Results 71 to 80 of about 2,021 (171)

Disruption of Sur2 -containing K _ATP channels enhances insulin-stimulated glucose uptake in skeletal muscle [PDF]

Proceedings of the National Academy of Sciences, 2001
ATP-sensitive potassium channels (K ATP ) are involved in a diverse array of physiologic functions including protection of tissue against ischemic insult, regulation of vascular tone, and modulation of insulin secretion.
W A, Chutkow, V, Samuel, P A, Hansen, J, Pu, C R, Valdivia, J C, Makielski, C F, Burant   +6 more
openaire   +2 more sources

Cardiac microvascular barrier function mediates the protection of Tongxinluo against myocardial ischemia/reperfusion injury. [PDF]

PLoS ONE, 2015
Tongxinluo (TXL) has been shown to decrease myocardial necrosis after ischemia/reperfusion (I/R) by simulating ischemia preconditioning (IPC). However, the core mechanism of TXL remains unclear.
Kang Qi, Lujin Li, Xiangdong Li, Jinglin Zhao, Yang Wang, Shijie You, Fenghuan Hu, Haitao Zhang, Yutong Cheng, Sheng Kang, Hehe Cui, Lian Duan, Chen Jin, Qingshan Zheng, Yuejin Yang   +14 more
doaj   +1 more source

Assessing relational values of sacred landscapes through text mining of folktales: Insights from the Ryukyu Islands, Japan

People and Nature, Volume 8, Issue 7, Page 2383-2392, July 2026.
Abstract Assessing relational values of nature through its cultural and spiritual significance is crucial for effective nature conservation. Folktales offer insights into traditional relationships between people and nature, and text mining is a powerful tool for extracting information from textual datasets.
Naoki Saito, Soyo Takahashi, Akira Iguchi   +2 more
wiley   +1 more source

SUR2 subtype (A and B)‐dependent differential activation of the cloned ATP‐sensitive K⁺ channels by pinacidil and nicorandil [PDF]

British Journal of Pharmacology, 1998
The classical ATP sensitive K+ (KATP) channels are composed of a sulphonylurea receptor (SUR) and an inward rectifying K+ channel subunit (BIR/Kir6.2). They are the targets of vasorelaxant agents called K+ channel openers, such as pinacidil and nicorandil.
T, Shindo, M, Yamada, S, Isomoto, Y, Horio, Y, Kurachi   +4 more
openaire   +2 more sources

Chamber-specific SUR1 and SUR2 expression does not correlate with CpG island methylation.

, 2013
Total CpG island methylation of SUR1 and SUR2 as measured using either (A) EpiTect assay or (B) bisulfite sequencing. Using either method, SUR1 and SUR2 CpG islands were predominantly unmethylated in both atrial and ventricular genomic DNA.
Willliam C. Claycomb (314777), Naheed Fatima (314771), Thomas P. Flagg (314778), James F. Schooley Jr (314774)   +3 more
core   +1 more source

Chilling Accumulation Shapes Transcriptomic Responses to Warming Exposure During Grapevine Deacclimation

Physiologia Plantarum, Volume 178, Issue 4, July/August 2026.
ABSTRACT During winter, grapevine (Vitis vinifera) bud dormancy and cold hardiness are regulated by complex interactions between chilling accumulation and warm temperature cues. However, the molecular mechanisms underlying physiological transitions during winter remain poorly understood.
Hongrui Wang, Jason P. Londo
wiley   +1 more source

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Draft genome sequence of Chryseobacterium limigenitum SUR2 T (LMG 28734 T ) isolated from dehydrated sludge [PDF]

, 2018
The type strain SUR2 of the novel species Chryseobacterium limigenitum was isolated from a dehydrated sludge of the municipal sewage treatment plant in Dogoše near Maribor in Slovenia. The draft genome, with 60 contigs, 4,697,725bp, 34.4% of G+C content,
Nikos C. Kyrpides, William B. Whitman, Janja Trček, Shapiro, Nicole, Nicole Shapiro, Škraban, Jure, Jure Škraban, Whitman, William B, Trček, Janja, Kyrpides, Nikos C   +9 more
core   +1 more source

Putative subunits of the rat mesangial Katp: A type 2B sulfonylurea receptor and an inwardly rectifying K+ channel [PDF]

, 2002
Background. Sulfonylurea agents exert their physiological effects in many cell types via binding to specific sulfonylurea receptors (SUR). SUR couple to inwardly-rectifying K+ channel (Kir6.x) to form tetradimeric ATP-sensitive K+ channels (KATP).
Alviani, Rebecca, Riser, Bruce L, Zasuwa, Gerald, Cortes, Pedro, Szamosfalvi, Balázs, Asano, Kenichiro, Yee, Jerry   +6 more
core   +2 more sources

Fertilization influences overyielding through dominance of species with high specific leaf area in young tree mixtures

Functional Ecology, Volume 40, Issue 6, Page 1755-1775, June 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract In the context of anthropogenic eutrophication of the biosphere, understanding the impact of nutrient addition on plant diversity–productivity relationships remains a major challenge.
Dai F. Saito, Friderike Beyer, Grégoire T. Freschet, Anja Klingler, Charles A. Nock, Peter B. Reich, Michael Scherer‐Lorenzen, Jürgen Bauhus   +7 more
wiley   +1 more source