Results 11 to 20 of about 151,712 (215)

Greater cognitive reserve is related to lower cortical excitability in healthy cognitive aging, but not in early clinical Alzheimer’s disease

Frontiers in Human Neuroscience, 2023
ObjectiveTo investigate the relationship between cortico-motor excitability and cognitive reserve (CR) in cognitively unimpaired older adults (CU) and in older adults with mild cognitive impairment or mild dementia due to Alzheimer’s disease (AD ...
Stephanie S. Buss, Stephanie S. Buss, Peter J. Fried, Peter J. Fried, Joanna Macone, Joanna Macone, Victor Zeng, Emma Zingg, Emma Zingg, Emiliano Santarnecchi, Emiliano Santarnecchi, Emiliano Santarnecchi, Alvaro Pascual-Leone, Alvaro Pascual-Leone, David Bartrés-Faz, David Bartrés-Faz, David Bartrés-Faz   +16 more
doaj   +1 more source

Minimal requirements for a neuron to coregulate many properties and the implications for ion channel correlations and robustness

eLife, 2022
Neurons regulate their excitability by adjusting their ion channel levels. Degeneracy – achieving equivalent outcomes (excitability) using different solutions (channel combinations) – facilitates this regulation by enabling a disruptive change in one ...
Jane Yang, Husain Shakil, Stéphanie Ratté, Steven A Prescott   +3 more
doaj   +1 more source

Homogeneous and Narrow Bandwidth of Spike Initiation in Rat L1 Cortical Interneurons

Frontiers in Cellular Neuroscience, 2020
The cortical layer 1 (L1) contains a population of GABAergic interneurons, considered a key component of information integration, processing, and relaying in neocortical networks.
Stefano Borda Bossana, Christophe Verbist, Michele Giugliano, Michele Giugliano   +3 more
doaj   +1 more source

Subunit gating resulting from individual protonation events in Kir2 channels

Nature Communications, 2023
Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore.
Grigory Maksaev, Michael Bründl-Jirout, Anna Stary-Weinzinger, Eva-Maria Zangerl-Plessl, Sun-Joo Lee, Colin G. Nichols   +5 more
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Estradiol decreases the excitability of RA projection neurons in adult male zebra finches

Frontiers in Cellular Neuroscience, 2023
Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior.
Yutao Zhang, Yalun Sun, Yanran Wu, Wei Sun, Kun Zhang, Wei Meng, Songhua Wang   +6 more
doaj   +1 more source

Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model

Frontiers in Pharmacology, 2019
The cardiac Nav1.5 mediated sodium current (INa) generates the upstroke of the action potential in atrial and ventricular myocytes. Drugs that modulate this current can therefore be antiarrhythmic or proarrhythmic, which requires preclinical evaluation ...
Dieter V. Van de Sande, Ivan Kopljar, Ivan Kopljar, Ard Teisman, David J. Gallacher, Dirk J. Snyders, Hua Rong Lu, Alain J. Labro   +7 more
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Effect of the Lippia alba (Mill.) N.E. Brown essential oil and its main constituents, citral and limonene, on the tracheal smooth muscle of rats

Biotechnology Reports, 2018
The Lippia alba (Mill.) N.E. Brown (Verbenaceae) species, has effects sedative, analgesic and spasmolytic properties. This study had as its main objective to evaluate the essential oil of L.
Poliana M.M. Carvalho, Cícero A.F. Macêdo, Tiago F. Ribeiro, Andressa A. Silva, Renata E.R. Da Silva, Luís P. de Morais, Marta R. Kerntopf, Irwin R.A. Menezes, Roseli Barbosa   +8 more
doaj   +1 more source

Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation

Nature Communications, 2020
In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism during voltage-
Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli McFarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui   +14 more
doaj   +1 more source

Sodium Channels Involved in the Initiation of Action Potentials in Invertebrate and Mammalian Neurons

Biophysica, 2022
Living organisms react to external stimuli to adapt their activity to the environment for survival. Acquired information is encoded by neurons by action potentials (APs) in a series of discrete electrical events.
Daria Y Romanova, Pavel M Balaban, Evgeny S Nikitin   +2 more
doaj   +1 more source

Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

Nature Communications, 2017
KCNQ1 is a voltage-gated potassium channel that is important in cardiac and epithelial function. Here the authors present a mechanism for KCNQ1 activation and inactivation in which voltage sensor activation promotes pore opening more effectively in the ...
Panpan Hou, Jodene Eldstrom, Jingyi Shi, Ling Zhong, Kelli McFarland, Yuan Gao, David Fedida, Jianmin Cui   +7 more
doaj   +1 more source