Cell Reports, 2020 Summary: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging.
Patrick Lüningschrör +17 more
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Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment
Cells, 2020 By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and ...
Ana Rita Costa, Monica M. Sousa
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Alterations in the axon initial segment plasticity is involved in early pathogenesis in Alzheimer's disease [PDF]
MedCommAlzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by the early presence of amyloid‐β (Aβ) and hyperphosphorylated tau.
Yu Li +11 more
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Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment [PDF]
BiomoleculesThe axon initial segment (AIS) is a specialized subcellular domain that plays an essential role in action potential initiation and the diffusion barrier.
Xiaowei Zhu +4 more
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Actin polymerization and longitudinal actin fibers in axon initial segment plasticity [PDF]
Frontiers in Molecular NeuroscienceThe location of the axon initial segment (AIS) at the junction between the soma and axon of neurons makes it instrumental in maintaining neural polarity and as the site for action potential generation. The AIS is also capable of large-scale relocation in
David Micinski +3 more
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Axon initial segment structure and function in health and disease [PDF]
Physiological ReviewsKevin Bender, Paul Jenkins
exaly +2 more sources
Axon initial segment geometry in relation to motoneuron excitability.
PLoS ONE, 2021 The axon initial segment (AIS) responsible for action potential initiation is a dynamic structure that varies and changes together with neuronal excitability.
Travis M Rotterman +5 more
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THE AXON HILLOCK AND THE INITIAL SEGMENT [PDF]
The Journal of Cell Biology, 1968 Axon hillocks and initial segments have been recognized and studied in electron micrographs of a wide variety of neurons. In all multipolar neurons the fine structure of the initial segment has the same pattern, whether or not the axon is ensheathed in myelin. The internal structure of the initial segment is characterized by three special features: (a)
S L, Palay +3 more
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Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development. [PDF]
PLoS ONE, 2010 The development of morphological neuronal polarity starts by the formation and elongation of an axon. At the same time the axon initial segment (AIS) is generated and creates a diffusion barrier which differentiate axon and somatodendritic compartment ...
Mónica Tapia +2 more
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Electrogenic Tuning of the Axon Initial Segment [PDF]
The Neuroscientist, 2009 Action potentials (APs) provide the primary means of rapid information transfer in the nervous system. Where exactly these signals are initiated in neurons has been a basic question in neurobiology and the subject of extensive study. Converging lines of evidence indicate that APs are initiated in a discrete and highly specialized portion of the axon ...
Brian D, Clark +2 more
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