Results 41 to 50 of about 29,685 (270)

Structure and function of axo-axonic inhibition

eLife, 2021
Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological, molecular, and connectivity signatures. While considerable work has measured the average connectivity of several interneuron classes, there remains a fundamental lack of
Casey M Schneider-Mizell, Agnes L Bodor, Forrest Collman, Derrick Brittain, Adam Bleckert, Sven Dorkenwald, Nicholas L Turner, Thomas Macrina, Kisuk Lee, Ran Lu, Jingpeng Wu, Jun Zhuang, Anirban Nandi, Brian Hu, JoAnn Buchanan, Marc M Takeno, Russel Torres, Gayathri Mahalingam, Daniel J Bumbarger, Yang Li, Thomas Chartrand, Nico Kemnitz, William M Silversmith, Dodam Ih, Jonathan Zung, Aleksandar Zlateski, Ignacio Tartavull, Sergiy Popovych, William Wong, Manuel Castro, Chris S Jordan, Emmanouil Froudarakis, Lynne Becker, Shelby Suckow, Jacob Reimer, Andreas S Tolias, Costas A Anastassiou, H Sebastian Seung, R Clay Reid, Nuno Maçarico da Costa   +39 more
doaj   +1 more source

FGF14 localization and organization of the axon initial segment [PDF]

Molecular and Cellular Neuroscience, 2013
The axon initial segment (AIS) is highly enriched in the structural proteins ankyrin G and βIV-spectrin, the pore-forming (α) subunits of voltage-gated sodium (Nav) channels, and functional Nav channels, and is critical for the initiation of action potentials.
Maolei, Xiao, Marie K, Bosch, Jeanne M, Nerbonne, David M, Ornitz   +3 more
openaire   +2 more sources

Calcium channels and GABAA receptors shape action potential generation at the axon initial segment [PDF]

, 2023
The axon initial segment is a specialized region of most neurons where action potentials are initiated. The function of this compartment is derived from its dense collection of ion channels and scaffolding proteins, ranging from voltage-gated sodium ...
Lipkin, Anna Marie
core  

Sodium channel endocytosis drives axon initial segment plasticity. [PDF]

Sci Adv, 2023
Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity.
Fréal A, Jamann N, Ten Bos J, Jansen J, Petersen N, Ligthart T, Hoogenraad CC, Kole MHP.   +7 more
europepmc   +2 more sources

Axon initial segments: structure, function, and disease [PDF]

Annals of the New York Academy of Sciences, 2018
AbstractThe axon initial segment (AIS) is located at the proximal axon and is the site of action potential initiation. This reflects the high density of ion channels found at the AIS. Adaptive changes to the location and length of the AIS can fine‐tune the excitability of neurons and modulate plasticity in response to activity.
Claire Yu‐Mei Huang, Matthew N. Rasband   +1 more
openaire   +2 more sources

Endocytosis in the axon initial segment maintains neuronal polarity. [PDF]

Nature, 2022
Abstract Neurons are highly polarized cells that face the fundamental challenge of compartmentalizing a vast and diverse repertoire of proteins in order to function properly1. The axon initial segment (AIS) is a specialized domain that separates a neuron’s morphologically, biochemically and functionally distinct axon and dendrite ...
Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, Südhof TC, Malenka R, Wernig M, Özkan E, Perrais D, Shen K.   +12 more
europepmc   +3 more sources

Axon initial segment dysfunction in epilepsy [PDF]

The Journal of Physiology, 2010
The axon initial segment (AIS) contains the site of action potential initiation and plays a major role in neuronal excitability. AIS function relies on high concentrations of different ion channels and complex regulatory mechanisms that orchestrate molecular microarchitecture.
Verena C. Wimmer, Christopher A. Reid, Eva Y.-W. So, Samuel F. Berkovic, Steven Petrou   +4 more
openaire   +3 more sources

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons

Cell Reports, 2020
Summary: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging.
Patrick Lüningschrör, Georg Werner, Stijn Stroobants, Soichiro Kakuta, Benjamin Dombert, Daniela Sinske, Renate Wanner, Renate Lüllmann-Rauch, Benedikt Wefers, Wolfgang Wurst, Rudi D’Hooge, Yasuo Uchiyama, Michael Sendtner, Christian Haass, Paul Saftig, Bernd Knöll, Anja Capell, Markus Damme   +17 more
doaj   +1 more source

IκBα is not required for axon initial segment assembly [PDF]

Molecular and Cellular Neuroscience, 2012
The inhibitor of NF-κB alpha (IκBα) protein is an important regulator of the transcription factor NF-κB. In neurons, IκBα has been shown to play a role in neurite outgrowth and cell survival. Recently, a phosphorylated form of IκBα (pIκBα Ser32/36) was reported to be highly enriched at the axon initial segment (AIS) and was proposed to function ...
Shelly A, Buffington, Jürgen M, Sobotzik, Christian, Schultz, Matthew N, Rasband   +3 more
openaire   +2 more sources

Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function

Alzheimer’s Research & Therapy, 2017
Background Serotonin receptor 5-HT6 is involved in cognition and Alzheimer’s disease (AD) development. However, the mechanism of 5-HT6 in AD pathology is not clear.
Lili Hu, Bingjie Wang, Yan Zhang
doaj   +1 more source