Results 21 to 30 of about 1,901 (173)

Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice

American Journal of Physiology-Heart and Circulatory Physiology, 2011
Physiological functions of arterial smooth muscle cell ATP-sensitive K+(KATP) channels, which are composed of inwardly rectifying K+channel 6.1 and sulfonylurea receptor (SUR)-2 subunits, during metabolic inhibition are unresolved. In the present study, we used a genetic model to investigate the physiological functions of SUR2-containing KATPchannels ...
Adebowale, Adebiyi, Elizabeth M, McNally, Jonathan H, Jaggar   +2 more
openaire   +4 more sources

Zoledronic Acid as a Novel Dual Blocker of KIR6.1/2-SUR2 Subunits of ATP-Sensitive K⁺ Channels: Role in the Adverse Drug Reactions [PDF]

Pharmaceutics, 2021
Zoledronic acid (ZOL) is used as a bone-specific antiresorptive drug with antimyeloma effects. Adverse drug reactions (A.D.R.) are associated with ZOL-therapy, whose mechanics are unknown.
Fatima Maqoud, Rosa Scala, Vincenzo Tragni, Ciro Leonardo Pierri, Maria Grazia Perrone, Antonio Scilimati, Domenico Tricarico   +6 more
doaj   +2 more sources

Endosomal K_ATPchannels as a reservoir after myocardial ischemia: a role for SUR2 subunits

American Journal of Physiology-Heart and Circulatory Physiology, 2011
ATP-sensitive K+(KATP) channels, composed of inward rectifier K+(Kir)6.x and sulfonylurea receptor (SUR)x subunits, are expressed on cellular plasma membranes. We demonstrate an essential role for SUR2 subunits in trafficking KATPchannels to an intracellular vesicular compartment.
Li, Bao, Krassimira, Hadjiolova, William A, Coetzee, Michael J, Rindler   +3 more
openaire   +4 more sources

Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis

Frontiers in Pharmacology, 2015
Histone deacetylase inhibitors (HDIs) are under investigation for the treatment of a number of human health problems. HDIs have proven therapeutic value in refractory cases of cutaneous T-cell lymphoma,.
Naheed eFatima, Devin C Cohen, Gauthaman eSukumar, Tristan M Sissung, James F Schooley, Mark C Haigney, William C Claycomb, Rachel T Cox, Clifton Lee Dalgard, Susan E. Bates, Thomas P Flagg   +10 more
doaj   +2 more sources

Electrophysiology of Human iPSC-derived Vascular Smooth Muscle Cells and Cell-autonomous Consequences of Cantú Syndrome Mutations [PDF]

Function
Cantú syndrome (CS), a multisystem disease with a complex cardiovascular phenotype, is caused by gain-of-function (GoF) variants in the Kir6.1/SUR2 subunits of ATP-sensitive potassium (KATP) channels and is characterized by low systemic vascular ...
Alex Hanson, Conor McClenaghan, Kuo-Chan Weng, Sarah Colijn, Amber N Stratman, Carmen M Halabi, Dorothy K Grange, Jonathan R Silva, Colin G Nichols   +8 more
doaj   +2 more sources

The Kir6.2‐F333I mutation differentially modulates K_ATP channels composed of SUR1 or SUR2 subunits

The Journal of Physiology, 2007
Mutations in Kir6.2, the pore‐forming subunit of the KATP channel, that reduce the ability of ATP to block the channel cause neonatal diabetes. The stimulatory effect of MgATP mediated by the regulatory sulphonylurea receptor (SUR) subunit of the channel may also be modified.
Tammaro, Paolo, Ashcroft, Frances
openaire   +5 more sources

Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii

Yeast, 2004
AbstractSaccharomyces cerevisiae sphinganine C4‐hydroxylase encoded by the SUR2 gene catalyses the conversion of sphinganine to phytosphingosine. We isolated the SUR2 gene from Pichia ciferrii using nucleotide sequence homology to S. cerevisiae SUR2 to study hydroxylation of sphinganine in the sphingoid base overproducing yeast P. ciferrii.
Bae, JH, Sohn, JH, Park, CS, Rhee, JS Rhee, Joon Shick, Choi, ES   +4 more
openaire   +4 more sources

Replication-IDentifier links epigenetic and metabolic pathways to the replication stress response [PDF]

Nature Communications
Perturbation of DNA replication, for instance by hydroxyurea-dependent dNTP exhaustion, often leads to stalling or collapse of replication forks. This triggers a replication stress response that stabilizes these forks, activates cell cycle checkpoints ...
Sophie C. van der Horst, Leonie Kollenstart, Amandine Batté, Sander Keizer, Kees Vreeken, Praveen Pandey, Andrei Chabes, Haico van Attikum   +7 more
doaj   +2 more sources

Novel human ABCC9/SUR2 brain‐expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging

Journal of Neurochemistry, 2015
AbstractABCC9 genetic polymorphisms are associated with increased risk for various human diseases including hippocampal sclerosis of aging. The main goals of this study were 1 > to detect the ABCC9 variants and define the specific 3′ untranslated region (3′UTR) for each variant in human brain, and 2 > to determine whether a polymorphism (rs704180)
Peter T, Nelson, Wang-Xia, Wang, Bernard R, Wilfred, Angela, Wei, James, Dimayuga, Qingwei, Huang, Eseosa, Ighodaro, Sergey, Artiushin, David W, Fardo   +8 more
openaire   +5 more sources

The Functional Interaction of KATP and BK Channels with Aquaporin-4 in the U87 Glioblastoma Cell [PDF]

Biomedicines
K+ channels do play a role in cell shape changes observed during cell proliferation and apoptosis. Research suggested that the dynamics of the aggregation of Aquaporin-4 (AQP4) into AQP4-OAP isoforms can trigger cell shape changes in malignant glioma ...
Fatima Maqoud, Laura Simone, Domenico Tricarico, Giulia Maria Camerino, Marina Antonacci, Grazia Paola Nicchia   +5 more
doaj   +2 more sources