Results 1 to 10 of about 31,667 (251)
Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico. [PDF]
PLoS Computational BiologyReduced cortical inhibition by parvalbumin-expressing (PV) interneurons in schizophrenia is thought to be associated with impaired processing in the prefrontal cortex and altered EEG signals such as oddball mismatch negativity (MMN).
Sana Rosanally +5 more
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Aberrant medial ganglionic eminence (MGE) GABAergic neurogenesis contributes to Huntington's disease pathogenesis [PDF]
Neurobiology of DiseaseAlthough early telencephalic interneuron dysfunction in animal models and cortical interneuron deficits in Huntington's disease (HD) have been documented, their developmental origins and causal contributions to disease pathogenesis remain incompletely ...
Aldrin E. Molero +6 more
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Cell Reports, 2019 Summary: Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the
Emily Ling-Lin Pai +2 more
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Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication [PDF]
Nature CommunicationsEmerging evidence links oligodendrocyte (OL) lineage cells and myelin to cognitive processes, yet the role of myelination in shaping neuronal networks critical for cognitive tasks remains unknown.
Fabrice Plaisier +6 more
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Spinal interneuron population dynamics underlying flexible pattern generation [PDF]
Nature CommunicationsThe mammalian spinal locomotor network is composed of diverse populations of interneurons that collectively orchestrate and execute a range of locomotor behaviors.
Lahiru N. Wimalasena +2 more
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In-silico EEG biomarkers of reduced inhibition in human cortical microcircuits in depression.
PLoS Computational Biology, 2023 Reduced cortical inhibition by somatostatin-expressing (SST) interneurons has been strongly associated with treatment-resistant depression. However, due to technical limitations it is impossible to establish experimentally in humans whether the effects ...
Frank Mazza +4 more
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Frontiers in Synaptic Neuroscience, 2022 General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous
Iris A. Speigel +2 more
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Cellular signaling impacts upon GABAergic cortical interneuron development
Frontiers in Neuroscience, 2023 The development and maturation of cortical GABAergic interneurons has been extensively studied, with much focus on nuclear regulation via transcription factors.
Emily Ling-Lin Pai +3 more
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eLife, 2020 In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity.
Igor Gridchyn +3 more
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A Novel LHX6 Reporter Cell Line for Tracking Human iPSC-Derived Cortical Interneurons
Cells, 2022 GABAergic interneurons control the neural circuitry and network activity in the brain. The dysfunction of cortical interneurons, especially those derived from the medial ganglionic eminence, contributes to neurological disease states.
Maria Cruz-Santos +2 more
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