Results 11 to 20 of about 31,667 (251)

Interneuron development and dysfunction [PDF]

The FEBS Journal, 2021
Understanding excitation and inhibition balance in the brain begins with the tale of two basic types of neurons, glutamatergic projection neurons and GABAergic interneurons. The diversity of cortical interneurons is contributed by multiple origins in the ventral forebrain, various tangential migration routes, and complicated regulations of intrinsic ...
Jiaxin Yang, Xiong Yang, Ke Tang
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Genetic impairment of folate metabolism regulates cortical interneurons and social behavior

Frontiers in Neuroscience, 2023
IntroductionThe implications of folate deficiency in neuropsychiatric disorders were demonstrated in numerous studies. Genetic deficiency in a key folate metabolism enzyme, MTHFR, is an example of the interaction between genetic and environmental risk ...
Noa Sadigurschi, Gilad Schrift, Johannes Hirrlinger, Johannes Hirrlinger, Hava M. Golan, Hava M. Golan   +5 more
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Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

eLife, 2016
Interneurons are critical for proper neural network function and can activate Ca2+ signaling in astrocytes. However, the impact of the interneuron-astrocyte signaling into neuronal network operation remains unknown.
Gertrudis Perea, Ricardo Gómez, Sara Mederos, Ana Covelo, Jesús J Ballesteros, Laura Schlosser, Alicia Hernández-Vivanco, Mario Martín-Fernández, Ruth Quintana, Abdelrahman Rayan, Adolfo Díez, Marco Fuenzalida, Amit Agarwal, Dwight E Bergles, Bernhard Bettler, Denise Manahan-Vaughan, Eduardo D Martín, Frank Kirchhoff, Alfonso Araque   +18 more
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Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

eLife, 2021
Cortical interneurons establish inhibitory microcircuits throughout the neocortex and their dysfunction has been implicated in epilepsy and neuropsychiatric diseases.
Matthieu Genestine, Daisy Ambriz, Gregg W Crabtree, Patrick Dummer, Anna Molotkova, Michael Quintero, Angeliki Mela, Saptarshi Biswas, Huijuan Feng, Chaolin Zhang, Peter Canoll, Gunnar Hargus, Dritan Agalliu, Joseph A Gogos, Edmund Au   +14 more
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Cortical interneurons in autism

Nature Neuroscience, 2021
The mechanistic underpinnings of autism remain a subject of debate and controversy. Why do individuals with autism share an overlapping set of atypical behaviors and symptoms, despite having different genetic and environmental risk factors? A major challenge in developing new therapies for autism has been the inability to identify convergent neural ...
Anis Contractor, Iryna M. Ethell, Carlos Portera-Cailliau   +2 more
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Application of cluster analysis in morphological characteristics of neurons

浙江大学学报. 农业与生命科学版, 2011
Base on the data for three dimensional (3D) coordinate of 49 neurons, 16 morphological parameters were obtained by calculation. According to the factor analysis of the morphological parameters, three major characteristics, including dimension, degree of ...
ZHANG Jing, DENG Shi-huai, GUO Hang, SHEN Fei, GU Wei-gang, LI Yuan-wei   +5 more
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Modeling interneuron-specific (IS) interneurons in hippocampus [PDF]

BMC Neuroscience, 2014
The hippocampus and cortex have a large diversity in inhibitory interneuron types. These local interneurons exert inhibitory control over neuronal populations in the hippocampus [1]. Although much is known about how hippocampal inhibitory interneurons exert control over pyramidal cells and synchronize local network activity, less is known about how the
Guet-McCreight, Alexandre, Camiré, Olivier, Topolnik, Lisa, Skinner, Frances   +3 more
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Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain

Stem Cell Research, 2018
GABAergic interneuron dysfunction has been implicated in temporal lobe epilepsy (TLE), autism, and schizophrenia. Inhibitory interneuron progenitors transplanted into the hippocampus of rodents with TLE provide varying degrees of seizure suppression.
Nickesha C. Anderson, Meghan A. Van Zandt, Swechhya Shrestha, Daniel B. Lawrence, Jyoti Gupta, Christopher Y. Chen, Felicia A. Harrsch, Trinithas Boyi, Carolyn E. Dundes, Gloster Aaron, Janice R. Naegele, Laura Grabel   +11 more
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Modifying PCDH19 levels affects cortical interneuron migration

Frontiers in Neuroscience, 2022
PCDH19 is a transmembrane protein and member of the protocadherin family. It is encoded by the X-chromosome and more than 200 mutations have been linked to the neurodevelopmental PCDH-clustering epilepsy (PCDH19-CE) syndrome.
Anna Pancho, Manuela D. Mitsogiannis, Tania Aerts, Marco Dalla Vecchia, Marco Dalla Vecchia, Marco Dalla Vecchia, Lena K. Ebert, Lena K. Ebert, Lieve Geenen, Lieve Geenen, Lut Noterdaeme, Ria Vanlaer, Anne Stulens, Paco Hulpiau, Paco Hulpiau, Katrien Staes, Frans Van Roy, Peter Dedecker, Bernhard Schermer, Bernhard Schermer, Eve Seuntjens   +20 more
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Divisive Inhibition Prevails During Simultaneous Optogenetic Activation of All Interneuron Subtypes in Mouse Primary Visual Cortex

Frontiers in Neural Circuits, 2019
The mouse primary visual cortex (V1) has become an important brain area for exploring how neural circuits process information. Optogenetic tools have helped to outline the connectivity of a local V1 circuit comprising excitatory pyramidal neurons and ...
Tony G. J. Ingram, Jillian L. King, Nathan A. Crowder   +2 more
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