Results 41 to 50 of about 28,691 (244)
Cell Reports, 2019 Summary: The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear.
Xingxiu Pan +9 more
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eLife, 2020 Ion channel complexes promote action potential initiation at the mammalian axon initial segment (AIS), and modulation of AIS size by recruitment or loss of proteins can influence neuron excitability.
Aniket Ghosh +3 more
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Consciousness and spintronic coherence in microtubules
Communicative & Integrative BiologyMicrotubules are nanoscale spintronic oscillators with memristive properties. Spintronic and memristive effects, together with some unique conditions found in the axon initial segment (AIS), allow quantum coherence to emerge spontaneously in a population
Majid Beshkar
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Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.
PLoS Computational Biology, 2020 The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. Although recent works have highlighted the complexity of their dendritic organization and synaptic inputs, the mechanisms through which these neurons integrate complex
Stefano Masoli +3 more
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Spikelets in Pyramidal Neurons: Action Potentials Initiated in the Axon Initial Segment That Do Not Activate the Soma. [PDF]
PLoS Computational Biology, 2017 Spikelets are small spike-like depolarizations that can be measured in somatic intracellular recordings. Their origin in pyramidal neurons remains controversial.
Martina Michalikova +2 more
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EBioMedicine, 2021 Background: tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial ...
Sana Amanat +11 more
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Segmentation of Membrane Protein Motion in the Axon Initial Segment [PDF]
Biophysical Journal, 2016 The axon initial segment (AIS) is a structure rich in specific cytoskeletal molecules that play important roles in the concentration of ion-channels that are required for action-potential generation. The establishment of a postulated diffusion barrier to the lateral exchange of membrane molecules in the AIS correlates with the enrichment of specific ...
Winterflood, Christian M. +4 more
openaire +2 more sources
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
Frontiers in Neural Circuits, 2022 In the mammalian brain, auditory brainstem nuclei are arranged topographically according to acoustic frequency responsiveness. During postnatal development, the axon initial segment (AIS) of principal neurons undergoes structural refinement depending on ...
Mackenna Wollet, Jun Hee Kim
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source