Results 41 to 50 of about 1,901 (173)
Case Report: Loss-of-Function ABCC9 Genetic Variant Associated With Ventricular Fibrillation
Frontiers in Genetics, 2022 Genetic variants in the ABCC9 gene, encoding the SUR2 auxiliary subunit from KATP channels, were previously linked with various inherited diseases. This wide range of congenital disorders includes multisystem and cardiovascular pathologies.
Anastasia Zaytseva +7 more
doaj +1 more source
The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice
American Journal of Physiology-Heart and Circulatory Physiology, 2010 The sulfonylurea receptor-2 (SUR2) is a subunit of ATP-sensitive potassium channels (KATP) in heart. Mice with the SUR2 gene disrupted (SUR2m) are constitutively protected from ischemia-reperfusion (I/R) cardiac injury. This was surprising because KATP, either sarcolemmal or mitochondrial or both, are thought to be important for cardioprotection.
Nitin T, Aggarwal +5 more
openaire +3 more sources
BMC Microbiology, 2001 Background The ability of Mycobacterium tuberculosis to survive and replicate in macrophages is crucial for the mycobacterium's ability to infect the host and cause tuberculosis.
Shinnick Thomas M, Miller Barbara H
doaj +1 more source
Function, 2020 Dramatic cardiomegaly arising from gain-of-function (GoF) mutations in the ATP-sensitive potassium (KATP) channels genes, ABCC9 and KCNJ8, is a characteristic feature of Cantú syndrome (CS).
Conor McClenaghan +10 more
doaj +1 more source
, 2005 BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M +27 more
core +1 more source
KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy
Molecular Pain, 2010 Background ATP-sensitive potassium (KATP) channels in neurons mediate neuroprotection, they regulate membrane excitability, and they control neurotransmitter release.
Gemes Geza +8 more
doaj +1 more source
CSU52, a novel regulator functions as a repressor of L-sorbose utilization in Candida albicans
Iranian Journal of Microbiology, 2021 Background and Objectives: Monosomy of chromosome 5 associated with utilization of non-canonical sugar L-sorbose is one of the well-studied aneuploidies in Candida albicans.
Dileep Pullepu +3 more
doaj +1 more source
ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant [PDF]
Channels, 2013 Cardiac ATP-sensitive potassium channels (KATP) are found in both the sarcoplasmic reticulum (sarcKATP) and the inner membrane of mitochondria (mitoKATP). SarcKATP are composed of a pore containing subunit Kir6.2 and a regulatory sulfonylurea receptor subunit (SUR2), but the composition of mitoKATP remains unclear.
Nitin T, Aggarwal +2 more
openaire +2 more sources
CpG islands in the SUR1 (Abcc8) and SUR2 (Abcc9) genes.
, 2013 Cartoon illustrating the first exon and proximal upstream region of the SUR1 (top) and SUR2 (bottom) genes are shown. Sequence analysis with CpG Island Searcher software [40], reveals CpG islands in both SUR1 and SUR2 genes, that are at least 200 bp in ...
Willliam C. Claycomb (314777) +3 more
core +1 more source
Diazoxide promotes oligodendrocyte precursor cell proliferation and myelination. [PDF]
PLoS ONE, 2010 Several clinical conditions are associated with white matter injury, including periventricular white matter injury (PWMI), which is a form of brain injury sustained by preterm infants.
Birgit Fogal +4 more
doaj +1 more source