Results 21 to 30 of about 31,667 (251)

Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo

Cell Reports, 2020
Summary: The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood.
Charlotte Arlt, Michael Häusser
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Interneurons Scratch an Itch [PDF]

Neuron, 2014
Itch is immensely frustrating. Most studies focus on the cause of itch. In this issue of Neuron, Kardon et al. (2014) find that itch can be modulated by inhibitory neurons that produce dynorphin, an endogenous agonist of κ-opioid receptors.
Pereira, Paula Juliana Seadi, Lerner, Ethan A.   +1 more
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Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes

Cell Reports, 2021
Summary: GABAergic interneurons migrate long distances through stereotyped migration programs toward specific laminar positions. During their migration, GABAergic interneurons are morphologically alike but then differentiate into a rich array of ...
Christelle Cadilhac, Isabelle Bachy, Antoine Forget, David J. Hodson, Céline Jahannault-Talignani, Andrew J. Furley, Olivier Ayrault, Patrice Mollard, Constantino Sotelo, Fabrice Ango   +9 more
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Local axonal morphology guides the topography of interneuron myelination in mouse and human neocortex

eLife, 2019
GABAergic fast-spiking parvalbumin-positive (PV) interneurons are frequently myelinated in the cerebral cortex. However, the factors governing the topography of cortical interneuron myelination remain incompletely understood.
Jeffrey Stedehouder, Demi Brizee, Johan A Slotman, Maria Pascual-Garcia, Megan L Leyrer, Bibi LJ Bouwen, Clemens MF Dirven, Zhenyu Gao, David M Berson, Adriaan B Houtsmuller, Steven A Kushner   +10 more
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Cortical interneurons from human pluripotent stem cells: prospects for neurological and psychiatric disease

Frontiers in Cellular Neuroscience, 2013
Cortical interneurons represent 20% of the cells in the cortex. These cells are local inhibitory neurons whose function is to modulate the firing activities of the excitatory projection neurons.
Charles Edward Arber, Meng eLi, Meng eLi
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Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

eLife, 2022
Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth factor 15 (FGF15), a motogen ...
Rachana Deven Somaiya, Katelyn Stebbins, Ellen C Gingrich, Hehuang Xie, John N Campbell, A Denise R Garcia, Michael A Fox   +6 more
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Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders

Cell Reports, 2016
Mitochondrial dysfunction has been increasingly linked to neurodevelopmental disorders such as intellectual disability, childhood epilepsy, and autism spectrum disorder, conditions also associated with cortical GABAergic interneuron dysfunction. Although
Erika G. Lin-Hendel, Meagan J. McManus, Douglas C. Wallace, Stewart A. Anderson, Jeffrey A. Golden   +4 more
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Time lapse recording of cortical interneuron migration in mouse organotypic brain slices and explants

STAR Protocols, 2021
Summary: Interneuron migration involves repetitive cycles of pausing and motion that include nucleokinesis and dynamic branching of the leading process.
Fanny Lepiemme, Carla G. Silva, Laurent Nguyen   +2 more
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Cortical control of chandelier cells in neural codes

Frontiers in Cellular Neuroscience, 2022
Various cortical functions arise from the dynamic interplay of excitation and inhibition. GABAergic interneurons that mediate synaptic inhibition display significant diversity in cell morphology, electrophysiology, plasticity rule, and connectivity ...
Kanghoon Jung, Youngjin Choi, Hyung-Bae Kwon   +2 more
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The Interneuron Class Struggle [PDF]

Cell, 2020
In this issue of Cell, Gouwens et al. establish the state of the art for defining inhibitory cell types in the mouse neocortex. By combining morphological, electrophysiological, and transcriptomic features to classify interneurons in the mouse visual cortex, this work provides a roadmap for understanding the diversity of cell types and their functional
Jacob M, Ratliff, Renata, Batista-Brito
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