Results 91 to 100 of about 2,021 (171)

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

Disease Models & Mechanisms, 2018
The zebrafish (Danio rerio) has become a popular vertebrate model organism to study organ formation and function due to its optical clarity and rapid embryonic development.
Federico Tessadori, Helen I. Roessler, Sanne M. C. Savelberg, Sonja Chocron, Sarah M. Kamel, Karen J. Duran, Mieke M. van Haelst, Gijs van Haaften, Jeroen Bakkers   +8 more
doaj   +1 more source

A haplotype in the human Sur2 gene is associated with essential hypertension [PDF]

Journal of Human Hypertension, 2005
N, Sato, T, Nakayama, S, Asai, M, Soma
openaire   +2 more sources

Structural Analysis of Sur2391-582 and Discovery of a New ESX-Binding Core of Sur2, Sur2384-521

, 2012
HER2 is overexpressed in metastatic breast cancer and various types of cancer. HER2 is a biomarker indicating poor prognosis and high rate of recurrence. Various types of drugs targeting HER for cancer treatment have been developed.
전경화
core   +1 more source

A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels [PDF]

, 1996
We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6.2 in COS1 cells reconstitutes the properties of KATP channels described in cardiac and skeletal muscle ...
Bryan, Joseph, Seino, Susumu, Gonoi, Tohru, Aguilar-Bryan, Lydia, Inagaki, Nobuya, Iv, John P.Clement, Wang, Chang-Zheng   +6 more
core   +1 more source

Expression, purification and structural analyses of Sur2 protein containing binding core for ESX

, 2011
유방암은 전 세계 여성들에게 발생되는 암이다. 여성 유방암 환자 중 약 30% 정도는 Her2 (human epidermal growth factor receptor 2) 양성 유방암 환자이다. Her2는 인체에서 epidermal growth factor receptor (EGFR : also known as ErbB)의 tyrosine kinases receptor family 중의 하나로 알려져 있다.
김은영
core   +1 more source

A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels

Neuroscience Research
Epilepsy is a common neurological disorder worldwide. Hydrogen sulfide (H2S) has been found to have anti-seizure effects. However, its mechanism remains to be explored.
Qiyun Kang, Ziting Zhu, Zhongrui Liu, Fei Li, Yan He, Yaru Yang, Xutao Wang, Shuisheng Lei, Zishu Yuan, Xiaoqin Zhu   +9 more
doaj   +1 more source

Chamber-specific SUR1 and SUR2 expression does not correlate with CpG shore methylation.

, 2013
(A) Cartoon illustrating the CpG shore regions comprised of ∼1600 bp upstream of the CpG islands of the SUR1 and SUR2 genes. CpG dinucleotides (asterisks) and specific regions analyzed by bisulfite sequencing are illustrated (dashed lines).
Willliam C. Claycomb (314777), Naheed Fatima (314771), Thomas P. Flagg (314778), James F. Schooley Jr (314774)   +3 more
core   +1 more source

Cardiomyocyte sulfonylurea receptor 2-K_ATPchannel mediates cardioprotection and ST segment elevation

, 2010
Sulfonylurea receptor-containing ATP-sensitive potassium (KATP) channels have been implicated in cardioprotection, but the cell type and constitution of channels responsible for this protection have not been clear.
Michele Hadhazy, Karel Chalupsky, Jamie Metcalfe, Nitin Aggarwal, Douglas A. Stoller, Jonathan C. Makielski, Bi-Hua Tan, John P. Fahrenbach, Nian-Qing Shi, Elizabeth M. McNally   +9 more
core   +1 more source

Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in K_ATP channel gain-of-function by differential mechanisms

, 2017
The complex cardiovascular disorder Cantu Syndrome arises from gain-of-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels.
Helen I. Roessler, Conor McClenaghan, Dragana Josifova, Dorothy K. Grange, Alex Hanson, Colin G. Nichols, Monica Sala-Rabanal, Gijs van Haaften   +7 more
core   +1 more source

Functional Consequences of Cantu Syndrome Associated Mutations in the ATP Sensitive Potassium Channel [PDF]

, 2015
ATP-sensitive potassium (KATP) channels are composed of inward-rectifying potassium channel pore-forming subunits (Kir6.1 and Kir6.2, encoded by KCNJ8 and KCNJ11, respectively) and regulatory sulfonylurea receptor subunits (SUR1 and SUR2, encoded by ...
Cooper, Paige
core   +1 more source