Results 61 to 70 of about 2,021 (171)

Intramolecular Interaction of SUR2 Subtypes for Intracellular ADP-Induced Differential Control of K _ATP Channels [PDF]

Circulation Research, 2002
ATP-sensitive K + (K ATP ) channels are composed of sulfonylurea receptors (SURs) and inwardly rectifying Kir6.2-channels. The C-terminal 42 amino acid residues (C42) of SURs are responsible for ADP-induced differential activation of K ATP channels in SUR-subtypes.
Kenji, Matsushita, Kengo, Kinoshita, Tetsuro, Matsuoka, Akikazu, Fujita, Takashi, Fujikado, Yasuo, Tano, Haruki, Nakamura, Yoshihisa, Kurachi   +7 more
openaire   +2 more sources

The synthetic amphipathic peptidomimetic LTX109 is a potent fungicide that disturbs plasma membrane integrity in a sphingolipid dependent manner. [PDF]

PLoS ONE, 2013
The peptidomimetic LTX109 (arginine-tertbutyl tryptophan-arginine-phenylethan) was previously shown to have antibacterial properties. Here, we investigated the activity of this novel antimicrobial peptidomimetic on the yeast Saccharomyces cerevisiae.
Rasmus Bojsen, Rasmus Torbensen, Camilla Eggert Larsen, Anders Folkesson, Birgitte Regenberg   +4 more
doaj   +1 more source

A cytochrome P450 gene, GmSUR2a, confers submergence tolerance and improves yield in soybean by modulating auxin homeostasis

Journal of Integrative Plant Biology, EarlyView.
The key cytochrome P450 gene GmSUR2a enables soybeans to withstand destructive submergence stress. By lowering the level of the plant hormone indole‐3‐acetic acid, this gene improves soybean survival and increases field yield. It offers an important tool for breeding stress‑resilient soybeans, securing food production against extreme weather conditions.
Yangyang Chen, Pingzhang Feng, Mengwei Zheng, Lipei Zhao, Yi Li, Yali Jing, Yisa Wang, Bo Zhang, Changzhong Liu, Chengyu Wei, Jijun Yan, Jinfang Chu, Shanshan Chu, Erhui Xiong, Yongqing Jiao   +14 more
wiley   +1 more source

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1004-1015, October 2026.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source

High‐Throughput DNA Barcoding Reveals Multi‐Trophic Networks of Plants, Leafminers and Parasitoids in a Tropical Dry Forest

Molecular Ecology Resources, Volume 26, Issue 6, August 2026.
ABSTRACT Tropical dry forests host highly diverse insect communities and complex trophic interactions, yet these networks remain difficult to resolve using conventional molecular or rearing‐based approaches. Here, we integrate long‐read DNA barcoding, non‐target sequence co‐amplification, and host plant taxonomy to reconstruct tri‐trophic interactions ...
Ariel H. Muñoz‐Sánchez, Gonzalo Contreras‐Negrete, Alejandro Zaldívar‐Riverón, Rafael Torres Colín, Evgeny V. Zakharov, Carlos López‐Vaamonde, Antonio Hernández‐López   +6 more
wiley   +1 more source

Cantu syndrome-Associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-offunction by differential mechanisms [PDF]

, 2018
The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations
Dragana Josifova, Dorothy K. Grange, Josifova, Dragana, Colin G. Nichols, Van Haaften, Gijs, Monica Sala-Rabanal, Roessler, Helen I., McClenaghan, Conor, Grange, Dorothy K., Nichols, Colin G., Helen I. Roessler, Conor McClenaghan, Sala-Rabanal, Monica, Alex Hanson, Hanson, Alex, Gijs van Haaften   +15 more
core   +2 more sources

Upregulation of ATP-Sensitive Potassium Channels as the Potential Mechanism of Cardioprotection and Vasorelaxation Under the Action of Pyridoxal-5-Phosphate in Old Rats

Journal of Cardiovascular Pharmacology and Therapeutics, 2023
Background: The aging process is accompanied by the weakening of the protective systems of the organism, in particular by the decrease in the expression of ATP-sensitive potassium (K ATP ) channels and in the synthesis of H 2 S.
Ruslan B. Strutynskyi PhD, DSc, Nataliіa A. Strutynska PhD, Oksana O. Piven PhD, DSc, Lidiia A. Mys PhD, Yulia V. Goshovska PhD, Raisa A. Fedichkina PhD, Iryna Y. Okhai (postgraduate), Vladyslav R. Strutynskyi PhD student, Victor E. Dosenko MD, PhD, DSc, Pawel Dobrzyn PhD, DSc, Vadim F. Sagach MD, PhD, DSc   +10 more
doaj   +1 more source

Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English

International Journal of Applied Linguistics, Volume 36, Issue 3, Page 2298-2308, August 2026.
ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley   +1 more source

Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts. [PDF]

PLoS ONE, 2014
Structural differences between ventricular regions may not be the sole determinant of local ventricular fibrillation (VF) dynamics and molecular remodeling may play a role.To define regional ion channel expression in myopathic hearts compared to normal ...
Gopal Sivagangabalan, Hamed Nazzari, Olivier Bignolais, Ange Maguy, Patrice Naud, Talha Farid, Stéphane Massé, Nathalie Gaborit, Andras Varro, Krishnakumar Nair, Peter Backx, Edward Vigmond, Stanley Nattel, Sophie Demolombe, Kumaraswamy Nanthakumar   +14 more
doaj   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, Volume 604, Issue 16, Page 6619-6638, 15 August 2026.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source