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Cortical interneurons represent 20% of the cells in the cortex. These cells are local inhibitory neurons whose function is to modulate the firing activities of the excitatory projection neurons.
Charles Edward Arber, Meng eLi, Meng eLi
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Molecular development and laminar distribution of GABAergic interneurons of the cerebral cortex [PDF]
GABAergic interneurons of the cerebral cortex represent one of the most diversified populations of cells of the Central Nervous System. It is well established that different subtypes of interneurons populate and integrate into the cortical layers, where
Lodato, Simona
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The Interneuron Class Struggle [PDF]
In this issue of Cell, Gouwens et al. establish the state of the art for defining inhibitory cell types in the mouse neocortex. By combining morphological, electrophysiological, and transcriptomic features to classify interneurons in the mouse visual cortex, this work provides a roadmap for understanding the diversity of cell types and their functional
Jacob M, Ratliff, Renata, Batista-Brito
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Mitochondrial dysfunction has been increasingly linked to neurodevelopmental disorders such as intellectual disability, childhood epilepsy, and autism spectrum disorder, conditions also associated with cortical GABAergic interneuron dysfunction. Although
Erika G. Lin-Hendel +4 more
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CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration [PDF]
SummaryCXCL12/CXCR4 signaling is critical for cortical interneuron migration and their final laminar distribution. No information is yet available on CXCR7, a newly defined CXCL12 receptor.
Gregory B. Potter +17 more
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Summary: Interneuron migration involves repetitive cycles of pausing and motion that include nucleokinesis and dynamic branching of the leading process.
Fanny Lepiemme +2 more
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Interneuron properties and PC gain modulation.
A) A network with a homogeneous FS interneuron population was developed to explore the role of interneuron synaptic properties upon PC gain. B) Histogram of FS-to-PC synaptic latencies before (purple, ‘FS’) and after (green, ‘NFS’) modification to ...
Steven Petrou (706920) +3 more
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Cortical control of chandelier cells in neural codes
Various cortical functions arise from the dynamic interplay of excitation and inhibition. GABAergic interneurons that mediate synaptic inhibition display significant diversity in cell morphology, electrophysiology, plasticity rule, and connectivity ...
Kanghoon Jung +2 more
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Comparison Between Supervised and Unsupervised Classifications of Neuronal Cell Types: A Case Study [PDF]
In the study of neural circuits, it becomes essential to discern the different neuronal cell types that build the circuit. Traditionally, neuronal cell types have been classified using qualitative descriptors.
Laura M. McGarry +11 more
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Identifying Protocadherin Gamma-dependent Signaling Pathways that Regulate Interneuron Survival
Developmental programmed cell death (PCD) is critical for establishing balanced ratios of excitatory and inhibitory neurons, but the underlying mechanisms remain poorly understood.
Qiao, Julia Yujia
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