian Ding, Mengmeng Wang, Yunlu Kang, Xin Zeng, Lei Chen   +5 more
doaj   +1 more source

Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection

Frontiers in Physiology
IntroductionAdenosine triphosphate (ATP)-sensitive potassium (KATP) channels are octameric structures, comprising a pore-forming homotetramer of Kir6.1 or Kir6.2, with 4 accessory sulphonylurea receptor (SUR) subunits.
Sean Brennan, Samir Makwana, Shen Chen, Lauren R. McGuinness, Moustafa Sweihi, Jacob A. Whitmore, Mahmoud E. Elghayesh, Mahmoud E. Elghayesh, Christopher A. Martin, Noorann Sheikh, Manish Patel, Phoebe Malin, Mark W. Sims, Caroline Dart, Richard D. Rainbow   +14 more
doaj   +1 more source

Metabolic Seizure Resistance via BAD and KATP Channels

, 2016
On a ketogenic diet, ketone bodies provide an alternative fuel, replacing much of the glucose used ordinarily by the brain. This switch is thought to underlie its anticonvulsant effects.
Gary Yellen, Nika N. Danial, Juan Ramón Martínez-François   +2 more
core   +1 more source