Results 61 to 70 of about 1,901 (173)

Chamber-specific SUR1 and SUR2 expression does not correlate with CpG island methylation.

, 2013
Total CpG island methylation of SUR1 and SUR2 as measured using either (A) EpiTect assay or (B) bisulfite sequencing. Using either method, SUR1 and SUR2 CpG islands were predominantly unmethylated in both atrial and ventricular genomic DNA.
Willliam C. Claycomb (314777), Naheed Fatima (314771), Thomas P. Flagg (314778), James F. Schooley Jr (314774)   +3 more
core   +1 more source

Entangled Discourses and Realities of English: Japanese Undergraduates’ Everyday Online and Offline Language Experiences

International Journal of Applied Linguistics, EarlyView.
ABSTRACT Focusing on the narratives of two Japanese undergraduate students, this article examines their everyday experiences of using and learning English, situated within entangled relations of power. Drawing on the Foucauldian notion of discourse, the study reveals how multiple power/knowledge systems—such as native speakerism, prescriptivism ...
Aina Tanaka, Daisuke Kimura
wiley   +1 more source

The synthetic amphipathic peptidomimetic LTX109 is a potent fungicide that disturbs plasma membrane integrity in a sphingolipid dependent manner. [PDF]

PLoS ONE, 2013
The peptidomimetic LTX109 (arginine-tertbutyl tryptophan-arginine-phenylethan) was previously shown to have antibacterial properties. Here, we investigated the activity of this novel antimicrobial peptidomimetic on the yeast Saccharomyces cerevisiae.
Rasmus Bojsen, Rasmus Torbensen, Camilla Eggert Larsen, Anders Folkesson, Birgitte Regenberg   +4 more
doaj   +1 more source

A cytochrome P450 gene, GmSUR2a, confers submergence tolerance and improves yield in soybean by modulating auxin homeostasis

Journal of Integrative Plant Biology, EarlyView.
The key cytochrome P450 gene GmSUR2a enables soybeans to withstand destructive submergence stress. By lowering the level of the plant hormone indole‐3‐acetic acid, this gene improves soybean survival and increases field yield. It offers an important tool for breeding stress‑resilient soybeans, securing food production against extreme weather conditions.
Yangyang Chen, Pingzhang Feng, Mengwei Zheng, Lipei Zhao, Yi Li, Yali Jing, Yisa Wang, Bo Zhang, Changzhong Liu, Chengyu Wei, Jijun Yan, Jinfang Chu, Shanshan Chu, Erhui Xiong, Yongqing Jiao   +14 more
wiley   +1 more source

Intramolecular Interaction of SUR2 Subtypes for Intracellular ADP-Induced Differential Control of K _ATP Channels [PDF]

Circulation Research, 2002
ATP-sensitive K + (K ATP ) channels are composed of sulfonylurea receptors (SURs) and inwardly rectifying Kir6.2-channels. The C-terminal 42 amino acid residues (C42) of SURs are responsible for ADP-induced differential activation of K ATP channels in SUR-subtypes.
Kenji, Matsushita, Kengo, Kinoshita, Tetsuro, Matsuoka, Akikazu, Fujita, Takashi, Fujikado, Yasuo, Tano, Haruki, Nakamura, Yoshihisa, Kurachi   +7 more
openaire   +2 more sources

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Upregulation of ATP-Sensitive Potassium Channels as the Potential Mechanism of Cardioprotection and Vasorelaxation Under the Action of Pyridoxal-5-Phosphate in Old Rats

Journal of Cardiovascular Pharmacology and Therapeutics, 2023
Background: The aging process is accompanied by the weakening of the protective systems of the organism, in particular by the decrease in the expression of ATP-sensitive potassium (K ATP ) channels and in the synthesis of H 2 S.
Ruslan B. Strutynskyi PhD, DSc, Nataliіa A. Strutynska PhD, Oksana O. Piven PhD, DSc, Lidiia A. Mys PhD, Yulia V. Goshovska PhD, Raisa A. Fedichkina PhD, Iryna Y. Okhai (postgraduate), Vladyslav R. Strutynskyi PhD student, Victor E. Dosenko MD, PhD, DSc, Pawel Dobrzyn PhD, DSc, Vadim F. Sagach MD, PhD, DSc   +10 more
doaj   +1 more source

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts. [PDF]

PLoS ONE, 2014
Structural differences between ventricular regions may not be the sole determinant of local ventricular fibrillation (VF) dynamics and molecular remodeling may play a role.To define regional ion channel expression in myopathic hearts compared to normal ...
Gopal Sivagangabalan, Hamed Nazzari, Olivier Bignolais, Ange Maguy, Patrice Naud, Talha Farid, Stéphane Massé, Nathalie Gaborit, Andras Varro, Krishnakumar Nair, Peter Backx, Edward Vigmond, Stanley Nattel, Sophie Demolombe, Kumaraswamy Nanthakumar   +14 more
doaj   +1 more source

Fertilization influences overyielding through dominance of species with high specific leaf area in young tree mixtures

Functional Ecology, Volume 40, Issue 6, Page 1755-1775, June 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract In the context of anthropogenic eutrophication of the biosphere, understanding the impact of nutrient addition on plant diversity–productivity relationships remains a major challenge.
Dai F. Saito, Friderike Beyer, Grégoire T. Freschet, Anja Klingler, Charles A. Nock, Peter B. Reich, Michael Scherer‐Lorenzen, Jürgen Bauhus   +7 more
wiley   +1 more source