Results 41 to 50 of about 144,668 (268)
Frontiers in Molecular Neuroscience, 2018 Medium spiny neurons (MSNs) of the dorsal striatum represent the first relay of cortico–striato–thalamic loop, responsible for the initiation of voluntary movements and motor learning.
Svetlana M. Molchanova +10 more
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Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez +10 more
wiley +1 more source
Hydrophobic gating in BK channels
Nature Communications, 2018 BK channels are regulated by membrane voltage and intracellular Ca2+ but the structural features that block the ion flow in the closed state remain unknown.
Zhiguang Jia +4 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Subtotal hippocampal resection can leave residual hippocampal tissue, yet the immediate postoperative electrophysiologic evolution of such remnants is unknown. We describe a patient with drug‐resistant temporal lobe epilepsy in whom a hippocampal remnant was continuously monitored using a responsive neurostimulator (RNS) following subtotal ...
Patrick Hartnett +5 more
wiley +1 more source
Structural basis for membrane microdomain formation by a human Stomatin complex
Nature CommunicationsBiological membranes are not just passive barriers—they actively sense and respond to mechanical forces, in part through specialized proteins embedded within them.
Jack Stoner, Shufang Li, Ziao Fu
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Do emotions have a positive effect on the decision-making process? neuroscience-based economics approach [PDF]
New Applied Studies in Management, Economics & Accounting, 2019 The combination of research methods conducted in psychology, economics, and neuroscience play an important role in deeper understanding of the causes and effects of emotional processes in decision making.
Amin Salem Ghahfarrokhi +3 more
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Dentate Granule Cells Recruited in the Home Environment Display Distinctive Properties
Frontiers in Cellular Neuroscience, 2021 The dentate granule cells (DGCs) play a crucial role in learning and memory. Many studies have described the role and physiological properties of these sparsely active neurons using different behavioral contexts.
Claire Pléau +8 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma +16 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 In animal models of Parkinson’s disease (PD), principal striatal spiny projection neurons (SPNs) lose axospinous synapses. However, there has been a disagreement about whether this loss is restricted to a specific type of SPN or not, as some studies have
Steven M. Graves, D. James Surmeier
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