Results 41 to 50 of about 1,646 (125)

Bisphosphonates Targeting Ion Channels and Musculoskeletal Effects

Frontiers in Pharmacology, 2022
Bisphosphonates (BPs) are the most used bone-specific anti-resorptive agents, often chosen as first-line therapy in several bone diseases characterized by an imbalance between osteoblast-mediated bone production and osteoclast-mediated bone resorption ...
Rosa Scala, Fatima Maqoud, Marina Antonacci, Jacopo Raffaele Dibenedetto, Maria Grazia Perrone, Antonio Scilimati, Karen Castillo, Karen Castillo, Ramón Latorre, Diana Conte, Saïd Bendahhou, Domenico Tricarico   +11 more
doaj   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Altered mRNA Expression of ATP-Sensitive and Inward Rectifier Potassium Channel Subunits in Streptozotocin-Induced Diabetic Rat Heart and Aorta

Journal of Pharmacological Sciences, 2003
: Cardiovascular diseases are the most frequent and costly complication of diabetes. Many previous studies showed that ATP-sensitive potassium channels (KATP) and inward rectifier potassium channels (Kir) play important regulatory roles in functions of ...
Yajun Ren, Xianghua Xu, Xiaoliang Wang
doaj   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome

JCI Insight, 2020
Cantú syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we ...
Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols   +10 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Harnessing metabolic control for synaptic stability: REST/NRSF links glycolytic inhibition to excitatory neurotransmission

The Journal of Physiology, Volume 603, Issue 22, Page 7207-7233, November 15, 2025.
Abstract figure legend Schematic of REST/NRSF‐dependent postsynaptic downscaling of excitatory strength in response to glycolysis inhibition Glycolysis inhibition enhances REST/NRSF expression and increases REST/NRSF transcriptional repressor activity by promoting its translocation into the nucleus.
Daniele Ferrante, Barbara Parisi, Antonella Marte, Dionisi Marianna, Cosimo Prestigio, Andrea Benzi, Santina Bruzzone, Fabio Benfenati, Franco Onofri, Pierluigi Valente, Pietro Baldelli   +10 more
wiley   +1 more source

Parkinson's disease‐linked Kir4.2 mutation R28C leads to loss of ion channel function

The Journal of Physiology, Volume 603, Issue 12, Page 3499-3518, 15 June 2025.
Abstract figure legend Pathogenic impact of the PD‐linked Kir4.2R28C mutation on Kir4.2 channel proteostasis and function. The Kir4.2R28C mutation, identified in a familial Parkinson's disease (PD) pedigree, leads to a near‐complete loss of potassium channel function and exerts a significant dominant‐negative effect.
Xiaoyi Chen, Rocio K. Finol‐Urdaneta, Mo Chen, Alex M. Sykes, Bingmiao Gao, Jamila Iqbal, David J. Adams, George D. Mellick, Linlin Ma   +8 more
wiley   +1 more source

Blood–Brain Barrier (BBB) Dysfunction in CNS Diseases: Paying Attention to Pericytes

CNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.
This review highlights the critical role of pericytes in BBB dysfunction in central nervous system diseases. It explores their involvement in diseases like Alzheimer's, stroke, and multiple sclerosis, and discusses potential therapeutic strategies, including regenerative medicine and PC‐EVs.
Tianrui Yu, Zixuan Wang, Yanghang Chen, Yuanyuan Xiang, Moxin Wu, Manqing Zhang, Xiaoping Yin, Zhiying Chen   +7 more
wiley   +1 more source

Potassium channel‐mediated NO‐induced vasodilation during maturation: Dominance of Kv7 channels

FASEB BioAdvances, Volume 7, Issue 3, March 2025.
Scheme illustrating the key findings: Potassium channels, even multiple ones, contribute to SNP‐induced vasorelaxation in young and adult rats and these channels change from Kv1 and Kv7 channels to BKCa and Kv7 channels during postnatal development.
Anastasia A. Shvetsova, Dina K. Gaynullina, Peter Winkler, Paulus Wohlfart, Rudolf Schubert   +4 more
wiley   +1 more source