Results 11 to 20 of about 29,685 (270)
Plasticity at the axon initial segment [PDF]
Communicative & Integrative Biology, 2010 Experience dependent alterations in neural activity are mediated by diverse forms of plasticity, which are conventionally thought to occur at either synaptic terminals and/or postsynaptic membrane, such as dendrites and cell soma.
Hiroshi Kuba
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P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development [PDF]
Frontiers in Cellular Neuroscience, 2019 Morphological and functional polarization of neurons depends on the generation and maintenance of the axon initial segment (AIS). This axonal domain maintains axonal properties but is also the place where the action potential (AP) is generated. All these
Wei Zhang +5 more
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The Axon Initial Segment: An Updated Viewpoint [PDF]
The Journal of Neuroscience, 2018 International audienceAt the base of axons sits a unique compartment called the axon initial segment (AIS). The AIS generates and shapes the action potential before it is propagated along the axon.
Leterrier, Christophe +1 more
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Signal Processing in the Axon Initial Segment [PDF]
Neuron, 2012 The axon initial segment (AIS) is a specialized membrane region in the axon of neurons where action potentials are initiated. Crucial to the function of the AIS is the presence of specific voltage-gated channels clustered at high densities, giving the ...
Stuart, G.J. +4 more
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Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development. [PDF]
PLoS ONE, 2010 The development of morphological neuronal polarity starts by the formation and elongation of an axon. At the same time the axon initial segment (AIS) is generated and creates a diffusion barrier which differentiate axon and somatodendritic compartment ...
Mónica Tapia +2 more
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Imaging of the axon initial segment
Current Protocols in Neuroscience, 2019 The axon initial segment (AIS) is the first 20- to 60-?m segment of the axon proximal to the soma of a neuron. This highly specialized subcellular domain is the initiation site of the action potential and contains a high concentration of voltage-gated ...
Gonzalo Botello‐Lins +9 more
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Building and maintaining the axon initial segment [PDF]
Current Opinion in Neurobiology, 2010 The axon initial segment is a unique neuronal subregion involved in the initiation of action potentials and in the control of axonal identity. Recent work has helped our understanding of how this specialised structure develops, not least in identifying ...
Grubb, Matthew S.; id_orcid +1 more
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Axon initial segment structure and function in health and disease [PDF]
Physiological ReviewsAt the simplest level, neurons are structured to integrate synaptic input and perform computational transforms on that input, converting it into an action potential (AP) code.
Paul M Jenkins, Kevin J Bender
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Inhibitory Synapse Formation at the Axon Initial Segment [PDF]
Frontiers in Molecular Neuroscience, 2019 The axon initial segment (AIS) is the site of action potential (AP) initiation in most neurons and is thus a critical site in the regulation of neuronal excitability.
Anna J. Nathanson +4 more
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Structural and functional plasticity at the axon initial segment [PDF]
Frontiers in Cellular Neuroscience, 2016 The axon initial segment (AIS) is positioned between the axonal and somato-dendritic compartments and plays a pivotal role in triggering action potentials and determining neuronal output.
Rei Yamada, Hiroshi Kuba
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