Results 61 to 70 of about 1,646 (125)

The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel

Cell Reports, 2019
Summary: Repaglinide (RPG) is a short-acting insulin secretagogue widely prescribed for the treatment of type 2 diabetes. It boosts insulin secretion by inhibiting the pancreatic ATP-sensitive potassium channel (KATP).
Dian Ding, Mengmeng Wang, Jing-Xiang Wu, Yunlu Kang, Lei Chen   +4 more
doaj   +1 more source

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice

JCI Insight, 2021
Cantu syndrome (CS) is caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunits, the most common mutations being SUR2[R1154Q] and SUR2[R1154W], carried by ...
Haixia Zhang, Alex Hanson, Tobias Scherf de Almeida, Christopher Emfinger, Conor McClenaghan, Theresa Harter, Zihan Yan, Paige E. Cooper, G. Schuyler Brown, Eric C. Arakel, Robert P. Mecham, Atilla Kovacs, Carmen M. Halabi, Blanche Schwappach, Maria S. Remedi, Colin G. Nichols   +15 more
doaj   +1 more source

In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat

Journal of Pharmacological Sciences, 2016
The lower esophageal sphincter (LES) is a specialized region of the esophageal smooth muscle that allows the passage of a swallowed bolus into the stomach. Nitric oxide (NO) plays a major role in LES relaxation.
Tomonori Shimbo, Takeshi Adachi, Susumu Fujisawa, Mai Hongoh, Takayoshi Ohba, Kyoichi Ono   +5 more
doaj   +1 more source

Transgenic overexpression of the SUR2A-55 splice variant in mouse heart reduces infract size and promotes protective mitochondrial function

Heliyon, 2018
ATP-sensitive potassium channels found in both the sarcolemma (sarcKATP) and mitochondria (mitoKATP) of cardiomyocytes are important mediators of cardioprotection during ischemic heart disease.
Mohun Ramratnam, Barrett Kenny, John W. Kyle, Brandi Wiedmeyer, Timothy A. Hacker, David Y. Barefield, Elizabeth M. McNally, Jonathan C. Makielski   +7 more
doaj   +1 more source

Kir6.1基因敲除小鼠脑梗死周围扩散性去极化波的 内源光信号成像

Zhongshan Daxue xuebao. Yixue kexue ban, 2015
【目的】 观测小鼠脑梗死周围扩散性去极化波(PID)的内源光信号变化特征,了解Kir6.1基因敲除对小鼠PID的影响?【方法】 以Kir6.1基因敲除小鼠及同窝野生型小鼠各10只为研究对象,线栓法制备大脑中动脉梗死(MCAO)模型,应用四波长内源光信号(OIS)成像技术监测PID的发作情况,比较两组之间的差异?【结果】 OIS成像显示PID在空间分布上表现为由发源处向四周缓慢播散的?红蓝相间的弧形波,;PID存在4种不同播散类型:喙-尾播散类型?侧方-内侧播散类型?尾-喙播散类型和对侧播散类型;Kir6.
doaj  

ATP sensitive potassium channels in the skeletal muscle functions : involvement of the KCNJ11(Kir6.2) gene in the determination of Warner Bratzer shear force

Frontiers in Physiology, 2016
The ATP-sensitive K+-channels (KATP) are distributed in the tissues coupling metabolism with K+ ions efflux. KATP subunits are encoded by KCNJ8 (Kir6.1), KCNJ11 (Kir6.2), ABCC8 (SUR1) and ABCC9 (SUR2) genes, alternative RNA splicing give rise to SUR ...
Domenico eTricarico, Maria eSelvaggi, Giuseppe ePassantino, Pasquale eDe Palo, Dario eCataldo, Pasquale eCentoducati, Alessandra eTateo, Angela eCurci, Fatima eMaquod, Antonietta eMele, Giulia Maria eCamerino, Antonella eLiantonio, Paola eImbrici, Nicola eZizzo   +13 more
doaj   +1 more source

A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels

Neuroscience Research
Epilepsy is a common neurological disorder worldwide. Hydrogen sulfide (H2S) has been found to have anti-seizure effects. However, its mechanism remains to be explored.
Qiyun Kang, Ziting Zhu, Zhongrui Liu, Fei Li, Yan He, Yaru Yang, Xutao Wang, Shuisheng Lei, Zishu Yuan, Xiaoqin Zhu   +9 more
doaj   +1 more source

FUNCTIONAL KIR2 AND KATP CHANNELS IN HUMAN PULMONARY VASCULAR SMOOTH MUSCLE AND ENDOTHELIUM MODULATE ARTERIAL TONE

Open Respiratory Archives
Introduction: The resting membrane potential (VM) of vascular cells is a major determinant of arterial tone, integrating the activity of multiple ionic conductances.
Bianca Barreira, Daniel Morales-Cano, Laura Moreno, Beatriz de Olaiz, Rui Adão, Ángel Cogolludo, Francisco Pérez-Vizcaíno, María Sancho   +7 more
doaj   +1 more source

Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome

JCI Insight
Cantú syndrome is a multisystem disorder caused by gain-of-function (GOF) mutations in KCNJ8 and ABCC9, the genes encoding the pore-forming inward rectifier Kir6.1 and regulatory sulfonylurea receptor SUR2B subunits, respectively, of vascular ATP ...
Elsayed Metwally, Alfredo Sanchez Solano, Boris Lavanderos, Evan Yamasaki, Pratish Thakore, Conor McClenaghan, Natalia Rios, Rafael Radi, Yumei Feng Earley, Colin G. Nichols, Scott Earley   +10 more
doaj   +1 more source

[Exogenous nitric oxide suppresses K _ATP channel activity through S-nitrosylation]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
Wang X, Zhang Y, Hu W, Hao X.
europepmc   +1 more source