Results 71 to 80 of about 40,471 (297)

Table_2_The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming.XLSX

, 2019
Oligodendrocyte precursor cells (OPCs), also known as NG2 glia, arise from neural progenitor cells in the embryonic ganglionic eminences that also generate inhibitory neurons.
Chuntao Zhao (2498599), Daniel C. Factor (7160855), Akiko Nishiyama (349980), Vijender Singh (183359), Linda L. Boshans (7160852), Jia Liu (41593), Ion Mandoiu (663334), Paul J. Tesar (7160861), Q. Richard Lu (7160858), Patrizia Casaccia (225204)   +9 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Inhibiting Alzheimer’s disease by restoring Parvalbumin interneuron activity [PDF]

, 2021
The main aim of my project was to explore the role of hippocampal PV interneurons in AD-associated memory deficits and network imbalance. In Chapter 2, we uncovered that PV interneurons are hyperexcitable at an early disease stage in APP/PS1 mice.
Hijazi, Sara
core   +1 more source

Table_3_The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming.XLSX

, 2019
Oligodendrocyte precursor cells (OPCs), also known as NG2 glia, arise from neural progenitor cells in the embryonic ganglionic eminences that also generate inhibitory neurons.
Chuntao Zhao (2498599), Daniel C. Factor (7160855), Akiko Nishiyama (349980), Vijender Singh (183359), Linda L. Boshans (7160852), Jia Liu (41593), Ion Mandoiu (663334), Paul J. Tesar (7160861), Q. Richard Lu (7160858), Patrizia Casaccia (225204)   +9 more
core   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons

eLife, 2016
Neocortical GABAergic interneuron migration and thalamo-cortical axon (TCA) pathfinding follow similar trajectories and timing, suggesting they may be interdependent.
Sabrina Zechel, Yasushi Nakagawa, Carlos F Ibáñez   +2 more
doaj   +1 more source

Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Nature Communications, 2020
Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporating ...
Matt Udakis, Victor Pedrosa, Sophie E. L. Chamberlain, Claudia Clopath, Jack R. Mellor   +4 more
doaj   +1 more source

Development of Cortical Interneurons [PDF]

Neuropsychopharmacology, 2014
Inhibitory local circuit neurons (LCNs), often called interneurons, have vital roles in the development and function of cortical networks. Their inhibitory influences regulate both the excitability of cortical projection neurons on the level of individual cells, and the synchronous activity of projection neuron ensembles that appear to be a neural ...
Jianhua, Chu, Stewart A, Anderson
openaire   +2 more sources

Interneuron Heavy Metal Staining.

, 2016
A. Caudal lumbar spinal cord showing AMGHM-stained interneurons (INT) either peripheral to (B, D) or within (C) groups of unstained α-motoneurons (α-MN, within dashed outlines; lateral group right, medial group left) within the grey matter of the ...
Roger Pamphlett (435149), Stephen Kum Jew (3111579)   +1 more
core   +1 more source

Innovations present in the primate interneuron repertoire

, 2021
Primates and rodents, which descended from a common ancestor around 90 million years ago , exhibit profound differences in behaviour and cognitive capacity; the cellular basis for these differences is unknown. Here we use single-nucleus RNA sequencing to
Wu, Carolyn, Walsh, Christopher A., Schuman, Benjamin, Bien, Elizabeth, Florio, Marta, Fishell, Gord, Goldman, Melissa, C. H. del Rosario, Ricardo, Berretta, Sabina, Zhang, Qiangge, Dimidschstein, Jordane, Wysoker, Alec, Zaniewski, Heather, Kulp, David, Smith, Richard, Lin, Jessica D., Krienen, Fenna M., Mullally, Christopher D., Levandowski, Kirsten, Burns, Monika, Lutservitz, Alyssa, Nemesh, James, Fernandez-Otero, Marian, Tkachev, Victor, Feng, Guoping, Saunders, Arpiar, McCarroll, Steven A., Machold, Robert, Rudy, Bernardo, S. Kean, Leslie, Reed, Nora, Bortolin, Laura   +31 more
core   +1 more source