Results 81 to 90 of about 2,021 (171)

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat

Journal of Pharmacological Sciences, 2016
The lower esophageal sphincter (LES) is a specialized region of the esophageal smooth muscle that allows the passage of a swallowed bolus into the stomach. Nitric oxide (NO) plays a major role in LES relaxation.
Tomonori Shimbo, Takeshi Adachi, Susumu Fujisawa, Mai Hongoh, Takayoshi Ohba, Kyoichi Ono   +5 more
doaj   +1 more source

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, Volume 37, Issue 3, Page 353-364, June 2026.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis

Veterinary Dermatology, Volume 37, Issue 3, Page 365-374, June 2026.
ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake, Melissa P. Swan, Kari J. Ekenstedt   +2 more
wiley   +1 more source

CpG methylation in the CpG island of SUR1 and SUR2 gene in HL-1

, 2013
cells. Shown are data obtained from bisulfite sequencing of the (A) SUR1 and (B) SUR2 sequences. 4152 and 5304 individual sequences were analyzed for SUR1 and SUR2, respectively.
Willliam C. Claycomb (314777), Naheed Fatima (314771), Thomas P. Flagg (314778), James F. Schooley Jr (314774)   +3 more
core   +1 more source

The Voice of Cantú: Lower Voice Pitch Is a New Phenotypic Feature of Cantú Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1062-1068, May 2026.
ABSTRACT Cantú syndrome (CS) is a rare genetic condition caused by pathogenic variants in either ABCC9 or KCNJ8, leading to gain‐of‐function of KATP‐channels. The main clinical features are hypertrichosis and cardiovascular abnormalities. This study investigates the voice characteristics in individuals with CS, an aspect that has received little ...
Lotte Kleinendorst, Melanie N. S. Molegraaf, Dorothy K. Grange, Rico N. P. M. Rinkel, Mieke M. van Haelst   +4 more
wiley   +1 more source

Generation cycles in experimental populations of a multivoltine insect

Journal of Animal Ecology, Volume 95, Issue 5, Page 782-794, May 2026.
Although theory suggests various mechanisms by which environmental and ecological factors may drive generational fluctuations, our field‐cage experiment is the first to demonstrate how internal dynamics and external disturbances jointly produce synchronised, large‐scale outbreak cycles.
Takehiko Yamanaka, Yasushi Sato, William A. Nelson, Ottar N. Bjørnstad   +3 more
wiley   +1 more source

ATP sensitive potassium channels in the skeletal muscle functions : involvement of the KCNJ11(Kir6.2) gene in the determination of Warner Bratzer shear force

Frontiers in Physiology, 2016
The ATP-sensitive K+-channels (KATP) are distributed in the tissues coupling metabolism with K+ ions efflux. KATP subunits are encoded by KCNJ8 (Kir6.1), KCNJ11 (Kir6.2), ABCC8 (SUR1) and ABCC9 (SUR2) genes, alternative RNA splicing give rise to SUR ...
Domenico eTricarico, Maria eSelvaggi, Giuseppe ePassantino, Pasquale eDe Palo, Dario eCataldo, Pasquale eCentoducati, Alessandra eTateo, Angela eCurci, Fatima eMaquod, Antonietta eMele, Giulia Maria eCamerino, Antonella eLiantonio, Paola eImbrici, Nicola eZizzo   +13 more
doaj   +1 more source

Large mammal recovery in the wake of human population decline

Journal of Applied Ecology, Volume 63, Issue 5, May 2026.
Human depopulation, particularly in rural areas, has contributed to the recovery of some large mammal populations. While recovery is generally good news for conservation, it can also lead to human‐wildlife conflict. We present several avenues to maximize coexistence in the face of further rural depopulation in other places. Read the free Plain Language
Alex J. Jensen, Benjamin R. Goldstein, Keita Fukasawa, Fabiola Iannarilli, Roland Kays   +4 more
wiley   +1 more source

Treatment with 5′-Aza-2′-deoxycitidine (Aza-dC) causes CpG island demethylation and increased expression of SUR2 in HL-1

, 2013
cells. (A) Unmethylated fraction SUR2 CpG island (○) and relative SUR2 mRNA expression (•) at varying doses of Aza-dC. (B) Unmethylated SUR1 CpG island fraction and SUR1 subunit mRNA expression before and after treatment with 10 µM Aza-dC.
Willliam C. Claycomb (314777), Naheed Fatima (314771), Thomas P. Flagg (314778), James F. Schooley Jr (314774)   +3 more
core   +1 more source