Results 61 to 70 of about 14,064 (215)

Sitagliptin, Metformin and Glimepiride Fixed‐Dose Combination Compared to Co‐Administration of Metformin and High‐Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Double‐Dummy, Phase 3 Clinical Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6207-6216, July 2026.
ABSTRACT Aims This study assessed the efficacy and safety of a triple fixed‐dose combination (FDC) of sitagliptin, metformin, and glimepiride versus co‐administered metformin and glimepiride in Indian patients with uncontrolled Type 2 diabetes (T2D).
Rakesh Sahay, Ambanna Gowda, Manish Kumar Singh, A. Gopal Rao, Ramesh Duraisamy, Dinesh Gangwani, Jitendra Shukla, Vikas Agarwal, Sandesh Sahebarao Patil, Ambrish C., Satish Babu K. N., Arvind Palawat, Sandip Krishnrao Gofne, Abhay Kumar Sahoo, Pradeep Kumar Rai, Raisa Shaikh, Shruti Saha, Dipak Patil, Pravin Ghadge, Piyush Patel, Lalit Lakhwani, Suyog Mehta, Sadhna Joglekar   +22 more
wiley   +1 more source

Mechanical effects on KATP channel gating in rat ventricular myocytes.

PLoS ONE, 2013
Cardiac KATP channels link metabolism with electrical activity. They are implicated in arrhythmias, secretion of atrial natriuretic peptide and protection of the heart from hypertrophy and failure. These processes may involve mechanosensitivity.
Haixia Huang, Lifang Liang, Ping Liu, Hua Wei, Frederick Sachs, Weizhen Niu, Wei Wang   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Clinical Report and Genetic Analysis of a Patient With Congenital Hyperinsulinism Hyperammonemia Caused by a Novel Missense Mutation in the Structural Domain of the Isoform of the GLUD1 Gene

Clinical Case Reports, Volume 14, Issue 6, June 2026.
This patient was admitted to the hospital 43 h after birth with convulsions and hypoglycemia, presenting as recurrent refractory hypoglycemia that was difficult to control with conventional medication. Whole exome sequencing detected the GLUD1 (NM_005271.3:c.1495G>T, p.Gly499Cys) variant, which was a de novo variant in the patient and was not detected ...
Tingyu Li, Tianyi Liu, Lujuan Li, Yang Liu, Qi Zhang, Xian Cheng, Zhong Li   +6 more
wiley   +1 more source

Iptakalim A Vascular Atp-Sensitive Potassium (Katp) Channel Opener Closes Rat Pancreatic β-Cell Katp Channels And Increases Insulin Release

, 2007
Sulfonylureas have been the leading oral antihyperglycemic agents, and they presently continue to be the most popular antidiabetic drugs prescribed for treatment of type 2 diabetes.
Lin, Yu Fung, Chang, Yongchang, Wu, Jie, Misaki, Naoko, Wakui, Makoto, Li, Guo Hui, Suga, Sechiko, Wang, Hai, Liu, Qiang, Mao, Xia   +9 more
core   +1 more source

Consensus on the Clinical Use of Pregabalin in Peripheral Neuropathic Pain

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Pregabalin, a second‐generation α2δ calcium‐channel ligand, exerts potent analgesic effects in peripheral neuropathic pain by reducing calcium influx, suppressing excitatory neurotransmitter release, and decreasing neuronal hyperexcitability. Based on a PRISMA‐guided review of 139 studies and multidisciplinary expert consensus, pregabalin demonstrates ...
Hui Lu, Yuefeng Rao, Jian Wang, Wan Shuanglin, Du Dongping, Ma Ke, Zhiying Feng, Suming Tian, Weidong Qiu, Xu Jing, Zhongwei zhao, Zhenhua Zeng, Benyan Luo, Changqing Wang, Hui Zhao, Kaiming Liu, Li Lin, Xianfeng Zhang, Gong Liyan, Haiqi Lu, Yan Liu, Qingwei Zhao, Yihe Hu   +22 more
wiley   +1 more source

Single Nucleotide Polymorphisms in KATP Channels [PDF]

Diabetes, 2005
ATP-sensitive K+ channels (KATP channels) play an important role in glucose homeostasis. A single nucleotide polymorphism (SNP) in the Kir6.2 subunit causes a point mutation of Glu23 to lysine and reduces the ATP sensitivity of pancreatic KATP channels. The SNP found in 58% of Caucasians accounts for 15% of type 2 diabetes.
Li Li, Yun Shi, Xueren Wang, Weiwei Shi, Chun Jiang   +4 more
openaire   +1 more source

Role of Cardiac KATP Channels During Anoxia and Ischemia

, 1997
In isolated heart cells, maintained anoxia causes a transient opening of KATP channels. In the ischemic myocardium, this extra K+ conductance results in a decreased contractility and may be arrhythmogenic.
K Benndorf, H Hirche, C Gebhardt, S Thierfelder, B Doepner   +4 more
core   +1 more source

Pancreatic Islet Cell Crosstalk: Insight Into α‐/β‐Cell Compensatory Mechanisms

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
α‐cell remodeling compensates for impaired β‐cell function. Intra‐islet glucagon/GLP‐1 signaling is upregulated and becomes essential in prediabetic islets. Flexible receptor engagement reflects functional plasticity in hormonal control of insulin secretion. Created in BioRender. Plecita, L. (2026); https://BioRender.com/pgjjg3m.
Štěpánka Benáková, Blanka Holendová, Jurij Dolenšek, Monika Křivonosková, Andraž Stožer, Lydie Plecitá‐Hlavatá   +5 more
wiley   +1 more source

Regulation of KATP channel activity

, 2021
ATP-sensitive potassium (KATP) channels are present in many tissues, most notably pancreatic islets and cardiac cells, where they couple the metabolic state of a cell to its electrical activity by regulating the flow of K+ across the membrane in response to the intracellular ATP/ADP ratio.
openaire   +1 more source