Results 11 to 20 of about 1,901 (173)

Characterization of four structurally diverse inhibitors of SUR2-containing KATP channels [PDF]

Channels
Vascular smooth muscle ATP-sensitive potassium (KATP) channels play critical roles in modulating vascular tone and thus represent important drug targets for diverse cardiovascular pathologies.
Kangjun Li, Vaishali Satpute Janve, Jerod Denton   +2 more
doaj   +5 more sources

Consequences of SUR2[A478V] Mutation in Skeletal Muscle of Murine Model of Cantu Syndrome [PDF]

Cells, 2021
(1) Background: Cantu syndrome (CS) arises from gain-of-function (GOF) mutations in the ABCC9 and KCNJ8 genes, which encode ATP-sensitive K+ (KATP) channel subunits SUR2 and Kir6.1, respectively.
Rosa Scala, Fatima Maqoud, Nicola Zizzo, Giuseppe Passantino, Antonietta Mele, Giulia Maria Camerino, Conor McClenaghan, Theresa M. Harter, Colin G. Nichols, Domenico Tricarico   +9 more
doaj   +6 more sources

Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes. [PDF]

PLoS ONE, 2012
Two mammalian genes encode the SURx (SUR1, Abcc8 and SUR2, Abcc9) subunits that combine with Kir6.2 (Kcnj11) subunits to form the ATP-sensitive potassium (KATP) channel in cardiac myocytes.
Naheed Fatima, James F Schooley, Willliam C Claycomb, Thomas P Flagg   +3 more
doaj   +5 more sources

Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome [PDF]

JCI Insight, 2020
Cantú syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we ...
Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols   +10 more
doaj   +6 more sources

Identification of sur2 mutation affecting the lifespan of fission yeast [PDF]

FEMS Microbiology Letters, 2021
ABSTRACT Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronological lifespan and found a missense mutation in the sur2+ gene, which encodes a homolog of Saccharomyces cerevisiae sphingolipid C4 ...
Tatsuhiro Kurauchi, Kotaro Matsui, Takafumi Shimasaki, Hokuto Ohtsuka, Satoshi Tsubouchi, Kunio Ihara, Motohiro Tani, Hirofumi Aiba   +7 more
openaire   +3 more sources

Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrests Growth of Gynecologic Cancers [PDF]

Frontiers in Pharmacology, 2020
Gynecologic cancers are among the most lethal cancers found in women, and, advanced stage cancers are still a treatment challenge. Ion channels are known to contribute to cellular homeostasis in all cells and mounting evidence indicates that ion channels
Daniela Fukushiro-Lopes, Alexandra D. Hegel, Alexandra D. Hegel, Angela Russo, Vitalyi Senyuk, Margaret Liotta, Gyda C. Beeson, Craig C. Beeson, Joanna Burdette, Ronald K. Potkul, Saverio Gentile, Saverio Gentile   +11 more
doaj   +3 more sources

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice. [PDF]

J Gen Physiol
Cantu syndrome (CS) is a rare disease caused by gain-of-function (GOF) mutations of Kir6.1 or SUR2 subunits of ATP-sensitive potassium (KATP) channels. CS patients with SUR2 and Kir6.1 variants display a similar constellation of symptoms, including muscle weakness and fatigue.
Scala R, Mukadam M, Chen Y, Frazier C, York NW, Tryon RC, Meyer GA, Nichols CG.   +7 more
europepmc   +5 more sources

TheSUR2gene ofArabidopsis thalianaencodes the cytochrome P450 CYP83B1, a modulator of auxin homeostasis [PDF]

Proceedings of the National Academy of Sciences, 2000
Genetic screens have been performed to identify mutants with altered auxin homeostasis inArabidopsis. A tagged allele of the auxin-overproducing mutantsur2was identified within a transposon mutagenized population. TheSUR2gene was cloned and shown to encode the CYP83B1 protein, which belongs to the large family of the P450-dependent monooxygenases ...
Barlier, Isabelle, Kowalczyk, Mariusz, Marchant, Alan, Ljung, Karin, Bhalerao, Rishikest, Bennett, Malcolm, Sandberg, Goeran, Bellini, Catherine   +7 more
openaire   +5 more sources

The Mitochondrial Bioenergetic Phenotype for Protection from Ischemia in Sur2-Mutant Mice [PDF]

Biophysical Journal, 2010
ATP-sensitive potassium channels (KATP) in mitochondria are postulated to play a key role to protect mitochondria and myocytes from cardiac ischemic insult. The sulfonylurea receptor-2 (SUR2) is a subunit of KATP in sarcolemma, although its role in mitochondrial physiology is unclear. Mice where the SUR2 gene was disrupted (SUR2 mutant) have been shown
Aggarwal, Nitin, Pravdic, Danijel, Mcnally, Elizabeth M., Bosnjak, Zeljko J., Shi, Nian-Qing, Makielski, Jonathan C.   +5 more
openaire   +2 more sources

Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with KATP channel gain-of-function

Function, 2023
Cantú Syndrome (CS) is an autosomal dominant disorder caused by gain-of-function (GoF) mutations in the Kir6.1 and SUR2 subunits of KATP channels.
Michael J Davis, Jorge A Castorena-Gonzalez, Hae Jin Kim, Min Li, Maria Remedi, Colin G Nichols   +5 more
doaj   +2 more sources