Results 1 to 10 of about 57,978 (299)

Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations [PDF]

open access: yes, 2003
Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling?
Bibbig, A.   +7 more
core   +2 more sources

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

open access: yeseLife, 2016
Interneurons are critical for proper neural network function and can activate Ca2+ signaling in astrocytes. However, the impact of the interneuron-astrocyte signaling into neuronal network operation remains unknown.
Gertrudis Perea   +18 more
doaj   +1 more source

Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

open access: yeseLife, 2021
Cortical interneurons establish inhibitory microcircuits throughout the neocortex and their dysfunction has been implicated in epilepsy and neuropsychiatric diseases.
Matthieu Genestine   +14 more
doaj   +1 more source

New insights into the classification and nomenclature of cortical GABAergic interneurons. [PDF]

open access: yes, 2013
A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web ...
A Karagiannis   +82 more
core   +3 more sources

Application of cluster analysis in morphological characteristics of neurons

open access: yes浙江大学学报. 农业与生命科学版, 2011
Base on the data for three dimensional (3D) coordinate of 49 neurons, 16 morphological parameters were obtained by calculation. According to the factor analysis of the morphological parameters, three major characteristics, including dimension, degree of ...
ZHANG Jing   +5 more
doaj   +1 more source

Modifying PCDH19 levels affects cortical interneuron migration

open access: yesFrontiers in Neuroscience, 2022
PCDH19 is a transmembrane protein and member of the protocadherin family. It is encoded by the X-chromosome and more than 200 mutations have been linked to the neurodevelopmental PCDH-clustering epilepsy (PCDH19-CE) syndrome.
Anna Pancho   +20 more
doaj   +1 more source

The cellular and synaptic architecture of the mechanosensory dorsal horn [PDF]

open access: yes, 2017
The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR ...
Abraira   +80 more
core   +1 more source

Divisive Inhibition Prevails During Simultaneous Optogenetic Activation of All Interneuron Subtypes in Mouse Primary Visual Cortex

open access: yesFrontiers in Neural Circuits, 2019
The mouse primary visual cortex (V1) has become an important brain area for exploring how neural circuits process information. Optogenetic tools have helped to outline the connectivity of a local V1 circuit comprising excitatory pyramidal neurons and ...
Tony G. J. Ingram   +2 more
doaj   +1 more source

Medial Ganglionic Eminence Progenitors Transplanted into Hippocampus Integrate in a Functional and Subtype-Appropriate Manner. [PDF]

open access: yes, 2017
Medial ganglionic eminence (MGE) transplantation rescues disease phenotypes in various preclinical models with interneuron deficiency or dysfunction, including epilepsy.
Baraban, Scott C, Hsieh, Jui-Yi
core   +1 more source

Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain

open access: yesStem Cell Research, 2018
GABAergic interneuron dysfunction has been implicated in temporal lobe epilepsy (TLE), autism, and schizophrenia. Inhibitory interneuron progenitors transplanted into the hippocampus of rodents with TLE provide varying degrees of seizure suppression.
Nickesha C. Anderson   +11 more
doaj   +1 more source

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