Results 91 to 100 of about 1,901 (173)

A haplotype in the human Sur2 gene is associated with essential hypertension [PDF]

Journal of Human Hypertension, 2005
N, Sato, T, Nakayama, S, Asai, M, Soma
openaire   +2 more sources

Chamber-specific SUR1 and SUR2 expression does not correlate with CpG shore methylation.

, 2013
(A) Cartoon illustrating the CpG shore regions comprised of ∼1600 bp upstream of the CpG islands of the SUR1 and SUR2 genes. CpG dinucleotides (asterisks) and specific regions analyzed by bisulfite sequencing are illustrated (dashed lines).
Willliam C. Claycomb (314777), Naheed Fatima (314771), Thomas P. Flagg (314778), James F. Schooley Jr (314774)   +3 more
core   +1 more source

A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels

Neuroscience Research
Epilepsy is a common neurological disorder worldwide. Hydrogen sulfide (H2S) has been found to have anti-seizure effects. However, its mechanism remains to be explored.
Qiyun Kang, Ziting Zhu, Zhongrui Liu, Fei Li, Yan He, Yaru Yang, Xutao Wang, Shuisheng Lei, Zishu Yuan, Xiaoqin Zhu   +9 more
doaj   +1 more source

Cardiomyocyte sulfonylurea receptor 2-K_ATPchannel mediates cardioprotection and ST segment elevation

, 2010
Sulfonylurea receptor-containing ATP-sensitive potassium (KATP) channels have been implicated in cardioprotection, but the cell type and constitution of channels responsible for this protection have not been clear.
Michele Hadhazy, Karel Chalupsky, Jamie Metcalfe, Nitin Aggarwal, Douglas A. Stoller, Jonathan C. Makielski, Bi-Hua Tan, John P. Fahrenbach, Nian-Qing Shi, Elizabeth M. McNally   +9 more
core   +1 more source

Repurposing the Kir6.2/SUR2 Channel Activator Minoxidil to Treat Gynecological Cancers [PDF]

Biophysical Journal, 2020
Vitaly Senyuk, Angela Russo, Margaret Liotta, Ronald Potkul, Craig Beeson, Joanna Burdette, Saverio Gentile   +6 more
openaire   +1 more source

Visual Abstract - Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective: 10.1016/j.jacbts.2018.11.012

, 2019
• In the heart, SUR2 couples with a potassium channel to form an adenosine triphosphate–sensitive complex that responds to the energy state of the cell.• The authors deleted SUR2 in adult cardiomyocytes and found a shift of the heart toward glycolytic ...
Michele Hadhazy (2697553), Alexis R. Demonbreun (6834920), James L. Warner (4532200), Katherine S. Fallon (6820826), Ann E. Rossi (6834923), Jonathan C. Makielski (6834926), Elizabeth M. McNally (6834929), Gregory Aubert (6820820), David Y. Barefield (6820823), Mohun Ramratnam (3390974)   +9 more
core   +1 more source

Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in K_ATP channel gain-of-function by differential mechanisms

, 2017
The complex cardiovascular disorder Cantu Syndrome arises from gain-of-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels.
Helen I. Roessler, Conor McClenaghan, Dragana Josifova, Dorothy K. Grange, Alex Hanson, Colin G. Nichols, Monica Sala-Rabanal, Gijs van Haaften   +7 more
core   +1 more source

FUNCTIONAL KIR2 AND KATP CHANNELS IN HUMAN PULMONARY VASCULAR SMOOTH MUSCLE AND ENDOTHELIUM MODULATE ARTERIAL TONE

Open Respiratory Archives
Introduction: The resting membrane potential (VM) of vascular cells is a major determinant of arterial tone, integrating the activity of multiple ionic conductances.
Bianca Barreira, Daniel Morales-Cano, Laura Moreno, Beatriz de Olaiz, Rui Adão, Ángel Cogolludo, Francisco Pérez-Vizcaíno, María Sancho   +7 more
doaj   +1 more source

Lights and Shadows of the Perception of the Use of Telemedicine by Romanian Family Doctors During the COVID-19 Pandemic

International Journal of General Medicine, 2021
Mira Florea,1 Cecilia Lazea,2 Remus Gaga,2 Genel Sur,2 Lucia Lotrean,1 Aida Puia,1 Ana Maria Alexandra Stanescu,3 Monica Lupsor-Platon,4 Horatiu Florea,5 Maria Lucia Sur2 1Department of Community Medicine, “Iuliu Hatieganu” University of ...
Florea M, Lazea C, Gaga R, Sur G, Lotrean L, Puia A, Stanescu AMA, Lupsor-Platon M, Florea H, Sur ML   +9 more
doaj  

Putative subunits of the rat mesangial KATP: A type 2B sulfonylurea receptor and an inwardly rectifying K+ channel

, 2002
Putative subunits of the rat mesangial KATP: A type 2B sulfonylurea receptor and an inwardly rectifying K+ channel.BackgroundSulfonylurea agents exert their physiological effects in many cell types via binding to specific sulfonylurea receptors (SUR ...
Alviani, Rebecca, Riser, Bruce L, Zasuwa, Gerald, Cortes, Pedro, Zasuwa, Gary, Riser, Bruce L., Szamosfalvi, Balázs, Asano, Kenichiro, Yee, Jerry   +8 more
core   +1 more source