Results 31 to 40 of about 40,471 (297)

Application of cluster analysis in morphological characteristics of neurons

浙江大学学报. 农业与生命科学版, 2011
Base on the data for three dimensional (3D) coordinate of 49 neurons, 16 morphological parameters were obtained by calculation. According to the factor analysis of the morphological parameters, three major characteristics, including dimension, degree of ...
ZHANG Jing, DENG Shi-huai, GUO Hang, SHEN Fei, GU Wei-gang, LI Yuan-wei   +5 more
doaj   +1 more source

Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain

Stem Cell Research, 2018
GABAergic interneuron dysfunction has been implicated in temporal lobe epilepsy (TLE), autism, and schizophrenia. Inhibitory interneuron progenitors transplanted into the hippocampus of rodents with TLE provide varying degrees of seizure suppression.
Nickesha C. Anderson, Meghan A. Van Zandt, Swechhya Shrestha, Daniel B. Lawrence, Jyoti Gupta, Christopher Y. Chen, Felicia A. Harrsch, Trinithas Boyi, Carolyn E. Dundes, Gloster Aaron, Janice R. Naegele, Laura Grabel   +11 more
doaj   +1 more source

Cortical interneurons in autism

Nature Neuroscience, 2021
The mechanistic underpinnings of autism remain a subject of debate and controversy. Why do individuals with autism share an overlapping set of atypical behaviors and symptoms, despite having different genetic and environmental risk factors? A major challenge in developing new therapies for autism has been the inability to identify convergent neural ...
Anis Contractor, Iryna M. Ethell, Carlos Portera-Cailliau   +2 more
openaire   +4 more sources

Divisive Inhibition Prevails During Simultaneous Optogenetic Activation of All Interneuron Subtypes in Mouse Primary Visual Cortex

Frontiers in Neural Circuits, 2019
The mouse primary visual cortex (V1) has become an important brain area for exploring how neural circuits process information. Optogenetic tools have helped to outline the connectivity of a local V1 circuit comprising excitatory pyramidal neurons and ...
Tony G. J. Ingram, Jillian L. King, Nathan A. Crowder   +2 more
doaj   +1 more source

Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo

Cell Reports, 2020
Summary: The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood.
Charlotte Arlt, Michael Häusser
doaj   +1 more source

Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes

Cell Reports, 2021
Summary: GABAergic interneurons migrate long distances through stereotyped migration programs toward specific laminar positions. During their migration, GABAergic interneurons are morphologically alike but then differentiate into a rich array of ...
Christelle Cadilhac, Isabelle Bachy, Antoine Forget, David J. Hodson, Céline Jahannault-Talignani, Andrew J. Furley, Olivier Ayrault, Patrice Mollard, Constantino Sotelo, Fabrice Ango   +9 more
doaj   +1 more source

Data_Sheet_1_Modifying PCDH19 levels affects cortical interneuron migration.pdf

, 2022
PCDH19 is a transmembrane protein and member of the protocadherin family. It is encoded by the X-chromosome and more than 200 mutations have been linked to the neurodevelopmental PCDH-clustering epilepsy (PCDH19-CE) syndrome.
Anne Stulens (14007519), Lieve Geenen (14007516), Katrien Staes (74591), Marco Dalla Vecchia (14007513), Eve Seuntjens (175798), Paco Hulpiau (86349), Anna Pancho (10043876), Tania Aerts (10043879), Lena K. Ebert (5171531), Lut Noterdaeme (10043888), Frans Van Roy (12849), Manuela D. Mitsogiannis (10043873), Peter Dedecker (1316553), Ria Vanlaer (10043885), Bernhard Schermer (159386)   +14 more
core   +1 more source

Local axonal morphology guides the topography of interneuron myelination in mouse and human neocortex

eLife, 2019
GABAergic fast-spiking parvalbumin-positive (PV) interneurons are frequently myelinated in the cerebral cortex. However, the factors governing the topography of cortical interneuron myelination remain incompletely understood.
Jeffrey Stedehouder, Demi Brizee, Johan A Slotman, Maria Pascual-Garcia, Megan L Leyrer, Bibi LJ Bouwen, Clemens MF Dirven, Zhenyu Gao, David M Berson, Adriaan B Houtsmuller, Steven A Kushner   +10 more
doaj   +1 more source

Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

eLife, 2022
Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth factor 15 (FGF15), a motogen ...
Rachana Deven Somaiya, Katelyn Stebbins, Ellen C Gingrich, Hehuang Xie, John N Campbell, A Denise R Garcia, Michael A Fox   +6 more
doaj   +1 more source

Interneurons Scratch an Itch [PDF]

Neuron, 2014
Itch is immensely frustrating. Most studies focus on the cause of itch. In this issue of Neuron, Kardon et al. (2014) find that itch can be modulated by inhibitory neurons that produce dynorphin, an endogenous agonist of κ-opioid receptors.
Pereira, Paula Juliana Seadi, Lerner, Ethan A.   +1 more
openaire   +2 more sources