Results 21 to 30 of about 1,646 (125)

From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel [PDF]

PeerJ, 2018
Background ATP-sensitive inward rectifier potassium channels (Kir), are a potassium channel family involved in many physiological processes. KATP dysfunctions are observed in several diseases such as hypoglycaemia, hyperinsulinemia, Prinzmetal angina ...
Alfonso Trezza, Vittoria Cicaloni, Piera Porciatti, Andrea Langella, Fabio Fusi, Simona Saponara, Ottavia Spiga   +6 more
doaj   +2 more sources

Expression of ATP sensitive K+ channel subunit Kir6.1 in rat kidney

European Journal of Histochemistry, 2009
ATP-sensitive K+ (KATP) channels in kidney are considered to play roles in regulating membrane potential during the change in intracellular ATP concentration.
M Zhou, HJ He, R Suzuki, O Tanaka, M Sekiguchi, Y Yasuoka, K Kawahara, H Itoh, H Abe   +8 more
doaj   +1 more source

The expression of ATP-sensitive potassium channels in human umbilical arteries with severe pre-eclampsia

Scientific Reports, 2021
The aim of this study is to establish the expression of ATP-sensitive potassium channels(KATP) in human umbilical arteries with severe pre-eclampsia.
Benlan Yin, Yujiao Zhang, Xiaohong Wei, Chunrong Pang, Ting Hou, Chao Yang, Yuzhi Ning, Xiaodong Fu   +7 more
doaj   +1 more source

Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

Respiratory Research, 2018
Background ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion ...
Maurizio Turzo, Julian Vaith, Felix Lasitschka, Markus A. Weigand, Cornelius J. Busch   +4 more
doaj   +1 more source

Role of potassium channels in female reproductive system [PDF]

Obstetrics & Gynecology Science, 2020
Potassium channels are widely expressed in most types of cells in living organisms and regulate the functions of a variety of organs, including kidneys, neurons, cardiovascular organs, and pancreas among others. However, the functional roles of potassium
Jun-Mo Kim, Ki-Sung Song, Boqun Xu, Tong Wang   +3 more
doaj   +1 more source

and as significant hub genes for vein graft restenosis

Journal of International Medical Research, 2020
Background Vein graft restenosis (VGR), which appears to be caused by dyslipidemia following vascular transplantation, seriously affects the prognosis and long-term quality of life of patients.
Yun-peng Bai, Bo-chen Yao, Mei Wang, Xian-kun Liu, Xiao-long Zhu, Lian-qun Wang, Nan Jiang, Zhi-gang Guo, Qing-liang Chen   +8 more
doaj   +1 more source

The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3

Experimental and Molecular Medicine, 2019
Diabetes: Inflammation in insulin resistance A potassium-regulating molecule, Kir6.1, blocks inflammation and prevents insulin resistance (IR), a hallmark of type 2 diabetes. Insulin triggers cellular glucose absorption, lowering blood glucose levels. In
Ren-Hong Du, Ming Lu, Cong Wang, Jian-Hua Ding, Guangyu Wu, Gang Hu   +5 more
doaj   +1 more source

Effects of corticotropin-releasing hormone on the expression of adenosine triphosphate-sensitive potassium channels (Kir6.1/SUR2B) in human term pregnant myometrium [PDF]

Obstetrics & Gynecology Science, 2018
ObjectiveCorticotropin-releasing hormone (CRH) is a crucial regulator of human pregnancy and parturition. Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels are important for regulating myometrial quiescence during pregnancy.
Joo Young Kim, Wen Hao Wu, Jin Hyun Jun, Jeenah Sohn, Yong Soo Seo   +4 more
doaj   +1 more source

CL-705G: a novel chemical Kir6.2-specific KATP channel opener

Frontiers in Pharmacology, 2023
Background: KATP channels have diverse roles, including regulation of insulin secretion and blood flow, and protection against biological stress responses and are excellent therapeutic targets.
Ivan Gando, Manuel Becerra Flores, I.-Shan Chen, Hua-Qian Yang, Tomoe Y. Nakamura, Timothy J. Cardozo, William A. Coetzee   +6 more
doaj   +1 more source

Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug–disease interactions

Frontiers in Pharmacology, 2023
Background: ATP-sensitive-K+ channels (KATP) are involved in diseases, but their role in cancer is poorly described. Pituitary macroadenoma has been observed in Cantu’ syndrome (C.S.), which is associated with the gain-of-function mutations of the ABCC9 ...
Fatima Maqoud, Fatima Maqoud, Nicola Zizzo, Marcella Attimonelli, Antonella Tinelli, Giuseppe Passantino, Marina Antonacci, Girolamo Ranieri, Domenico Tricarico   +8 more
doaj   +1 more source