Cellular signaling impacts upon GABAergic cortical interneuron development [PDF]
Frontiers in Neuroscience, 2023 The development and maturation of cortical GABAergic interneurons has been extensively studied, with much focus on nuclear regulation via transcription factors.
Emily Ling-Lin Pai +3 more
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Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico. [PDF]
PLoS Computational BiologyReduced cortical inhibition by parvalbumin-expressing (PV) interneurons in schizophrenia is thought to be associated with impaired processing in the prefrontal cortex and altered EEG signals such as oddball mismatch negativity (MMN).
Sana Rosanally +5 more
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Modifying PCDH19 levels affects cortical interneuron migration
Frontiers in Neuroscience, 2022 PCDH19 is a transmembrane protein and member of the protocadherin family. It is encoded by the X-chromosome and more than 200 mutations have been linked to the neurodevelopmental PCDH-clustering epilepsy (PCDH19-CE) syndrome.
Anna Pancho +20 more
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Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity
Cell ReportsSummary: Spinal neural circuits that execute movement are composed of cardinal classes of neurons that emerged from distinct progenitor lineages. Each cardinal class contains multiple neuronal subtypes characterized by distinct molecular, anatomical, and
Dylan Deska-Gauthier +8 more
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Cell Reports, 2019 Summary: Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the
Anirban Paul, Jeanne Paz, Jia Sheng Hu
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Heterotopic Transplantations Reveal Environmental Influences on Interneuron Diversity and Maturation
Cell Reports, 2017 During embryogenesis, neural progenitors in the ganglionic eminences give rise to diverse GABAergic interneuron subtypes that populate all forebrain regions.
Giulia Quattrocolo +2 more
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Interneuron progenitor transplantation to treat CNS dysfunction
Frontiers in Neural Circuits, 2016 Due to the inadequacy of endogenous repair mechanisms diseases of the nervous system remain a major challenge to scientists and clinicians. Stem cell based therapy is an exciting and viable strategy that has been shown to ameliorate or even reverse ...
Muhammad O Chohan +3 more
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Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. [PDF]
PLoS ONE, 2012 Although extensive research has demonstrated the importance of excitatory granule neurons in the dentate gyrus of the hippocampus in normal learning and memory and in the pathogenesis of amnesia in Alzheimer's disease (AD), the role of hilar GABAergic ...
Yaisa Andrews-Zwilling +13 more
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Deletion of Alg13 disrupts postnatal development and migration of GABAergic cortical interneurons [PDF]
Frontiers in NeurologyBackgroundAbnormal cortical neuron development is closely associated with various neurological disorders. Deletion of the Alg13 gene has been identified as strongly associated with epilepsy susceptibility and seizure severity in mice.
Haibo Liu +9 more
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In-silico EEG biomarkers of reduced inhibition in human cortical microcircuits in depression.
PLoS Computational Biology, 2023 Reduced cortical inhibition by somatostatin-expressing (SST) interneurons has been strongly associated with treatment-resistant depression. However, due to technical limitations it is impossible to establish experimentally in humans whether the effects ...
Frank Mazza +4 more
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