Results 21 to 30 of about 40,471 (297)
Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia. [PDF]
Adv Sci (Weinh)FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Ni P +17 more
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Frontiers in Synaptic Neuroscience, 2022 General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous
Iris A. Speigel +2 more
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Interneuron development and dysfunction [PDF]
The FEBS Journal, 2021 Understanding excitation and inhibition balance in the brain begins with the tale of two basic types of neurons, glutamatergic projection neurons and GABAergic interneurons. The diversity of cortical interneurons is contributed by multiple origins in the ventral forebrain, various tangential migration routes, and complicated regulations of intrinsic ...
Jiaxin Yang, Xiong Yang, Ke Tang
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eLife, 2020 In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity.
Igor Gridchyn +3 more
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A Novel LHX6 Reporter Cell Line for Tracking Human iPSC-Derived Cortical Interneurons
Cells, 2022 GABAergic interneurons control the neural circuitry and network activity in the brain. The dysfunction of cortical interneurons, especially those derived from the medial ganglionic eminence, contributes to neurological disease states.
Maria Cruz-Santos +2 more
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Author Response: Letter to the Editor—Reconsidering Control Logic and Translational Interpretation in TNEA‐Based Modulation of Hippocampal Oscillations [PDF]
Advanced scienceAdvanced Science, EarlyView.
Guo Z, Wang D.
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Genetic impairment of folate metabolism regulates cortical interneurons and social behavior
Frontiers in Neuroscience, 2023 IntroductionThe implications of folate deficiency in neuropsychiatric disorders were demonstrated in numerous studies. Genetic deficiency in a key folate metabolism enzyme, MTHFR, is an example of the interaction between genetic and environmental risk ...
Noa Sadigurschi +5 more
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Modeling interneuron-specific (IS) interneurons in hippocampus [PDF]
BMC Neuroscience, 2014 The hippocampus and cortex have a large diversity in inhibitory interneuron types. These local interneurons exert inhibitory control over neuronal populations in the hippocampus [1]. Although much is known about how hippocampal inhibitory interneurons exert control over pyramidal cells and synchronize local network activity, less is known about how the
Guet-McCreight, Alexandre +3 more
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eLife, 2016 Interneurons are critical for proper neural network function and can activate Ca2+ signaling in astrocytes. However, the impact of the interneuron-astrocyte signaling into neuronal network operation remains unknown.
Gertrudis Perea +18 more
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eLife, 2021 Cortical interneurons establish inhibitory microcircuits throughout the neocortex and their dysfunction has been implicated in epilepsy and neuropsychiatric diseases.
Matthieu Genestine +14 more
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