Results 51 to 60 of about 29,685 (270)

Glucose Increases the Length and Spacing of the Lattice Structure of the Axon Initial Segment

, 2022
The dataset contains SIM and Patch data from "Glucose Increases the Length and Spacing of the Lattice Structure of the Axon Initial Segment" (Under ...
yiming wang (12169112)
core   +1 more source

MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon

Cell Reports, 2019
Summary: The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear.
Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Peter Jan Hooikaas, Sybren Portegies, Lena Will, Maud Martin, Anna Akhmanova, Martin Harterink, Casper C. Hoogenraad   +9 more
doaj   +1 more source

Axon Initial Segment Stability in Multiple Sclerosis

, 2015
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by inflammation and demyelination. In addition to these hallmark features, MS also presents with axonal pathology, which is likely responsible for the signs and ...
Thummala, Suneel K
core   +1 more source

Axon Initial Segment

, 2018
International audienceThe axon initial segment (AIS) is a specialised region of the axon where the action potential is initiated following integration of excitatory and inhibitory inputs.
Debanne, Dominique, Garrido, Juan, José, Dominique Debanne, Juan José Garrido   +3 more
core   +1 more source

Consciousness and spintronic coherence in microtubules

Communicative & Integrative Biology
Microtubules are nanoscale spintronic oscillators with memristive properties. Spintronic and memristive effects, together with some unique conditions found in the axon initial segment (AIS), allow quantum coherence to emerge spontaneously in a population
Majid Beshkar
doaj   +1 more source

Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.

PLoS Computational Biology, 2020
The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. Although recent works have highlighted the complexity of their dendritic organization and synaptic inputs, the mechanisms through which these neurons integrate complex
Stefano Masoli, Alessandra Ottaviani, Stefano Casali, Egidio D'Angelo   +3 more
doaj   +1 more source

Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study

EBioMedicine, 2021
Background: tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial ...
Sana Amanat, Alvaro Gallego-Martinez, Joseph Sollini, Patricia Perez-Carpena, Juan M. Espinosa-Sanchez, Ismael Aran, Andres Soto-Varela, Angel Batuecas‐Caletrio, Barbara Canlon, Patrick May, Christopher R. Cederroth, Jose A. Lopez-Escamez   +11 more
doaj   +1 more source

Segmentation of Membrane Protein Motion in the Axon Initial Segment [PDF]

Biophysical Journal, 2016
The axon initial segment (AIS) is a structure rich in specific cytoskeletal molecules that play important roles in the concentration of ion-channels that are required for action-potential generation. The establishment of a postulated diffusion barrier to the lateral exchange of membrane molecules in the AIS correlates with the enrichment of specific ...
Winterflood, Christian M., Albrecht, David, de Wit, Gabrielle, Kukura, Philipp, Ewers, Helge   +4 more
openaire   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Brain-Derived Neurotrophic Factor Is Involved in Activity-Dependent Tonotopic Refinement of MNTB Neurons

Frontiers in Neural Circuits, 2022
In the mammalian brain, auditory brainstem nuclei are arranged topographically according to acoustic frequency responsiveness. During postnatal development, the axon initial segment (AIS) of principal neurons undergoes structural refinement depending on ...
Mackenna Wollet, Jun Hee Kim
doaj   +1 more source