Results 101 to 110 of about 2,021 (171)

FUNCTIONAL KIR2 AND KATP CHANNELS IN HUMAN PULMONARY VASCULAR SMOOTH MUSCLE AND ENDOTHELIUM MODULATE ARTERIAL TONE

Open Respiratory Archives
Introduction: The resting membrane potential (VM) of vascular cells is a major determinant of arterial tone, integrating the activity of multiple ionic conductances.
Bianca Barreira, Daniel Morales-Cano, Laura Moreno, Beatriz de Olaiz, Rui Adão, Ángel Cogolludo, Francisco Pérez-Vizcaíno, María Sancho   +7 more
doaj   +1 more source

Lights and Shadows of the Perception of the Use of Telemedicine by Romanian Family Doctors During the COVID-19 Pandemic

International Journal of General Medicine, 2021
Mira Florea,1 Cecilia Lazea,2 Remus Gaga,2 Genel Sur,2 Lucia Lotrean,1 Aida Puia,1 Ana Maria Alexandra Stanescu,3 Monica Lupsor-Platon,4 Horatiu Florea,5 Maria Lucia Sur2 1Department of Community Medicine, “Iuliu Hatieganu” University of ...
Florea M, Lazea C, Gaga R, Sur G, Lotrean L, Puia A, Stanescu AMA, Lupsor-Platon M, Florea H, Sur ML   +9 more
doaj  

Visual Abstract - Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective: 10.1016/j.jacbts.2018.11.012

, 2019
• In the heart, SUR2 couples with a potassium channel to form an adenosine triphosphate–sensitive complex that responds to the energy state of the cell.• The authors deleted SUR2 in adult cardiomyocytes and found a shift of the heart toward glycolytic ...
Michele Hadhazy (2697553), Alexis R. Demonbreun (6834920), James L. Warner (4532200), Katherine S. Fallon (6820826), Ann E. Rossi (6834923), Jonathan C. Makielski (6834926), Elizabeth M. McNally (6834929), Gregory Aubert (6820820), David Y. Barefield (6820823), Mohun Ramratnam (3390974)   +9 more
core   +1 more source

Repurposing the Kir6.2/SUR2 Channel Activator Minoxidil to Treat Gynecological Cancers [PDF]

Biophysical Journal, 2020
Vitaly Senyuk, Angela Russo, Margaret Liotta, Ronald Potkul, Craig Beeson, Joanna Burdette, Saverio Gentile   +6 more
openaire   +1 more source

KATP channel subunits are expressed in the epididymal epithelium in several mammalian species.

, 2008
Adenosine triphosphate-sensitive K(++) (K(ATP)) channels are poorly characterized in the reproductive tract. The present study was designed to evaluate the putative expression of K(ATP) channel subunits (Kir6.x and SURx) in the epididymis from different ...
Petein, Michel, Lybaert, Pascale, Vanbellinghen, Anne-Marie, Quertinmont, Eric, Meuris, Sylvain, Lebrun, Philippe   +5 more
core   +1 more source

The role of survivin2 in primitive hematopoiesis during zebrafish development

, 2009
Survivin is an inhibitor of apoptosis and its role in embryonic development is not completely understood. In zebrafish, survivin undergoes gene duplication. Survivin1 (sur1) has been shown to mediate angiogenesis but not hematopoiesis.
Chung, MIS, Leung, AYH, Liang, R, Ma, ACH   +3 more
core   +1 more source

Figure 1: Selective Ablation of

, 2019
(A)Abcc9 encodes sulfonylurea receptor 2 (SUR2), the major SUR expressed in the myocardium. Shown is a schematic of Abcc9-produced transcripts encoding SUR2 full-length and SUR2-55KDa forms. Exon 5 is shown in red. (B) Shown is a depiction of full-length
Michele Hadhazy (2697553), James L. Warner (4532200), Katherine S. Fallon (6820826), Ann E. Rossi (790669), Elizabeth M. McNally (530976), Alexis R. Demonbreun (790667), Gregory Aubert (6820820), Jonathan C. Makielski (731968), David Y. Barefield (6820823), Mohun Ramratnam (3390974)   +9 more
core   +1 more source

Підвищення експресії АТФ-чутливих калієвих каналів асоціюється з посиленням вазодилататорних реакцій та антиішемічним захистом

, 2022
Вперше показано, що пероральне введення піридоксаль-5-фосфату дорослим щурам майже вдвічі підвищувало експресію мРНК пороутворюючої Kir6.2 та регуляторної SUR2 субодиниць кардіоспецифічних сарколемальних КАТФ-каналів серцевого типу, та у 1,5 раза ...
Сулима Ігор Миколайович
core  

Regional SURx subunit transcription in the mouse heart.

, 2013
Relative mRNA expression of SUR1 and SUR2 obtained in atrial and ventricular tissue (n = 3 hearts each). Expression (normalized to Hprt) was assessed by quantitative RT-PCR.
Willliam C. Claycomb (314777), Naheed Fatima (314771), Thomas P. Flagg (314778), James F. Schooley Jr (314774)   +3 more
core   +1 more source

Sulfonylurea Receptor-Dependent and -Independent Pathways Mediate Vasodilation Induced by KATP Channel Openers. Mol Pharmacol 2008 May 29;74:736-43. Supplemental Figure Legends Supplemental Figure 2. Pregabalin blocks voltage-dependent Ba2+ currents, but

, 2020
ATP-sensitive K ϩ (K ATP ) channel openers are vasodilators that activate both plasma membrane and mitochondrial K ATP channels. Here, we investigated the molecular mechanisms by which diazoxide and pinacidil induce vasodilation by studying diameter ...
Elizabeth M Mcnally, Jonathan H Jaggar, Adebowale Adebiyi   +2 more
core