Results 91 to 100 of about 40,471 (297)

Interneuron Types as Attractors and Controllers

, 2019
Cortical interneurons display striking differences in shape, physiology, and other attributes, challenging us to appropriately classify them. We previously suggested that interneuron types should be defined by their role in cortical processing.
Kepecs, A., Fishell, G.
core   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Postnatal Migration of Cerebellar Interneurons [PDF]

Brain Sciences, 2017
Due to its continuing development after birth, the cerebellum represents a unique model for studying the postnatal orchestration of interneuron migration. The combination of fluorescent labeling and ex/in vivo imaging revealed a cellular highway network within cerebellar cortical layers (the external granular layer, the molecular layer, the Purkinje ...
Galas, Ludovic, Benard, Magalie, Lebon, Alexis, Komuro, Yutaro, Schapman, Damien, Vaudry, Hubert, Vaudry, David, Komuro, Hitoshi   +7 more
openaire   +5 more sources

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Developmental and activity-dependent plasticity of filiform hair receptors in the locust

Frontiers in Physiology, 2013
A group of wind sensitive filiform hair receptors on the locust thorax and head makes contact onto a pair of identified interneuron, A4I1. The hair receptors’ central nervous projections exhibit pronounced structural dynamics during nymphal development ...
Hans-Joachim ePflüger, Harald eWolf
doaj   +1 more source

Cortical somatostatin interneuron subtypes form cell-type-specific circuits

, 2023
The cardinal classes are a useful simplification of cortical interneuron diversity, but such broad subgroupings gloss over the molecular, morphological, and circuit specificity of interneuron subtypes, most notably among the somatostatin interneuron ...
Irving Barrera, Choi, Da Hae,, Barrera, Irving,, Kullander, Klas,, Evan Macosko, Rudy, Bernardo,, Fei Chen, Dwivedi, Deepanjali,, Da Hae Choi, Alvar Prönneke, Sevier, Elaine,, Sherer, Mia,, Hairston, Ariel,, Ariel Hairston, Mia Sherer, Chen, Fei,, Elaine Sevier, Giuseppe-Antonio Saldi, Mackenzie Lenahan, Saldi, Giuseppe-Antonio,, Stafford, David A.,, Giovanni Marrero, Macosko, Evan,, Shuhan Huang, Yanjie Qiu, Vipin Kumar, Fishell, Gord,, Marrero, Giovanni,, Deepanjali Dwivedi, David A. Stafford, Qiu, Yanjie,, Yu, Sabrina,, Daniella Rizzo, Sabrina Yu, Pronneke, Alvar,, Ashwini Shinde, Wu, Sherry Jingjing,, Sherry Jingjing Wu, Bernardo Rudy, Xu, Qing,, Klas Kullander, Lenahan, Mackenzie,, Kumar, Vipin,, Gord Fishell, Qing Xu, Abbott, Lydia,, Lydia Abbott, Shinde, Ashwini,, Rizzo, Daniella,, Huang, Shuhan,   +49 more
core   +1 more source

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

The Hunchback transcription factor determines interneuron molecular identity, morphology, and presynapse targeting in the Drosophila NB5-2 lineage.

PLoS Biology
Interneuron diversity within the central nervous system (CNS) is essential for proper circuit assembly. Functional interneurons must integrate multiple features, including combinatorial transcription factor (TF) expression, axon/dendrite morphology, and ...
Heather Q Pollington, Chris Q Doe
doaj   +1 more source