Results 51 to 60 of about 1,646 (125)
Andrology, Volume 13, Issue 2, Page 184-201, February 2025.Abstract Background Ion channels are essential for differentiation and maturation of germ cells, and even for fertilization in mammals. Different types of potassium channels have been identified, which are grouped into voltage‐gated channels (Kv), ligand‐gated channels (Kligand), inwardly rectifying channels (Kir), and tandem pore domain channels (K2P).
Ariadna Delgado‐Bermúdez +3 more
wiley +1 more source
Expression and function of mechanosensitive ion channels in human valve interstitial cells.
PLoS ONE, 2020 BackgroundThe ability of heart valve cells to respond to their mechanical environment represents a key mechanism by which the integrity and function of valve cusps is maintained.
Hessah Al-Shammari +9 more
doaj +1 more source
The Role of Ion Channels in Pulmonary Hypertension: A Review
Pulmonary Circulation, Volume 15, Issue 1, January 2025.ABSTRACT Pulmonary hypertension (PH) constitutes a critical challenge in cardiopulmonary medicine with a pathogenesis that is multifaceted and intricate. Ion channels, crucial determinants of cellular electrochemical gradient modulation, have emerged as significant participants in the pathophysiological progression of PH.
Han‐Fei Li +11 more
wiley +1 more source
PLoS ONE, 2014 Exercise training offers cardioprotection against ischemia and reperfusion (I/R) injury. However, few essential signals have been identified to underscore the protection from injury.
Yuanjing Li +13 more
doaj +1 more source
MedComm, Volume 5, Issue 12, December 2024.This study identified a type of pericyte highly related to BBTB function in GBM, with PTH1R potentially serving as a marker for these pericytes. PTH1R+ pericytes expressed extracellular matrix (ECM) genes to interact with integrins of other GBM cells, and had increased expression of ECM genes such collagen IV and FN1 in GBM.
Yuzhe Li +9 more
wiley +1 more source
KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy
Molecular Pain, 2010 Background ATP-sensitive potassium (KATP) channels in neurons mediate neuroprotection, they regulate membrane excitability, and they control neurotransmitter release.
Gemes Geza +8 more
doaj +1 more source
Role of hydrogen sulfide in health and disease
MedComm, Volume 5, Issue 9, September 2024.Abstract In the past, hydrogen sulfide (H2S) was recognized as a toxic and dangerous gas; in recent years, with increased research, we have discovered that H2S can act as an endogenous regulatory transmitter. In mammals, H2S‐catalyzing enzymes, such as cystathionine‐β‐synthase, cystathionine‐γ‐lyase, and 3‐mercaptopyruvate sulfurtransferase, are ...
Yu‐Qing Jin +9 more
wiley +1 more source
British Journal of Pharmacology, Volume 181, Issue 18, Page 3380-3400, September 2024.Abstract Background and Purpose The canonical Kir6.2/SUR2A ventricular KATP channel is highly ATP‐sensitive and remains closed under normal physiological conditions. These channels activate only when prolonged metabolic compromise causes significant ATP depletion and then shortens the action potential to reduce contractile activity.
Sean Brennan +16 more
wiley +1 more source
British Journal of Pharmacology, Volume 181, Issue 15, Page 2478-2491, August 2024.Abstract Background and Purpose Calcitonin gene‐related peptide (CGRP) is a potent vasodilator. While its signalling is assumed to be mediated via increases in cAMP, this study focused on elucidating the actual intracellular signalling pathways involved in CGRP‐induced relaxation of human isolated coronary arteries (HCA). Experimental Approach HCA were
Tessa de Vries +10 more
wiley +1 more source
Ectopic overexpression of Kir6.1 in the mouse heart impacts on the life expectancy
Scientific Reports, 2018 We recently reported the reduced ATP-sensitive potassium (KATP) channel activities in the transgenic mouse heart overexpressing the vascular type KATP channel pore-forming subunit (Kir6.1).
Yasuhiro Watanabe +5 more
doaj +1 more source