Results 21 to 30 of about 145,655 (269)

Estradiol decreases the excitability of RA projection neurons in adult male zebra finches

Frontiers in Cellular Neuroscience, 2023
Zebra finches are essential animal models for studying learned vocal signals. The robust nucleus of the arcopallium (RA) plays an important role in regulating singing behavior.
Yutao Zhang, Yalun Sun, Yanran Wu, Wei Sun, Kun Zhang, Wei Meng, Songhua Wang   +6 more
doaj   +1 more source

Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model

Frontiers in Pharmacology, 2019
The cardiac Nav1.5 mediated sodium current (INa) generates the upstroke of the action potential in atrial and ventricular myocytes. Drugs that modulate this current can therefore be antiarrhythmic or proarrhythmic, which requires preclinical evaluation ...
Dieter V. Van de Sande, Ivan Kopljar, Ivan Kopljar, Ard Teisman, David J. Gallacher, Dirk J. Snyders, Hua Rong Lu, Alain J. Labro   +7 more
doaj   +1 more source

Effect of the Lippia alba (Mill.) N.E. Brown essential oil and its main constituents, citral and limonene, on the tracheal smooth muscle of rats

Biotechnology Reports, 2018
The Lippia alba (Mill.) N.E. Brown (Verbenaceae) species, has effects sedative, analgesic and spasmolytic properties. This study had as its main objective to evaluate the essential oil of L.
Poliana M.M. Carvalho, Cícero A.F. Macêdo, Tiago F. Ribeiro, Andressa A. Silva, Renata E.R. Da Silva, Luís P. de Morais, Marta R. Kerntopf, Irwin R.A. Menezes, Roseli Barbosa   +8 more
doaj   +1 more source

Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

Nature Communications, 2017
KCNQ1 is a voltage-gated potassium channel that is important in cardiac and epithelial function. Here the authors present a mechanism for KCNQ1 activation and inactivation in which voltage sensor activation promotes pore opening more effectively in the ...
Panpan Hou, Jodene Eldstrom, Jingyi Shi, Ling Zhong, Kelli McFarland, Yuan Gao, David Fedida, Jianmin Cui   +7 more
doaj   +1 more source

Sodium Channels Involved in the Initiation of Action Potentials in Invertebrate and Mammalian Neurons

Biophysica, 2022
Living organisms react to external stimuli to adapt their activity to the environment for survival. Acquired information is encoded by neurons by action potentials (APs) in a series of discrete electrical events.
Daria Y Romanova, Pavel M Balaban, Evgeny S Nikitin   +2 more
doaj   +1 more source

Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation

Nature Communications, 2020
In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism during voltage-
Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli McFarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui   +14 more
doaj   +1 more source

Bio-Mimicking, Electrical Excitability Phenomena Associated With Synthetic Macromolecular Systems: A Brief Review With Connections to the Cytoskeleton and Membraneless Organelles

Frontiers in Molecular Neuroscience, 2022
Electrical excitability of cells, tissues and organs is a fundamental phenomenon in biology and physiology. Signatures of excitability include transient currents resulting from a constant or varying voltage gradient across compartments.
Gary E. Wnek, Alberto C. S. Costa, Alberto C. S. Costa, Susan K. Kozawa   +3 more
doaj   +1 more source

Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels

eLife, 2021
Increasing extracellular [Ca2+] ([Ca2+]o) strongly decreases intrinsic excitability in neurons but the mechanism is unclear. By one hypothesis, [Ca2+]o screens surface charge, reducing voltage-gated sodium channel (VGSC) activation and by another [Ca2+]o
Briana J Martiszus, Timur Tsintsadze, Wenhan Chang, Stephen M Smith   +3 more
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Publisher Correction: Hydrophobic gating in BK channels

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Zhiguang Jia, Mahdieh Yazdani, Guohui Zhang, Jianmin Cui, Jianhan Chen   +4 more
doaj   +1 more source

Circuit-level theories for sensory dysfunction in autism: convergence across mouse models

Frontiers in Neurology, 2023
Individuals with autism spectrum disorder (ASD) exhibit a diverse range of behavioral features and genetic backgrounds, but whether different genetic forms of autism involve convergent pathophysiology of brain function is unknown.
Hannah R. Monday, Han Chin Wang, Daniel E. Feldman   +2 more
doaj   +1 more source