Results 51 to 60 of about 57,978 (299)

Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity

Cell Reports
Summary: Spinal neural circuits that execute movement are composed of cardinal classes of neurons that emerged from distinct progenitor lineages. Each cardinal class contains multiple neuronal subtypes characterized by distinct molecular, anatomical, and
Dylan Deska-Gauthier, Joanna Borowska-Fielding, Chris Jones, Han Zhang, Colin S. MacKay, Ramez Michail, Laura A. Bennett, Jay B. Bikoff, Ying Zhang   +8 more
doaj   +1 more source

Development of Cortical Interneurons [PDF]

Neuropsychopharmacology, 2014
Inhibitory local circuit neurons (LCNs), often called interneurons, have vital roles in the development and function of cortical networks. Their inhibitory influences regulate both the excitability of cortical projection neurons on the level of individual cells, and the synchronous activity of projection neuron ensembles that appear to be a neural ...
Jianhua, Chu, Stewart A, Anderson
openaire   +2 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons

eLife, 2016
Neocortical GABAergic interneuron migration and thalamo-cortical axon (TCA) pathfinding follow similar trajectories and timing, suggesting they may be interdependent.
Sabrina Zechel, Yasushi Nakagawa, Carlos F Ibáñez   +2 more
doaj   +1 more source

Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. [PDF]

PLoS ONE, 2012
Although extensive research has demonstrated the importance of excitatory granule neurons in the dentate gyrus of the hippocampus in normal learning and memory and in the pathogenesis of amnesia in Alzheimer's disease (AD), the role of hilar GABAergic ...
Yaisa Andrews-Zwilling, Anna K Gillespie, Alexxai V Kravitz, Alexandra B Nelson, Nino Devidze, Iris Lo, Seo Yeon Yoon, Nga Bien-Ly, Karen Ring, Daniel Zwilling, Gregory B Potter, John L R Rubenstein, Anatol C Kreitzer, Yadong Huang   +13 more
doaj   +1 more source

The spike train statistics for consonant and dissonant musical accords

, 2009
The simple system composed of three neural-like noisy elements is considered. Two of them (sensory neurons or sensors) are stimulated by noise and periodic signals with different ratio of frequencies, and the third one (interneuron) receives the output ...
A. de Cheveigné, Alexander A. Dubkov, Bernardo Spagnolo, C. F. Lo, C. J. Plack, C. W. Gardiner, D. Cox, H. C. Tuckwell, H. G. Schuster, H. L. F. Helmholtz, L. Glass, M. J. Tramo, W. Gerstner, Y. I. Fishman, Yuriy V. Ushakov   +14 more
core   +1 more source

Artifact‐Minimizing Ultrathin Transparent Electrodes Fabricated via iCVD for In Vivo Optogenetic Stimulation and Neural Signal Monitoring of Primary Visual Cortex

Advanced Functional Materials, EarlyView.
We present ultrathin flexible transparent electrodes through iCVD‐enabled molecular control of 10 nm gold films on poly(dimethylaminomethylstyrene). In vivo validation demonstrated photoelectric artifact reduction vs. opaque electrodes and preservation of natural neural dynamics.
Tae Jin Mun, Minju Kim, Chaesung Kim, Yunyoung Choi, In‐Yeop Baek, Younghak Cho, Gyeongyong Lee, Yerim Jang, Min‐Ho Nam, Wonryung Lee, Maesoon Im, Hyejeong Seong   +11 more
wiley   +1 more source

May We Have Your Attention: Analysis of a Selective Attention Task [PDF]

, 2004
In this paper we present a deeper analysis than has previously been carried out of a selective attention problem, and the evolution of continuous-time recurrent neural networks to solve it.
Beer, Randall D, Garcowski, Jacob R, Goldenberg, Eldan   +2 more
core  

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]

, 2013
Important modulatory roles have been attributed to presynaptic NMDA receptors (NMDARs) located on cerebellar interneuron terminals. Evidence supporting a presynaptic location includes an increase in the frequency of mini events following the application ...
Benton, DCH, Caldwell, M, Moss, GWJ, Robertson, AD, Smart, TG   +4 more
core   +1 more source